Effects of enzyme inducers efavirenz and tipranavir/ritonavir on the pharmacokinetics of the HIV integrase inhibitor dolutegravir - Song, Ivy; Borland, Julie; Chen, Shuguang; Guta, Phyllis; Lou, Yu; Wilfret, David; Wajima, Toshihiro; Savina, Paul; Peppercorn, Amanda; Castellino, Stephen; Wagner, David; Hosking, Louise; et al. (European journal of clinical pharmacology, 2014)
Keywords: Adult; Aged; Alkynes; Anti-HIV Agents - administration & dosage; Anti-HIV Agents - pharmacokinetics; Anti-HIV Agents - pharmacology; Area Under Curve; Benzoxazines - adverse effects; Benzoxazines - pharmacology; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Clinical Trial; Cross-Over Studies; Cyclopropanes; Drug Combinations; Drug Interactions; Female; Heterocyclic Compounds, 3-Ring - adverse effects; Heterocyclic Compounds, 3-Ring - pharmacokinetics; HIV; HIV Integrase Inhibitors - adverse effects; HIV Integrase Inhibitors - pharmacokinetics; Human immunodeficiency virus; Humans; Male; Medical sciences; Middle Aged; Models, Biological; Oxazines; Pharmacology; Pharmacology. Drug treatments; Pharmacology/Toxicology; Piperazines; Pyridines - administration & dosage; Pyridines - adverse effects; Pyridines - pharmacology; Pyridones; Pyrones - administration & dosage; Pyrones - adverse effects; Pyrones - pharmacology; Ritonavir - administration & dosage; Ritonavir - adverse effects; Ritonavir - pharmacology; Sulfonamides; Young Adult; Drug interaction; Tipranavir; Efavirenz; Dolutegravir; Enzyme inducer; Antiretroviral agent; Benzoxazine derivatives; RNA-directed DNA polymerase; Acetylenic compound; Ritonavir; Non nucleoside compound; Non peptide compound; Integrase inhibitor; Reverse transcriptase inhibitor; Antiviral; Human; Enzyme; Transferases; Enzyme inhibitor; Allosteric inhibitor; Peptidases; Nucleotidyltransferases; Hydrolases; Pharmacokinetics; Protease inhibitor