Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

• Published in: Biological psychiatry (1969) Vol. 83; no. 3; pp. 244 - 253
• Main Authors: Logue, Mark W., van Rooij, Sanne J.H., Dennis, Emily L., Davis, Sarah L., Hayes, Jasmeet P., Stevens, Jennifer S., Densmore, Maria, Haswell, Courtney C., Ipser, Jonathan, Koch, Saskia B.J., Korgaonkar, Mayuresh, Lebois, Lauren A.M., Peverill, Matthew, Baker, Justin T., Boedhoe, Premika S.W., Frijling, Jessie L., Gruber, Staci A., Harpaz-Rotem, Ilan, Jahanshad, Neda, Koopowitz, Sheri, Levy, Ifat, Nawijn, Laura, O’Connor, Lauren, Olff, Miranda, Salat, David H., Sheridan, Margaret A., Spielberg, Jeffrey M., van Zuiden, Mirjam, Winternitz, Sherry R., Wolff, Jonathan D., Wolf, Erika J., Wang, Xin, Wrocklage, Kristen, Abdallah, Chadi G., Bryant, Richard A., Geuze, Elbert, Jovanovic, Tanja, Kaufman, Milissa L., King, Anthony P., Krystal, John H., Lagopoulos, Jim, Bennett, Maxwell, Lanius, Ruth, Liberzon, Israel, McGlinchey, Regina E., McLaughlin, Katie A., Milberg, William P., Miller, Mark W., Ressler, Kerry J., Veltman, Dick J., Stein, Dan J., Thomaes, Kathleen, Thompson, Paul M., Morey, Rajendra A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2018
• Subjects: Adult; Adult Survivors of Child Adverse Events - statistics & numerical data; Amygdala; Amygdala - diagnostic imaging; Amygdala - pathology; Childhood trauma; Cohort Studies; Corpus Striatum - diagnostic imaging; Corpus Striatum - pathology; Female; Gender differences; Hippocampus; Hippocampus - diagnostic imaging; Hippocampus - pathology; Humans; Lateral Ventricles - diagnostic imaging; Lateral Ventricles - pathology; Magnetic Resonance Imaging - statistics & numerical data; Male; Meta-Analysis as Topic; Multicenter Studies as Topic; Neuroimaging - statistics & numerical data; PTSD; Sex Characteristics; Stress Disorders, Post-Traumatic - diagnostic imaging; Stress Disorders, Post-Traumatic - pathology; Structural MRI; Thalamus - diagnostic imaging; Thalamus - pathology; PTSD; Structural MRI; Gender differences; Amygdala; Childhood trauma; Hippocampus

Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)–Enhancing Neu...