Fibroblast Activation Protein (FAP)-Mediated Cleavage of Type III Collagen Reveals Serum Biomarker Potential in Non-Small Cell Lung Cancer and Spondyloarthritis

• Published in: Biomedicines Vol. 12; no. 3; p. 545
• Main Authors: Pedersen, Rasmus S., Thorlacius-Ussing, Jeppe, Raimondo, Maria G., Langholm, Lasse L., Schett, Georg, Ramming, Andreas, Karsdal, Morten, Willumsen, Nicholas
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.02.2024; MDPI
• Subjects: Amino acids; Antibodies; Arthritis; Biomarkers; Collagen; Collagen (type III); Enzyme-linked immunosorbent assay; Ethylenediaminetetraacetic acid; Extracellular matrix; extracellular matrix remodeling; Fibroblast activation protein; fibroblast activation protein (FAP); Fibroblasts; Fibrosis; Inflammatory diseases; Lung cancer; Lung cancer, Non-small cell; Lung cancer, Small cell; non-small cell lung cancer (NSCLC); Non-small cell lung carcinoma; Patients; Peptides; Proteins; Proteolysis; Rheumatic diseases; Serine proteinase; serum biomarker; Small cell lung carcinoma; spondyloarthritis; Thrombin; Tumors; Sweden; Germany; Minneapolis Minnesota; St Louis Missouri; United States > US; spondyloarthritis; fibroblast activation protein (FAP); serum biomarker; non-small cell lung cancer (NSCLC); extracellular matrix remodeling

Fibroblast activation protein (FAP) is a known promoter of tumor development and is associated with poor clinical outcome for various cancer types. Being specifically expressed in pathological conditions including multiple types of fibrosis and cancers, FAP is an optimal target for diagnostics and t...