Human growth hormone receptor (GHR) expression in obesity: I. GHR mRNA expression in omental and subcutaneous adipose tissues of obese women
Objectives: Growth hormone (GH)-deficient individuals display increased adiposity that can be effectively reduced by GH therapy because of GH's lipolytic effects. However, similar GH treatments of individuals with idiopathic obesity (not associated with an endocrinopathy/syndrome) have had litt...
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| Published in | International Journal of Obesity Vol. 35; no. 12; pp. 1511 - 1519 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group
01.12.2011
Nature Publishing Group UK |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0307-0565 1476-5497 1476-5497 |
| DOI | 10.1038/ijo.2011.23 |
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| Abstract | Objectives: Growth hormone (GH)-deficient individuals display increased adiposity that can be effectively reduced by GH therapy because of GH's lipolytic effects. However, similar GH treatments of individuals with idiopathic obesity (not associated with an endocrinopathy/syndrome) have had little success. We hypothesized that this form of obesity may be associated with GH resistance at the level of the adipocyte because of reduced GH receptor (GHR) expression. Subjects and methods: We studied GHR expression in omental and subcutaneous fat tissues from a cohort of 55 women ranging from lean to obese by various adiposity parameters. mRNA levels of total GHR and the dominant-negative truncated GHR1−279 (trGHR) form were assayed by quantitative reverse transcriptase-PCR. Associations between adiposity measures and GHR levels as well as trGHR/GHR ratios were analyzed. Results: Total GHR mRNA expression was 2–3-fold lower in omental as well as subcutaneous adipose tissues of obese compared with lean women (P0.05–0.001). Lean individuals expressed higher GHR mRNA levels in omental fat compared with subcutaneous (P0.01); in obese women, this depot-specific difference was lost. Omental and subcutaneous adipose GHR mRNA levels displayed significant negative correlations with a spectrum of indicators of obesity while, in subcutaneous fat, there was a significantly higher trGHR/GHR ratio with increasing adiposity (P0.05). Conclusion: These results support our hypothesis that, with obesity, there is lower GHR expression in the adipocyte, and suggest one possible explanation why GH supplementation is not an effective treatment for individuals with idiopathic obesity. |
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| AbstractList | Growth hormone (GH)-deficient individuals display increased adiposity that can be effectively reduced by GH therapy because of GH's lipolytic effects. However, similar GH treatments of individuals with idiopathic obesity (not associated with an endocrinopathy/syndrome) have had little success. We hypothesized that this form of obesity may be associated with GH resistance at the level of the adipocyte because of reduced GH receptor (GHR) expression.OBJECTIVESGrowth hormone (GH)-deficient individuals display increased adiposity that can be effectively reduced by GH therapy because of GH's lipolytic effects. However, similar GH treatments of individuals with idiopathic obesity (not associated with an endocrinopathy/syndrome) have had little success. We hypothesized that this form of obesity may be associated with GH resistance at the level of the adipocyte because of reduced GH receptor (GHR) expression.We studied GHR expression in omental and subcutaneous fat tissues from a cohort of 55 women ranging from lean to obese by various adiposity parameters. mRNA levels of total GHR and the dominant-negative truncated GHR(1-279) (trGHR) form were assayed by quantitative reverse transcriptase-PCR. Associations between adiposity measures and GHR levels as well as trGHR/GHR ratios were analyzed.SUBJECTS AND METHODSWe studied GHR expression in omental and subcutaneous fat tissues from a cohort of 55 women ranging from lean to obese by various adiposity parameters. mRNA levels of total GHR and the dominant-negative truncated GHR(1-279) (trGHR) form were assayed by quantitative reverse transcriptase-PCR. Associations between adiposity measures and GHR levels as well as trGHR/GHR ratios were analyzed.Total GHR mRNA expression was 2-3-fold lower in omental as well as subcutaneous adipose tissues of obese compared with lean women (P ≤ 0.05-0.001). Lean individuals expressed higher GHR mRNA levels in omental fat compared with subcutaneous (P ≤ 0.01); in obese women, this depot-specific difference was lost. Omental and subcutaneous adipose GHR mRNA levels displayed significant negative correlations with a spectrum of indicators of obesity while, in subcutaneous fat, there was a significantly higher trGHR/GHR ratio with increasing adiposity (P ≤ 0.05).RESULTSTotal GHR mRNA expression was 2-3-fold lower in omental as well as subcutaneous adipose tissues of obese compared with lean women (P ≤ 0.05-0.001). Lean individuals expressed higher GHR mRNA levels in omental fat compared with subcutaneous (P ≤ 0.01); in obese women, this depot-specific difference was lost. Omental and subcutaneous adipose GHR mRNA levels displayed significant negative correlations with a spectrum of indicators of obesity while, in subcutaneous fat, there was a significantly higher trGHR/GHR ratio with increasing adiposity (P ≤ 0.05).These results support our hypothesis that, with obesity, there is lower GHR expression in the adipocyte, and suggest one possible explanation why GH supplementation is not an effective treatment for individuals with idiopathic obesity.CONCLUSIONThese results support our hypothesis that, with obesity, there is lower GHR expression in the adipocyte, and suggest one possible explanation why GH supplementation is not an effective treatment for individuals with idiopathic obesity. Objectives: Growth hormone (GH)-deficient individuals display increased adiposity that can be effectively reduced by GH therapy because of GH's lipolytic effects. However, similar GH treatments of individuals with idiopathic obesity (not associated with an endocrinopathy/syndrome) have had little success. We hypothesized that this form of obesity may be associated with GH resistance at the level of the adipocyte because of reduced GH receptor (GHR) expression. Subjects and methods: We studied GHR expression in omental and subcutaneous fat tissues from a cohort of 55 women ranging from lean to obese by various adiposity parameters. mRNA levels of total GHR and the dominant-negative truncated GHR 1−279 (trGHR) form were assayed by quantitative reverse transcriptase-PCR. Associations between adiposity measures and GHR levels as well as trGHR/GHR ratios were analyzed. Results: Total GHR mRNA expression was 2–3-fold lower in omental as well as subcutaneous adipose tissues of obese compared with lean women ( P ⩽0.05–0.001). Lean individuals expressed higher GHR mRNA levels in omental fat compared with subcutaneous ( P ⩽0.01); in obese women, this depot-specific difference was lost. Omental and subcutaneous adipose GHR mRNA levels displayed significant negative correlations with a spectrum of indicators of obesity while, in subcutaneous fat, there was a significantly higher trGHR/GHR ratio with increasing adiposity ( P ⩽0.05). Conclusion: These results support our hypothesis that, with obesity, there is lower GHR expression in the adipocyte, and suggest one possible explanation why GH supplementation is not an effective treatment for individuals with idiopathic obesity. Objectives: Growth hormone (GH)-deficient individuals display increased adiposity that can be effectively reduced by GH therapy because of GH's lipolytic effects. However, similar GH treatments of individuals with idiopathic obesity (not associated with an endocrinopathy/syndrome) have had little success. We hypothesized that this form of obesity may be associated with GH resistance at the level of the adipocyte because of reduced GH receptor (GHR) expression. Subjects and methods: We studied GHR expression in omental and subcutaneous fat tissues from a cohort of 55 women ranging from lean to obese by various adiposity parameters. mRNA levels of total GHR and the dominant-negative truncated [GHR.sub.1-279] (trGHR) form were assayed by quantitative reverse transcriptase-PCR. Associations between adiposity measures and GHR levels as well as trGHR/GHR ratios were analyzed. Results: Total GHR mRNA expression was 2-3-fold lower in omental as well as subcutaneous adipose tissues of obese compared with lean women (P ≤ 0.05-0.001). Lean individuals expressed higher GHR mRNA levels in omental fat compared with subcutaneous (P ≤ 0.01); in obese women, this depot-specific difference was lost. Omental and subcutaneous adipose GHR mRNA levels displayed significant negative correlations with a spectrum of indicators of obesity while, in subcutaneous fat, there was a significantly higher trGHR/GHR ratio with increasing adiposity (P ≤ 0.05). Conclusion: These results support our hypothesis that, with obesity, there is lower GHR expression in the adipocyte, and suggest one possible explanation why GH supplementation is not an effective treatment for individuals with idiopathic obesity. International Journal of Obesity (2011) 35, 1511 -1519; doi: 10.1038/ijo.2011.23; published online 8 March 2011 Keywords: growth hormone receptor; omental fat; subcutaneous fat; human female; GH resistance Objectives: Growth hormone (GH)-deficient individuals display increased adiposity that can be effectively reduced by GH therapy because of GH's lipolytic effects. However, similar GH treatments of individuals with idiopathic obesity (not associated with an endocrinopathy/syndrome) have had little success. We hypothesized that this form of obesity may be associated with GH resistance at the level of the adipocyte because of reduced GH receptor (GHR) expression. Subjects and methods: We studied GHR expression in omental and subcutaneous fat tissues from a cohort of 55 women ranging from lean to obese by various adiposity parameters. mRNA levels of total GHR and the dominant-negative truncated GHR1−279 (trGHR) form were assayed by quantitative reverse transcriptase-PCR. Associations between adiposity measures and GHR levels as well as trGHR/GHR ratios were analyzed. Results: Total GHR mRNA expression was 2–3-fold lower in omental as well as subcutaneous adipose tissues of obese compared with lean women (P0.05–0.001). Lean individuals expressed higher GHR mRNA levels in omental fat compared with subcutaneous (P0.01); in obese women, this depot-specific difference was lost. Omental and subcutaneous adipose GHR mRNA levels displayed significant negative correlations with a spectrum of indicators of obesity while, in subcutaneous fat, there was a significantly higher trGHR/GHR ratio with increasing adiposity (P0.05). Conclusion: These results support our hypothesis that, with obesity, there is lower GHR expression in the adipocyte, and suggest one possible explanation why GH supplementation is not an effective treatment for individuals with idiopathic obesity. International Journal of Obesity (2011) 35, 1511 -1519; doi: 10.1038/ijo.2011.23; published online 8 March 2011 Growth hormone (GH)-deficient individuals display increased adiposity that can be effectively reduced by GH therapy because of GH's lipolytic effects. However, similar GH treatments of individuals with idiopathic obesity (not associated with an endocrinopathy/syndrome) have had little success. We hypothesized that this form of obesity may be associated with GH resistance at the level of the adipocyte because of reduced GH receptor (GHR) expression. We studied GHR expression in omental and subcutaneous fat tissues from a cohort of 55 women ranging from lean to obese by various adiposity parameters. mRNA levels of total GHR and the dominant-negative truncated GHR(1-279) (trGHR) form were assayed by quantitative reverse transcriptase-PCR. Associations between adiposity measures and GHR levels as well as trGHR/GHR ratios were analyzed. Total GHR mRNA expression was 2-3-fold lower in omental as well as subcutaneous adipose tissues of obese compared with lean women (P ≤ 0.05-0.001). Lean individuals expressed higher GHR mRNA levels in omental fat compared with subcutaneous (P ≤ 0.01); in obese women, this depot-specific difference was lost. Omental and subcutaneous adipose GHR mRNA levels displayed significant negative correlations with a spectrum of indicators of obesity while, in subcutaneous fat, there was a significantly higher trGHR/GHR ratio with increasing adiposity (P ≤ 0.05). These results support our hypothesis that, with obesity, there is lower GHR expression in the adipocyte, and suggest one possible explanation why GH supplementation is not an effective treatment for individuals with idiopathic obesity. Growth hormone (GH)-deficient individuals display increased adiposity that can be effectively reduced by GH therapy because of GH's lipolytic effects. However, similar GH treatments of individuals with idiopathic obesity (not associated with an endocrinopathy/syndrome) have had little success. We hypothesized that this form of obesity may be associated with GH resistance at the level of the adipocyte because of reduced GH receptor (GHR) expression. We studied GHR expression in omental and subcutaneous fat tissues from a cohort of 55 women ranging from lean to obese by various adiposity parameters. mRNA levels of total GHR and the dominant-negative truncated GHR(1-279) (trGHR) form were assayed by quantitative reverse transcriptase-PCR. Associations between adiposity measures and GHR levels as well as trGHR/GHR ratios were analyzed. Total GHR mRNA expression was 2-3-fold lower in omental as well as subcutaneous adipose tissues of obese compared with lean women (P ≤ 0.05-0.001). Lean individuals expressed higher GHR mRNA levels in omental fat compared with subcutaneous (P ≤ 0.01); in obese women, this depot-specific difference was lost. Omental and subcutaneous adipose GHR mRNA levels displayed significant negative correlations with a spectrum of indicators of obesity while, in subcutaneous fat, there was a significantly higher trGHR/GHR ratio with increasing adiposity (P ≤ 0.05). These results support our hypothesis that, with obesity, there is lower GHR expression in the adipocyte, and suggest one possible explanation why GH supplementation is not an effective treatment for individuals with idiopathic obesity. Objectives: Growth hormone (GH)-deficient individuals display increased adiposity that can be effectively reduced by GH therapy because of GH's lipolytic effects. However, similar GH treatments of individuals with idiopathic obesity (not associated with an endocrinopathy/syndrome) have had little success. We hypothesized that this form of obesity may be associated with GH resistance at the level of the adipocyte because of reduced GH receptor (GHR) expression.Subjects and methods: We studied GHR expression in omental and subcutaneous fat tissues from a cohort of 55 women ranging from lean to obese by various adiposity parameters. mRNA levels of total GHR and the dominant-negative truncated GHR sub(1-279) (trGHR) form were assayed by quantitative reverse transcriptase-PCR. Associations between adiposity measures and GHR levels as well as trGHR/GHR ratios were analyzed. Results: Total GHR mRNA expression was 2-3-fold lower in omental as well as subcutaneous adipose tissues of obese compared with lean women (P less than or equal to 0.05-0.001). Lean individuals expressed higher GHR mRNA levels in omental fat compared with subcutaneous (P less than or equal to 0.01); in obese women, this depot-specific difference was lost. Omental and subcutaneous adipose GHR mRNA levels displayed significant negative correlations with a spectrum of indicators of obesity while, in subcutaneous fat, there was a significantly higher trGHR/GHR ratio with increasing adiposity (P less than or equal to 0.05). Conclusion: These results support our hypothesis that, with obesity, there is lower GHR expression in the adipocyte, and suggest one possible explanation why GH supplementation is not an effective treatment for individuals with idiopathic obesity. |
| Audience | Academic |
| Author | Erman, A Tchernof, A Goodyer, C.G Veilleux, A |
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| Cites_doi | 10.1016/j.ecl.2006.11.005 10.1210/jcem.82.3.3836 10.1016/0024-3205(94)00512-5 10.1016/0026-0495(93)90145-E 10.1038/sj.ijo.0801740 10.1038/ncpendmet0427 10.1203/00006450-199509000-00024 10.1016/S0026-0495(97)90177-3 10.1152/ajpendo.00039.2008 10.1210/jc.2006-1811 10.1038/sj.ijo.0803708 10.1210/mend.11.3.9901 10.1530/eje.0.1340061 10.1210/me.2006-0128 10.1096/fj.03-0678fje 10.1155/2010/513948 10.1152/ajpendo.2001.281.6.E1213 10.1093/abbs/gmq010 10.1210/jc.2005-2631 10.1530/eje.0.1500773 10.1006/mgme.2000.3068 10.1016/S0026-0495(97)90275-4 10.1046/j.1467-789x.2000.00015.x 10.1210/jc.2007-2371 10.1111/j.1365-2265.1989.tb01272.x 10.2144/05382RR05 10.1161/01.ATV.13.2.296 10.1210/jc.2008-1363 10.1016/S0026-0495(98)90268-2 10.1210/jc.2005-1802 10.1152/ajpendo.00312.2004 10.1038/oby.2008.242 10.1111/j.1365-2265.2006.02558.x 10.1210/jc.2004-0501 10.1172/JCI10994 10.1677/JOE-07-0648 10.1210/jc.2008-1357 10.1210/endo.142.5.8170 10.1016/S0022-2275(20)41648-7 |
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| Keywords | human female GH resistance omental fat subcutaneous fat growth hormone receptor Human Obesity Adipose tissue Nutrition Subcutaneous Nutrition disorder Metabolic diseases Omentum Gene expression Resistance Somatotropin Messenger RNA Adenohypophyseal hormone Fat Female Woman Subcutaneous tissue Nutritional status |
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| References | Bengtsson, Brummer, Eden, Bosaeus, Lindstedt (CR1) 1989; 31 Drolet, Richard, Sniderman, Mailloux, Fortier, Huot (CR17) 2008; 32 Johannsson, Bjarnason, Bramnert, Carlsson, Degerblad, Manhem (CR28) 1996; 81 Ballesteros, Leung, Ross, Iismaa, Ho (CR4) 2000; 85 Nam, Lobie (CR6) 2000; 1 Ross, Esposito, Shen, Von Laue, Chew, Dobson (CR16) 1997; 11 Mekala, Tritos (CR12) 2009; 94 Rasmussen, Ho, Kjems, Hilsted (CR23) 1996; 81 LeRoith, Yakar (CR22) 2007; 3 Goodyer, Figueiredo, Krackovitch, De Souza, Manalo, Zogopoulos (CR13) 2001; 281 Higami, Pugh, Page, Allison, Prolla, Weindruch (CR29) 2004; 18 Kopchick, Andry (CR31) 2000; 71 Hoffman, O’Sullivan, Freund, Ho (CR3) 1995; 80 Cali, Caprio (CR32) 2008; 93 Bansch, Dirkes-Kersting, Schulte, Assmann, von Eckardstein (CR44) 1997; 46 Kamel, Margery, Norstedt, Thoren, Lindgren, Bronnegard (CR11) 1995; 38 Harman-Boehm, Bluher, Redel, Sion-Vardy, Ovadia, Avinoach (CR40) 2007; 92 Cuneo, Salomon, Watts, Hesp, Sonksen (CR41) 1993; 42 Denson, Menon, Shaufl, Bajwa, Williams, Karpen (CR33) 2001; 107 Jorgensen, Moller, Krag, Billestrup, Christiansen (CR5) 2007; 36 Zou, Menon, Sperling (CR15) 1997; 46 Garry, Collins, Devlin (CR43) 1996; 134 Kenth, Mergelas, Goodyer (CR46) 2008; 198 Gleeson, Lissett, Shalet (CR26) 2005; 90 Marcus, Bolme, Micha-Johansson, Margery, Bronnegard (CR39) 1994; 54 Fain (CR36) 2010; 2010 Wei, Rhani, Goodyer (CR7) 2006; 91 Zhang, Li, Liu, Sun, Zhang (CR30) 2010; 42 Eden, Wiklund, Oscarsson, Rosen, Bengtsson (CR42) 1993; 13 Laron, Ginsberg, Lilos, Arbiv, Vaisman (CR2) 2006; 65 Beauregard, Utz, Schaub, Nachtigall, Biller, Miller (CR8) 2008; 93 Morisset, Huot, Legare, Tchernof (CR18) 2008; 16 Thimmarayappa, Sun, Schultz, Dejkhamron, Lu, Giallongo (CR34) 2006; 20 Blouin, Nadeau, Mailloux, Daris, Lebel, Luu-The (CR19) 2009; 296 Hellmer, Marcus, Sonnenfeld, Arner (CR38) 1992; 75 Mericq, Medina, Bouwman, Johnson, Godoy, Lopez (CR37) 2009; 71 Goodyer, Zogopoulos, Schwartzbauer, Zheng, Hendy, Menon (CR14) 2001; 142 Mauriege, Despres, Prud’homme, Pouliot, Marcotte, Tremblay (CR35) 1991; 32 Heffernan, Thorburn, Fam, Summers, Conway-Campbell, Waters (CR10) 2001; 25 Fisker, Hansen, Fuglsang, Kristensen, Ovesen, Orskov (CR27) 2004; 150 Bansch, Chen-Haudenschild, Dirkes-Kersting, Schulte, Assmann, von (CR45) 1998; 47 Boot, Engels, Boerma, Krenning, de Muinck Keizer-Schrama (CR9) 1997; 82 Roelen, Koppeschaar, de Vries, Snel, Doerga, Zelissen (CR24) 1997; 82 Bouhours-Nouet, Gatelais, Boux de, Rouleau, Coutant (CR25) 2007; 92 Luu-The, Paquet, Calvo, Cumps (CR20) 2005; 38 Blouin, Blanchette, Richard, Dupont, Luu-The, Tchernof (CR21) 2005; 288 JOL Jorgensen (BFijo201123_CR5) 2007; 36 R Drolet (BFijo201123_CR17) 2008; 32 N Bouhours-Nouet (BFijo201123_CR25) 2007; 92 CG Goodyer (BFijo201123_CR13) 2001; 281 KC Mekala (BFijo201123_CR12) 2009; 94 C Marcus (BFijo201123_CR39) 1994; 54 RJM Ross (BFijo201123_CR16) 1997; 11 AM Cali (BFijo201123_CR32) 2008; 93 V Luu-The (BFijo201123_CR20) 2005; 38 D LeRoith (BFijo201123_CR22) 2007; 3 RC Cuneo (BFijo201123_CR41) 1993; 42 K Blouin (BFijo201123_CR19) 2009; 296 Y Higami (BFijo201123_CR29) 2004; 18 S Fisker (BFijo201123_CR27) 2004; 150 C Beauregard (BFijo201123_CR8) 2008; 93 I Harman-Boehm (BFijo201123_CR40) 2007; 92 K Blouin (BFijo201123_CR21) 2005; 288 G Kenth (BFijo201123_CR46) 2008; 198 A Kamel (BFijo201123_CR11) 1995; 38 MH Rasmussen (BFijo201123_CR23) 1996; 81 LA Denson (BFijo201123_CR33) 2001; 107 JJ Kopchick (BFijo201123_CR31) 2000; 71 D Bansch (BFijo201123_CR44) 1997; 46 M Ballesteros (BFijo201123_CR4) 2000; 85 S Eden (BFijo201123_CR42) 1993; 13 SY Nam (BFijo201123_CR6) 2000; 1 MA Heffernan (BFijo201123_CR10) 2001; 25 P Mauriege (BFijo201123_CR35) 1991; 32 HK Gleeson (BFijo201123_CR26) 2005; 90 Z Zhang (BFijo201123_CR30) 2010; 42 G Johannsson (BFijo201123_CR28) 1996; 81 AM Boot (BFijo201123_CR9) 1997; 82 CA Roelen (BFijo201123_CR24) 1997; 82 BA Bengtsson (BFijo201123_CR1) 1989; 31 V Mericq (BFijo201123_CR37) 2009; 71 J Thimmarayappa (BFijo201123_CR34) 2006; 20 D Bansch (BFijo201123_CR45) 1998; 47 CG Goodyer (BFijo201123_CR14) 2001; 142 L Zou (BFijo201123_CR15) 1997; 46 P Garry (BFijo201123_CR43) 1996; 134 Y Wei (BFijo201123_CR7) 2006; 91 JN Fain (BFijo201123_CR36) 2010; 2010 Z Laron (BFijo201123_CR2) 2006; 65 AS Morisset (BFijo201123_CR18) 2008; 16 DM Hoffman (BFijo201123_CR3) 1995; 80 J Hellmer (BFijo201123_CR38) 1992; 75 |
| References_xml | – volume: 36 start-page: 75 year: 2007 end-page: 88 ident: CR5 article-title: Effects of growth hormone on glucose and fat metabolism in human subjects publication-title: Endocrinol Metab Clin North Am doi: 10.1016/j.ecl.2006.11.005 – volume: 80 start-page: 72 year: 1995 end-page: 77 ident: CR3 article-title: Adults with growth hormone deficiency have abnormal body composition but normal energy metabolism publication-title: J Clin Endocrinol Metab – volume: 85 start-page: 2865 year: 2000 end-page: 2871 ident: CR4 article-title: Distribution and abundance of messenger ribonucleic acid for growth hormone receptor isoforms in human tissues publication-title: J Clin Endocrinol Metab – volume: 82 start-page: 760 year: 1997 end-page: 764 ident: CR24 article-title: Visceral adipose tissue is associated with circulating high affinity growth hormone-binding protein publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.82.3.3836 – volume: 54 start-page: 1335 year: 1994 end-page: 1341 ident: CR39 article-title: Growth hormone increases the lipolytic sensitivity for catecholamines in adipocytes from healthy adults publication-title: Life Sci doi: 10.1016/0024-3205(94)00512-5 – volume: 42 start-page: 1519 year: 1993 end-page: 1523 ident: CR41 article-title: Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency publication-title: Metabolism doi: 10.1016/0026-0495(93)90145-E – volume: 25 start-page: 1442 year: 2001 end-page: 1449 ident: CR10 article-title: Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment publication-title: Int J Obes Relat Metab Disord doi: 10.1038/sj.ijo.0801740 – volume: 3 start-page: 302 year: 2007 end-page: 310 ident: CR22 article-title: Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1 publication-title: Nat Clin Pract Endocrinol Metab doi: 10.1038/ncpendmet0427 – volume: 38 start-page: 418 year: 1995 end-page: 421 ident: CR11 article-title: Growth hormone (GH) treatment up-regulates GH receptor mRNA levels in adipocytes from patients with GH deficiency and Prader-Willi syndrome publication-title: Pediatr Res doi: 10.1203/00006450-199509000-00024 – volume: 46 start-page: 114 year: 1997 end-page: 118 ident: CR15 article-title: Induction of mRNAs for the growth hormone receptor gene during mouse 3T3-L1 preadipocyte differentiation publication-title: Metabolism doi: 10.1016/S0026-0495(97)90177-3 – volume: 296 start-page: E244 year: 2009 end-page: E255 ident: CR19 article-title: Pathways of adipose tissue androgen metabolism in women: depot differences and modulation by adipogenesis publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00039.2008 – volume: 32 start-page: 1625 year: 1991 end-page: 1633 ident: CR35 article-title: Regional variation in adipose tissue lipolysis in lean and obese men publication-title: J Lipid Res – volume: 92 start-page: 2240 year: 2007 end-page: 2247 ident: CR40 article-title: Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2006-1811 – volume: 32 start-page: 283 year: 2008 end-page: 291 ident: CR17 article-title: Hypertrophy and hyperplasia of abdominal adipose tissues in women publication-title: Int J Obes (Lond) doi: 10.1038/sj.ijo.0803708 – volume: 75 start-page: 15 year: 1992 end-page: 20 ident: CR38 article-title: Mechanisms for differences in lipolysis between human subcutaneous and omental fat cells publication-title: J Clin Endocrinol Metab – volume: 11 start-page: 265 year: 1997 end-page: 274 ident: CR16 article-title: A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein publication-title: Mol Endocrinol doi: 10.1210/mend.11.3.9901 – volume: 134 start-page: 61 year: 1996 end-page: 66 ident: CR43 article-title: An open 36-month study of lipid changes with growth hormone in adults: lipid changes following replacement of growth hormone in adult acquired growth hormone deficiency publication-title: Eur J Endocrinol doi: 10.1530/eje.0.1340061 – volume: 20 start-page: 2747 year: 2006 end-page: 2756 ident: CR34 article-title: Inhibition of growth hormone receptor gene expression by saturated fatty acids: role of Kruppel-like zinc finger factor, ZBP-89 publication-title: Mol Endocrinol doi: 10.1210/me.2006-0128 – volume: 81 start-page: 1519 year: 1996 end-page: 1524 ident: CR23 article-title: Serum growth hormone-binding protein in obesity: effect of a short-term, very low calorie diet and diet-induced weight loss publication-title: J Clin Endocrinol Metab – volume: 71 start-page: 89 year: 2009 end-page: 93 ident: CR37 article-title: Expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 enzyme in subcutaneous and visceral adipose tissue of prepubertal children publication-title: Horm Res – volume: 18 start-page: 415 year: 2004 end-page: 417 ident: CR29 article-title: Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restriction publication-title: FASEB J doi: 10.1096/fj.03-0678fje – volume: 2010 start-page: 513948 year: 2010 ident: CR36 article-title: Release of inflammatory mediators by human adipose tissue is enhanced in obesity and primarily by the nonfat cells: a review publication-title: Mediators Inflamm doi: 10.1155/2010/513948 – volume: 281 start-page: E1213 year: 2001 end-page: E1220 ident: CR13 article-title: Characterization of the growth hormone receptor in human dermal fibroblasts and liver during development publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.2001.281.6.E1213 – volume: 42 start-page: 202 year: 2010 end-page: 209 ident: CR30 article-title: Prevention of diet-induced obesity by safflower oil: insights at the levels of PPAR{alpha}, Orexin, and Ghrelin ge publication-title: Acta Biochim Biophys Sin doi: 10.1093/abbs/gmq010 – volume: 92 start-page: 629 year: 2007 end-page: 635 ident: CR25 article-title: The insulin-like growth factor-I response to growth hormone is increased in prepubertal children with obesity and tall stature publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2005-2631 – volume: 150 start-page: 773 year: 2004 end-page: 777 ident: CR27 article-title: Gene expression of the GH receptor in subcutaneous and intraabdominal fat in healthy females: relationship to GH-binding protein publication-title: Eur J Endocrinol doi: 10.1530/eje.0.1500773 – volume: 71 start-page: 293 year: 2000 end-page: 314 ident: CR31 article-title: Growth hormone (GH), GH receptor, and signal transduction publication-title: Mol Genet Metab doi: 10.1006/mgme.2000.3068 – volume: 46 start-page: 1039 year: 1997 end-page: 1043 ident: CR44 article-title: Basal growth hormone levels are positively correlated with high-density lipoprotein cholesterol levels in women publication-title: Metabolism doi: 10.1016/S0026-0495(97)90275-4 – volume: 1 start-page: 73 year: 2000 end-page: 86 ident: CR6 article-title: The mechanism of effect of growth hormone on preadipocyte and adipocyte function publication-title: Obes Rev doi: 10.1046/j.1467-789x.2000.00015.x – volume: 93 start-page: 2063 year: 2008 end-page: 2071 ident: CR8 article-title: Growth hormone decreases visceral fat and improves cardiovascular risk markers in women with hypopituitarism: a randomized, placebo-controlled study publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2007-2371 – volume: 31 start-page: 481 year: 1989 end-page: 490 ident: CR1 article-title: Body composition in acromegaly: the effect of treatment publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.1989.tb01272.x – volume: 38 start-page: 287 year: 2005 end-page: 293 ident: CR20 article-title: Improved real-time RT-PCR method for high-throughput measurements using second derivative calculation and double correction publication-title: Biotechniques doi: 10.2144/05382RR05 – volume: 82 start-page: 2423 year: 1997 end-page: 2428 ident: CR9 article-title: Changes in bone mineral density, body composition, and lipid metabolism during growth hormone (GH) treatment in children with GH deficiency publication-title: J Clin Endocrinol Metab – volume: 13 start-page: 296 year: 1993 end-page: 301 ident: CR42 article-title: Growth hormone treatment of growth hormone-deficient adults results in a marked increase in Lp(a) and HDL cholesterol concentrations publication-title: Arterioscler Thromb doi: 10.1161/01.ATV.13.2.296 – volume: 93 start-page: S31 issue: Suppl 1 year: 2008 end-page: S36 ident: CR32 article-title: Obesity in children and adolescents publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2008-1363 – volume: 47 start-page: 339 year: 1998 end-page: 344 ident: CR45 article-title: Basal growth hormone levels in women are positively correlated with high-density lipoprotein cholesterol and apolipoprotein A-I independently of insulin-like growth factor 1 or insulin publication-title: Metabolism doi: 10.1016/S0026-0495(98)90268-2 – volume: 91 start-page: 1901 year: 2006 end-page: 1908 ident: CR7 article-title: Characterization of growth hormone receptor messenger ribonucleic acid variants in human adipocytes publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2005-1802 – volume: 288 start-page: E398 year: 2005 end-page: E404 ident: CR21 article-title: Expression and activity of steroid aldoketoreductases 1C in omental adipose tissue are positive correlates of adiposity in women publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00312.2004 – volume: 16 start-page: 1487 year: 2008 end-page: 1492 ident: CR18 article-title: Circulating IL-6 concentrations and abdominal adipocyte isoproterenol-stimulated lipolysis in women publication-title: Obesity (Silver Spring) doi: 10.1038/oby.2008.242 – volume: 65 start-page: 114 year: 2006 end-page: 117 ident: CR2 article-title: Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity) publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.2006.02558.x – volume: 81 start-page: 1575 year: 1996 end-page: 1581 ident: CR28 article-title: The individual responsiveness to growth hormone (GH) treatment in GH-deficient adults is dependent on the level of GH-binding protein, body mass index, age, and gender publication-title: J Clin Endocrinol Metab – volume: 90 start-page: 1061 year: 2005 end-page: 1067 ident: CR26 article-title: Insulin-like growth factor-I response to a single bolus of growth hormone is increased in obesity publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2004-0501 – volume: 107 start-page: 1451 year: 2001 end-page: 1458 ident: CR33 article-title: TNF-alpha downregulates murine hepatic growth hormone receptor expression by inhibiting Sp1 and Sp3 binding publication-title: J Clin Invest doi: 10.1172/JCI10994 – volume: 198 start-page: 71 year: 2008 end-page: 82 ident: CR46 article-title: Developmental changes in the human growth hormone receptor and its signal transduction pathways publication-title: J Endocrinol doi: 10.1677/JOE-07-0648 – volume: 94 start-page: 130 year: 2009 end-page: 137 ident: CR12 article-title: Effects of recombinant human growth hormone therapy in obesity in adults: a metaanalysis publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2008-1357 – volume: 142 start-page: 1923 year: 2001 end-page: 1934 ident: CR14 article-title: Organization and evolution of the human growth hormone receptor gene 5′-flanking region publication-title: Endocrinology doi: 10.1210/endo.142.5.8170 – volume: 92 start-page: 629 year: 2007 ident: BFijo201123_CR25 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2005-2631 – volume: 1 start-page: 73 year: 2000 ident: BFijo201123_CR6 publication-title: Obes Rev doi: 10.1046/j.1467-789x.2000.00015.x – volume: 11 start-page: 265 year: 1997 ident: BFijo201123_CR16 publication-title: Mol Endocrinol doi: 10.1210/mend.11.3.9901 – volume: 54 start-page: 1335 year: 1994 ident: BFijo201123_CR39 publication-title: Life Sci doi: 10.1016/0024-3205(94)00512-5 – volume: 3 start-page: 302 year: 2007 ident: BFijo201123_CR22 publication-title: Nat Clin Pract Endocrinol Metab doi: 10.1038/ncpendmet0427 – volume: 80 start-page: 72 year: 1995 ident: BFijo201123_CR3 publication-title: J Clin Endocrinol Metab – volume: 90 start-page: 1061 year: 2005 ident: BFijo201123_CR26 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2004-0501 – volume: 32 start-page: 1625 year: 1991 ident: BFijo201123_CR35 publication-title: J Lipid Res doi: 10.1016/S0022-2275(20)41648-7 – volume: 36 start-page: 75 year: 2007 ident: BFijo201123_CR5 publication-title: Endocrinol Metab Clin North Am doi: 10.1016/j.ecl.2006.11.005 – volume: 296 start-page: E244 year: 2009 ident: BFijo201123_CR19 publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00039.2008 – volume: 134 start-page: 61 year: 1996 ident: BFijo201123_CR43 publication-title: Eur J Endocrinol doi: 10.1530/eje.0.1340061 – volume: 142 start-page: 1923 year: 2001 ident: BFijo201123_CR14 publication-title: Endocrinology doi: 10.1210/endo.142.5.8170 – volume: 2010 start-page: 513948 year: 2010 ident: BFijo201123_CR36 publication-title: Mediators Inflamm doi: 10.1155/2010/513948 – volume: 31 start-page: 481 year: 1989 ident: BFijo201123_CR1 publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.1989.tb01272.x – volume: 42 start-page: 1519 year: 1993 ident: BFijo201123_CR41 publication-title: Metabolism doi: 10.1016/0026-0495(93)90145-E – volume: 75 start-page: 15 year: 1992 ident: BFijo201123_CR38 publication-title: J Clin Endocrinol Metab – volume: 46 start-page: 114 year: 1997 ident: BFijo201123_CR15 publication-title: Metabolism doi: 10.1016/S0026-0495(97)90177-3 – volume: 81 start-page: 1519 year: 1996 ident: BFijo201123_CR23 publication-title: J Clin Endocrinol Metab – volume: 47 start-page: 339 year: 1998 ident: BFijo201123_CR45 publication-title: Metabolism doi: 10.1016/S0026-0495(98)90268-2 – volume: 150 start-page: 773 year: 2004 ident: BFijo201123_CR27 publication-title: Eur J Endocrinol doi: 10.1530/eje.0.1500773 – volume: 288 start-page: E398 year: 2005 ident: BFijo201123_CR21 publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00312.2004 – volume: 71 start-page: 89 year: 2009 ident: BFijo201123_CR37 publication-title: Horm Res – volume: 92 start-page: 2240 year: 2007 ident: BFijo201123_CR40 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2006-1811 – volume: 25 start-page: 1442 year: 2001 ident: BFijo201123_CR10 publication-title: Int J Obes Relat Metab Disord doi: 10.1038/sj.ijo.0801740 – volume: 38 start-page: 418 year: 1995 ident: BFijo201123_CR11 publication-title: Pediatr Res doi: 10.1203/00006450-199509000-00024 – volume: 38 start-page: 287 year: 2005 ident: BFijo201123_CR20 publication-title: Biotechniques doi: 10.2144/05382RR05 – volume: 13 start-page: 296 year: 1993 ident: BFijo201123_CR42 publication-title: Arterioscler Thromb doi: 10.1161/01.ATV.13.2.296 – volume: 94 start-page: 130 year: 2009 ident: BFijo201123_CR12 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2008-1357 – volume: 46 start-page: 1039 year: 1997 ident: BFijo201123_CR44 publication-title: Metabolism doi: 10.1016/S0026-0495(97)90275-4 – volume: 16 start-page: 1487 year: 2008 ident: BFijo201123_CR18 publication-title: Obesity (Silver Spring) doi: 10.1038/oby.2008.242 – volume: 91 start-page: 1901 year: 2006 ident: BFijo201123_CR7 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2005-1802 – volume: 93 start-page: 2063 year: 2008 ident: BFijo201123_CR8 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2007-2371 – volume: 81 start-page: 1575 year: 1996 ident: BFijo201123_CR28 publication-title: J Clin Endocrinol Metab – volume: 107 start-page: 1451 year: 2001 ident: BFijo201123_CR33 publication-title: J Clin Invest doi: 10.1172/JCI10994 – volume: 82 start-page: 760 year: 1997 ident: BFijo201123_CR24 publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.82.3.3836 – volume: 71 start-page: 293 year: 2000 ident: BFijo201123_CR31 publication-title: Mol Genet Metab doi: 10.1006/mgme.2000.3068 – volume: 82 start-page: 2423 year: 1997 ident: BFijo201123_CR9 publication-title: J Clin Endocrinol Metab – volume: 20 start-page: 2747 year: 2006 ident: BFijo201123_CR34 publication-title: Mol Endocrinol doi: 10.1210/me.2006-0128 – volume: 281 start-page: E1213 year: 2001 ident: BFijo201123_CR13 publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.2001.281.6.E1213 – volume: 32 start-page: 283 year: 2008 ident: BFijo201123_CR17 publication-title: Int J Obes (Lond) doi: 10.1038/sj.ijo.0803708 – volume: 18 start-page: 415 year: 2004 ident: BFijo201123_CR29 publication-title: FASEB J doi: 10.1096/fj.03-0678fje – volume: 85 start-page: 2865 year: 2000 ident: BFijo201123_CR4 publication-title: J Clin Endocrinol Metab – volume: 93 start-page: S31 issue: Suppl 1 year: 2008 ident: BFijo201123_CR32 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2008-1363 – volume: 198 start-page: 71 year: 2008 ident: BFijo201123_CR46 publication-title: J Endocrinol doi: 10.1677/JOE-07-0648 – volume: 65 start-page: 114 year: 2006 ident: BFijo201123_CR2 publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.2006.02558.x – volume: 42 start-page: 202 year: 2010 ident: BFijo201123_CR30 publication-title: Acta Biochim Biophys Sin doi: 10.1093/abbs/gmq010 |
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| Snippet | Objectives: Growth hormone (GH)-deficient individuals display increased adiposity that can be effectively reduced by GH therapy because of GH's lipolytic... Objectives: Growth hormone (GH)-deficient individuals display increased adiposity that can be effectively reduced by GH therapy because of GH's lipolytic... Growth hormone (GH)-deficient individuals display increased adiposity that can be effectively reduced by GH therapy because of GH's lipolytic effects. However,... International Journal of Obesity (2011) 35, 1511 -1519; doi: 10.1038/ijo.2011.23; published online 8 March 2011 |
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| SubjectTerms | 631/208/199 692/699/2743/393 692/700/565/238 Adipocytes Adipocytes - metabolism Adipose tissue adiposity Adult Biological and medical sciences Biomarkers Biomarkers - metabolism Body fat Body Mass Index Cohort Studies Cysts Development and progression Epidemiology Female Follicles gene expression Gene Expression Regulation Genetic aspects genetics Growth hormones Health Promotion and Disease Prevention Hormone receptors human growth Humans Hypotheses Internal Medicine Medical sciences Medicine Medicine & Public Health Membrane Proteins Membrane Proteins - genetics Membrane Proteins - metabolism Menstruation messenger RNA Metabolic Diseases metabolism Middle Aged Obesity Obesity - genetics Obesity - metabolism Omentum Omentum - metabolism original-article Ovaries Physiological aspects Public Health Ratios Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger RNA, Messenger - metabolism Somatotropin somatotropin receptors subcutaneous fat Subcutaneous Fat - metabolism therapeutics Thinness Thinness - metabolism women |
| Title | Human growth hormone receptor (GHR) expression in obesity: I. GHR mRNA expression in omental and subcutaneous adipose tissues of obese women |
| URI | https://link.springer.com/article/10.1038/ijo.2011.23 https://www.ncbi.nlm.nih.gov/pubmed/21386804 https://www.proquest.com/docview/916330971 https://www.proquest.com/docview/1034829813 https://www.proquest.com/docview/1663591903 https://www.proquest.com/docview/911934963 |
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