Natural product-derived phytochemicals as potential agents against coronaviruses: A review

• Published in: Virus research Vol. 284; p. 197989
• Main Authors: Mani, Janice S., Johnson, Joel B., Steel, Jason C., Broszczak, Daniel A., Neilsen, Paul M., Walsh, Kerry B., Naiker, Mani
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.07.2020
• Subjects: Animals; antiviral agents; antiviral properties; Betacoronavirus - drug effects; caffeic acid; Coronaviridae; Coronavirus infections; Coronavirus Infections - drug therapy; Coronavirus, Feline - drug effects; COVID-19; etiological agents; Humans; Infectious bronchitis virus; Infectious bronchitis virus - drug effects; lectins; lycorine; Middle East respiratory syndrome (MERS); Middle East Respiratory Syndrome Coronavirus - drug effects; mortality; myricetin; Pandemics; Phytochemicals - therapeutic use; Pneumonia, Viral - drug therapy; polar compounds; polyphenols; Porcine epidemic diarrhea virus - drug effects; quercetin; SARS-CoV-2; Severe acute respiratory syndrome (SARS); Severe acute respiratory syndrome-related coronavirus - drug effects; therapeutics; toxicity; Traditional medicine; COVID-19; SARS-CoV-2; Middle East respiratory syndrome (MERS); Traditional medicine; Severe acute respiratory syndrome (SARS); Coronaviridae

[Display omitted] •Naturally derived compounds provide a potential wealth of antiviral agents.•We reviewed the literature on phytochemicals against different human and animal coronaviruses.•Compounds showing the greatest potential for drug development are highlighted.•All promising compounds contain...