Versatile dopamine-functionalized hyaluronic acid-recombinant human collagen hydrogel promoting diabetic wound healing via inflammation control and vascularization tissue regeneration

• Published in: Bioactive materials Vol. 35; pp. 330 - 345
• Main Authors: Wang, Yong, Zhang, Yuan, Yang, Yun-Peng, Jin, Ming-Yuan, Huang, Sha, Zhuang, Ze-Ming, Zhang, Tao, Cao, Li-Li, Lin, Xiao-Ying, Chen, Jun, Du, Yong-Zhong, Chen, Jian, Tan, Wei-Qiang
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.05.2024; KeAi Publishing Communications Ltd; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Adhesives; Angiogenesis; Antibacterial; Antimicrobial activity; Antioxidant and anti-inflammation; Antioxidants; Biocompatibility; Catechol; Chronic infection; Collagen; Cytotoxicity; Diabetes; Diabetes mellitus; Diabetic wound; Disease management; Dopamine; Effectiveness; Extracellular matrix; Hyaluronic acid; Hyaluronic acid hydrogel; Hydrocarbons; Hydrogels; Hydrogen peroxide; Infections; Inflammation; Mechanical properties; Pore size; Recombinant human collagen; Regeneration (physiology); Rheological properties; Rheology; Skin; Spectrum analysis; Tissue engineering; Vascularization; Wound healing; Wound infection; Hyaluronic acid hydrogel; Antibacterial; Antioxidant and anti-inflammation; Recombinant human collagen; Diabetic wound

The management of chronic wounds in diabetes remains challenging due to the complexity of impaired wound healing, delayed healing, susceptibility to infection, and elevated risk of reopening, highlighting the need for effective chronic wound management with innovative approaches such as multifunctio...