Tolerability of induction chemotherapy dosing practices in acute myeloid leukemia patients

Highlights • We assess dose capping in patients receiving induction chemotherapy for acute myeloid leukemia. • Dose capping did not impact toxicity rates in those with a BSA > 2 compared to those with a BSA < 2. • Delivery of unadjusted chemotherapy for those with a BSA > 2 is likely safe i...

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Published inLeukemia research Vol. 39; no. 2; pp. 173 - 176
Main Authors Peric, Kaylene M, Reeves, David J
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2015
Subjects
Acute myeloid leukemia
Bacteremia - chemically induced
Bacteremia - epidemiology
Body Surface Area
Dosing
Febrile Neutropenia - chemically induced
Febrile Neutropenia - epidemiology
Female
Hematology, Oncology and Palliative Medicine
Humans
Incidence
Induction Chemotherapy
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - epidemiology
Male
Middle Aged
Mucositis - chemically induced
Mucositis - epidemiology
Nausea - chemically induced
Nausea - epidemiology
Obesity
Retrospective Studies
Vomiting - chemically induced
Vomiting - epidemiology
Dosing
Obesity
Acute myeloid leukemia
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Abstract Highlights • We assess dose capping in patients receiving induction chemotherapy for acute myeloid leukemia. • Dose capping did not impact toxicity rates in those with a BSA > 2 compared to those with a BSA < 2. • Delivery of unadjusted chemotherapy for those with a BSA > 2 is likely safe in hematologic malignancies.
AbstractList •We assess dose capping in patients receiving induction chemotherapy for acute myeloid leukemia.•Dose capping did not impact toxicity rates in those with a BSA>2 compared to those with a BSA<2.•Delivery of unadjusted chemotherapy for those with a BSA>2 is likely safe in hematologic malignancies. For patients with high body surface areas (BSA), differing chemotherapy dosing strategies have been utilized in attempts to reduce toxicity. In a retrospective evaluation, we compared the effects of chemotherapy dosing in acute myeloid leukemia patients with high BSA (>2m2) who received capped doses (n=12) to those who received uncapped doses (n=24), and to patients with BSA≤2m2 (n=42). There were no statistically significant differences among groups (BSA≤2m2, BSA>2m2 capped, and BSA>2m2 uncapped) in the incidences of febrile neutropenia (85.7, 66.7, and 75.0%, respectively, p=0.29), bacteremia (19.0, 8.3, and 16.7%, respectively, p=0.68), mucositis (42.8, 50.0, and 41.7%, respectively, p=0.88) or nausea/vomiting (47.6, 33.3, and 37.5, respectively, p=0.57). Results suggest delivery of unadjusted chemotherapy based on actual body weight is likely safe in hematological malignancies.
Highlights • We assess dose capping in patients receiving induction chemotherapy for acute myeloid leukemia. • Dose capping did not impact toxicity rates in those with a BSA > 2 compared to those with a BSA < 2. • Delivery of unadjusted chemotherapy for those with a BSA > 2 is likely safe in hematologic malignancies.
For patients with high body surface areas (BSA), differing chemotherapy dosing strategies have been utilized in attempts to reduce toxicity. In a retrospective evaluation, we compared the effects of chemotherapy dosing in acute myeloid leukemia patients with high BSA (>2 m super(2)) who received capped doses (n = 12) to those who received uncapped doses (n = 24), and to patients with BSA less than or equal to 2 m super(2) (n = 42). There were no statistically significant differences among groups (BSA less than or equal to 2 m super(2), BSA > 2 m super(2) capped, and BSA > 2 m super(2) uncapped) in the incidences of febrile neutropenia (85.7, 66.7, and 75.0%, respectively, p = 0.29), bacteremia (19.0, 8.3, and 16.7%, respectively, p = 0.68), mucositis (42.8, 50.0, and 41.7%, respectively, p = 0.88) or nausea/vomiting (47.6, 33.3, and 37.5, respectively, p = 0.57). Results suggest delivery of unadjusted chemotherapy based on actual body weight is likely safe in hematological malignancies.
For patients with high body surface areas (BSA), differing chemotherapy dosing strategies have been utilized in attempts to reduce toxicity. In a retrospective evaluation, we compared the effects of chemotherapy dosing in acute myeloid leukemia patients with high BSA (>2m(2)) who received capped doses (n=12) to those who received uncapped doses (n=24), and to patients with BSA≤2m(2) (n=42). There were no statistically significant differences among groups (BSA≤2m(2), BSA>2m(2) capped, and BSA>2m(2) uncapped) in the incidences of febrile neutropenia (85.7, 66.7, and 75.0%, respectively, p=0.29), bacteremia (19.0, 8.3, and 16.7%, respectively, p=0.68), mucositis (42.8, 50.0, and 41.7%, respectively, p=0.88) or nausea/vomiting (47.6, 33.3, and 37.5, respectively, p=0.57). Results suggest delivery of unadjusted chemotherapy based on actual body weight is likely safe in hematological malignancies.
Author Peric, Kaylene M
Reeves, David J
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Issue 2
Keywords Dosing
Obesity
Acute myeloid leukemia
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Snippet Highlights • We assess dose capping in patients receiving induction chemotherapy for acute myeloid leukemia. • Dose capping did not impact toxicity rates in...
•We assess dose capping in patients receiving induction chemotherapy for acute myeloid leukemia.•Dose capping did not impact toxicity rates in those with a...
For patients with high body surface areas (BSA), differing chemotherapy dosing strategies have been utilized in attempts to reduce toxicity. In a retrospective...
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SubjectTerms Acute myeloid leukemia
Bacteremia - chemically induced
Bacteremia - epidemiology
Body Surface Area
Dosing
Febrile Neutropenia - chemically induced
Febrile Neutropenia - epidemiology
Female
Hematology, Oncology and Palliative Medicine
Humans
Incidence
Induction Chemotherapy
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - epidemiology
Male
Middle Aged
Mucositis - chemically induced
Mucositis - epidemiology
Nausea - chemically induced
Nausea - epidemiology
Obesity
Retrospective Studies
Vomiting - chemically induced
Vomiting - epidemiology
Title Tolerability of induction chemotherapy dosing practices in acute myeloid leukemia patients
URI https://www.clinicalkey.es/playcontent/1-s2.0-S0145212614003762
https://dx.doi.org/10.1016/j.leukres.2014.11.024
https://www.ncbi.nlm.nih.gov/pubmed/25542696
https://search.proquest.com/docview/1660407364
Volume 39
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