In vivo assessment of neuroinflammation in progressive multiple sclerosis: a proof of concept study with [18F]DPA714 PET - Hagens, Marloes H. J.; Golla, Sandeep V.; Wijburg, Martijn T.; Yaqub, Maqsood; Heijtel, Dennis; Steenwijk, Martijn D.; Schober, Patrick; Brevé, John J. P.; Schuit, Robert C.; Reekie, Tristan A.; Kassiou, Michael; van Dam, Anne-Marie; et al. (Journal of neuroinflammation, 2018)
Keywords: [18F]DPA714; Affinity; Binding sites; Biomedical and Life Sciences; Biomedicine; Blood; Blood-brain barrier; Brain - diagnostic imaging; Brain research; Encephalitis - diagnostic imaging; Encephalitis - etiology; Female; Fluorodeoxyglucose F18 - pharmacokinetics; Gene polymorphism; Humans; Immunology; Inflammation; Kinetics; Magnetic Resonance Imaging; Male; Medical imaging; Microglia; Middle Aged; Multiple sclerosis; Multiple Sclerosis - complications; Multiple Sclerosis - diagnostic imaging; Neurobiology; Neuroinflammation; Neurology; Neurosciences; NMR; Nuclear magnetic resonance; Plasma; Polymorphism; Positron emission tomography; Proof of Concept Study; Pyrazoles - pharmacokinetics; Pyrimidines - pharmacokinetics; Statistics, Nonparametric; Studies; Substantia alba; TSPO; TspO gene; F]DPA714; Neuroinflammation; TSPO; Multiple sclerosis; [; Positron emission tomography; [18F]DPA714