Piezoelectric hydrogel for treatment of periodontitis through bioenergetic activation

• Published in: Bioactive materials Vol. 35; pp. 346 - 361
• Main Authors: Liu, Xin, Wan, Xingyi, Sui, Baiyan, Hu, Quanhong, Liu, Zhirong, Ding, Tingting, Zhao, Jiao, Chen, Yuxiao, Wang, Zhong Lin, Li, Linlin
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.05.2024; KeAi Publishing Communications Ltd; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Adenosine triphosphate; Bioenergetics; Biomedical materials; Bone growth; Bone regeneration; Cell activation; Cell differentiation; Defects; Differentiation (biology); Dimensional analysis; Energy; Energy metabolism; Gelatin; Genotype & phenotype; Gum disease; Hydrogels; Immune system; Immunomodulation; Inflammation; Ligaments; Macrophage polarization; Macrophages; Metabolism; Microenvironments; Mitochondrial bioenergetics; NMR; Nuclear magnetic resonance; Periodontal ligament; Periodontitis; Phenotypes; Piezoelectric hydrogel; Piezoelectricity; Regeneration; Regeneration (physiology); Simulation; Stem cells; Stimulation; Tilapia; Tissue engineering; Ultrasonic imaging; United States > US; Japan; Piezoelectric hydrogel; Periodontitis; Macrophage polarization; Mitochondrial bioenergetics; Bone regeneration

The impaired differentiation ability of resident cells and disordered immune microenvironment in periodontitis pose a huge challenge for bone regeneration. Herein, we construct a piezoelectric hydrogel to rescue the impaired osteogenic capability and rebuild the regenerative immune microenvironment...