Abstinence from Escalation of Cocaine Intake Changes the microRNA Landscape in the Cortico-Accumbal Pathway

• Published in: Biomedicines Vol. 11; no. 5; p. 1368
• Main Authors: Kumaresan, Vidhya, Lim, Yolpanhchana, Juneja, Poorva, Tipton, Allison E., de Guglielmo, Giordano, Carrette, Lieselot L. G., Kallupi, Marsida, Maturin, Lisa, Liu, Ying, George, Olivier, Zhang, Huiping
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.05.2023; MDPI
• Subjects: Abstinence; Addictions; Addictive behaviors; Amphetamines; Animal cognition; Behavior; Biobanks; Biomarkers; Brain; Cocaine; DNA methylation; Drug overdose; Drug self-administration; Drug use; Drug withdrawal; Epigenetics; Gap junctions; Gene expression; Genetic diversity; Glutamatergic transmission; Human subjects; Laboratory animals; MAP kinase; MicroRNA; MicroRNAs; miRNA; Morphine; Nucleus accumbens; outbred heterogeneous stock rats; Post-transcription; Prefrontal cortex; protracted abstinence; rat brain miRNA; RNA sequencing; Signal transduction; small RNA sequencing; Transcriptomics; Withdrawal; United States > US; California; addiction index; rat brain miRNA; prefrontal cortex; outbred heterogeneous stock rats; nucleus accumbens; small RNA sequencing; protracted abstinence

Cocaine administration alters the microRNA (miRNA) landscape in the cortico-accumbal pathway. These changes in miRNA can play a major role in the posttranscriptional regulation of gene expression during withdrawal. This study aimed to investigate the changes in microRNA expression in the cortico-acc...