Exosomal microRNA remodels the tumor microenvironment

• Published in: PeerJ (San Francisco, CA) Vol. 5; p. e4196
• Main Authors: Jiang, Xiaoli, Hu, Song, Liu, Qiang, Qian, Caiyun, Liu, Zhuoqi, Luo, Daya
• Format: Journal Article
• Language: English
• Published: United States PeerJ. Ltd 22.12.2017; PeerJ, Inc; PeerJ Inc
• Subjects: Adipocytes; Apoptosis; Biochemistry; Breast cancer; Cancer; Cancer genetics; Cancer metastasis; Cancer research; Cell growth; Development and progression; Drug resistance; Endogenous; Esophagus; Exogenous; Exosome; Fibroblasts; Genetic aspects; Metastases; Metastasis; MicroRNA; MicroRNAs; Milk; miRNA; Oncology; Proteins; Stem cells; Stromal cells; Therapeutic applications; Tumor cells; Tumor microenvironment; Exogenous; microRNA; Endogenous; Tumor microenvironment; Exosome

Tumor occurrence, progression and metastasis depend on the crosstalk between tumor cells and stromal cells and on extrinsic factors outside the tumor microenvironment. Exosomal microRNA (miRNA) not only is involved in communications within the tumor microenvironment but also mediates communications...