Increased Myocyte Content and Mechanical Function Within a Tissue-Engineered Myocardial Patch Following Implantation
During the past few years, studies involving the implantation of stem cells, chemical factors, and scaffolds have demonstrated the ability to augment the mammalian heart's native regenerative capacity. Scaffolds comprised of extracellular matrix (ECM) have been used to repair myocardial defects...
Saved in:
Published in | Tissue engineering. Part A Vol. 15; no. 8; pp. 2189 - 2201 |
---|---|
Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Mary Ann Liebert, Inc
01.08.2009
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | During the past few years, studies involving the implantation of stem cells, chemical factors, and scaffolds have demonstrated the ability to augment the mammalian heart's native regenerative capacity. Scaffolds comprised of extracellular matrix (ECM) have been used to repair myocardial defects. These scaffolds become populated with myocytes and provide regional contractile function, but quantification of the myocyte population has not yet been conducted. The purpose of this study was to quantitate the myocyte content within the ECM bioscaffold and to correlate this cell population with the regional mechanical function over time. Xenogenic ECM scaffolds derived from porcine urinary bladder were implanted into a full-thickness, surgically induced, right ventricular-free wall defect in a dog model. Zero, 2, and 8 weeks following implantation, regional function and myocyte content were determined in each patch region. Regional function did not significantly increase from 0 to 2 weeks. At 8 weeks, however, regional stroke work increased to 3.7 ± 0.7% and systolic contraction increased to 4.4 ± 1.2%. The myocyte content also significantly increased during that period generating a linear relationship between regional function and myocyte content. In conclusion, ECM used as a myocardial patch increases both the regional function and the myocyte content over time. The mechanical function generated in the patch region is correlated with the quantity of local tissue myocytes. |
---|---|
AbstractList | During the past few years, studies involving the implantation of stem cells, chemical factors, and scaffolds have demonstrated the ability to augment the mammalian heart's native regenerative capacity. Scaffolds comprised of extracellular matrix (ECM) have been used to repair myocardial defects. These scaffolds become populated with myocytes and provide regional contractile function, but quantification of the myocyte population has not yet been conducted. The purpose of this study was to quantitate the myocyte content within the ECM bioscaffold and to correlate this cell population with the regional mechanical function over time. Xenogenic ECM scaffolds derived from porcine urinary bladder were implanted into a full-thickness, surgically induced, right ventricular-free wall defect in a dog model. Zero, 2, and 8 weeks following implantation, regional function and myocyte content were determined in each patch region. Regional function did not significantly increase from 0 to 2 weeks. At 8 weeks, however, regional stroke work increased to 3.7 plus or minus 0.7% and systolic contraction increased to 4.4 plus or minus 1.2%. The myocyte content also significantly increased during that period generating a linear relationship between regional function and myocyte content. In conclusion, ECM used as a myocardial patch increases both the regional function and the myocyte content over time. The mechanical function generated in the patch region is correlated with the quantity of local tissue myocytes. During the past few years, studies involving the implantation of stem cells, chemical factors, and scaffolds have demonstrated the ability to augment the mammalian heart's native regenerative capacity. Scaffolds comprised of extracellular matrix (ECM) have been used to repair myocardial defects. These scaffolds become populated with myocytes and provide regional contractile function, but quantification of the myocyte population has not yet been conducted. The purpose of this study was to quantitate the myocyte content within the ECM bioscaffold and to correlate this cell population with the regional mechanical function over time. Xenogenic ECM scaffolds derived from porcine urinary bladder were implanted into a full-thickness, surgically induced, right ventricular-free wall defect in a dog model. Zero, 2, and 8 weeks following implantation, regional function and myocyte content were determined in each patch region. Regional function did not significantly increase from 0 to 2 weeks. At 8 weeks, however, regional stroke work increased to 3.7 +/- 0.7% and systolic contraction increased to 4.4 +/- 1.2%. The myocyte content also significantly increased during that period generating a linear relationship between regional function and myocyte content. In conclusion, ECM used as a myocardial patch increases both the regional function and the myocyte content over time. The mechanical function generated in the patch region is correlated with the quantity of local tissue myocytes. During the past few years, studies involving the implantation of stem cells, chemical factors, and scaffolds have demonstrated the ability to augment the mammalian heart's native regenerative capacity. Scaffolds comprised of extracellular matrix (ECM) have been used to repair myocardial defects. These scaffolds become populated with myocytes and provide regional contractile function, but quantification of the myocyte population has not yet been conducted. The purpose of this study was to quantitate the myocyte content within the ECM bioscaffold and to correlate this cell population with the regional mechanical function over time. Xenogenic ECM scaffolds derived from porcine urinary bladder were implanted into a full-thickness, surgically induced, right ventricular-free wall defect in a dog model. Zero, 2, and 8 weeks following implantation, regional function and myocyte content were determined in each patch region. Regional function did not significantly increase from 0 to 2 weeks. At 8 weeks, however, regional stroke work increased to 3.7 ± 0.7% and systolic contraction increased to 4.4 ± 1.2%. The myocyte content also significantly increased during that period generating a linear relationship between regional function and myocyte content. In conclusion, ECM used as a myocardial patch increases both the regional function and the myocyte content over time. The mechanical function generated in the patch region is correlated with the quantity of local tissue myocytes. During the past few years, studies involving the implantation of stem cells, chemical factors, and scaffolds have demonstrated the ability to augment the mammalian heart's native regenerative capacity. Scaffolds comprised of extracellular matrix (ECM) have been used to repair myocardial defects. These scaffolds become populated with myocytes and provide regional contractile function, but quantification of the myocyte population has not yet been conducted. The purpose of this study was to quantitate the myocyte content within the ECM bioscaffold and to correlate this cell population with the regional mechanical function over time. Xenogenic ECM scaffolds derived from porcine urinary bladder were implanted into a full-thickness, surgically induced, right ventricular-free wall defect in a dog model. Zero, 2, and 8 weeks following implantation, regional function and myocyte content were determined in each patch region. Regional function did not significantly increase from 0 to 2 weeks. At 8 weeks, however, regional stroke work increased to 3.7 +/- 0.7% and systolic contraction increased to 4.4 +/- 1.2%. The myocyte content also significantly increased during that period generating a linear relationship between regional function and myocyte content. In conclusion, ECM used as a myocardial patch increases both the regional function and the myocyte content over time. The mechanical function generated in the patch region is correlated with the quantity of local tissue myocytes. [PUBLICATION ABSTRACT] |
Author | Badylak, Stephen F. Schuldt, Adam J.T. Cohen, Ira S. Rosen, Amy B. Potapova, Irina A. Azeloglu, Evren U. Kelly, Damon J. Kochupura, Paul V. Doronin, Sergey V. Gaudette, Glenn R. Brink, Peter R. |
Author_xml | – sequence: 1 givenname: Damon J. surname: Kelly fullname: Kelly, Damon J. organization: 2Diabetes and Metabolic Diseases Research Program, Stony Brook University, Stony Brook, New York – sequence: 2 givenname: Amy B. surname: Rosen fullname: Rosen, Amy B. organization: 3Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York – sequence: 3 givenname: Adam J.T. surname: Schuldt fullname: Schuldt, Adam J.T. organization: 3Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York – sequence: 4 givenname: Paul V. surname: Kochupura fullname: Kochupura, Paul V. organization: 4Department of Surgery, Stony Brook University, Stony Brook, New York – sequence: 5 givenname: Sergey V. surname: Doronin fullname: Doronin, Sergey V. organization: 5Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York – sequence: 6 givenname: Irina A. surname: Potapova fullname: Potapova, Irina A. organization: 5Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York – sequence: 7 givenname: Evren U. surname: Azeloglu fullname: Azeloglu, Evren U. organization: 6Department of Biomedical Engineering, Columbia University, New York, New York – sequence: 8 givenname: Stephen F. surname: Badylak fullname: Badylak, Stephen F. organization: 7McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania – sequence: 9 givenname: Peter R. surname: Brink fullname: Brink, Peter R. organization: 5Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York – sequence: 10 givenname: Ira S. surname: Cohen fullname: Cohen, Ira S. organization: 5Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York – sequence: 11 givenname: Glenn R. surname: Gaudette fullname: Gaudette, Glenn R. organization: 8Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19231971$$D View this record in MEDLINE/PubMed |
BookMark | eNqNkUtvEzEUhS1URB_wA9igEQtYTerHZOzZIFVRA5GKyqIIdtYdz53E1cQOtgeUf49HiUrLArGwbB9_98j3nnNy4rxDQl4zOmNUNZcJ3SwhzDilakYrQZ-RM9YIWQox_37ycK7YKTmP8Z7SmtZSviCnrOGCNZKdkbRyJiBE7IrPe2_2CYuFd9k4FeCyhmYDzhoYiuXoTLLeFd9s2lhXQHFnYxyxvHZr6xDD0QJCZzP-BZLZFEs_DP6Xdetitd0N4BJMFi_J8x6GiK-O-wX5ury-W3wqb24_rhZXN6WZS5pKYFXfg2SgWiMbbPOtN7xmqu6hb0HWVQNG1fOqVk3T0p7Ldl51WeFgZIdcXJAPB9_d2G6xM7mrAIPeBbuFsNcerH764uxGr_1PzWUluJDZ4P3RIPgfI8aktzYaHHIn6MeoZR60rChTmXz3T5JT2XClWAbf_gXe-zG4PAad41KVEIpmiB0gE3yMAfuHPzOqp-h1Tigv0FP0eoo-17x53OyfimPWGZAHYJLBucFiiyH9h_Vvct7DXA |
CitedBy_id | crossref_primary_10_34133_research_0161 crossref_primary_10_1007_s10439_019_02408_9 crossref_primary_10_1038_s41467_021_24921_z crossref_primary_10_1016_j_actbio_2016_08_031 crossref_primary_10_1002_term_1460 crossref_primary_10_1007_s10856_014_5234_0 crossref_primary_10_1101_cshperspect_a025676 crossref_primary_10_1517_14712598_2011_578574 crossref_primary_10_1016_j_jtcvs_2014_02_081 crossref_primary_10_1021_acsbiomaterials_7b00083 crossref_primary_10_1016_j_addr_2012_08_010 crossref_primary_10_1016_j_biomaterials_2014_06_015 crossref_primary_10_3390_cryst10060438 crossref_primary_10_1016_j_compstruc_2010_12_012 crossref_primary_10_1016_j_copbio_2011_04_004 crossref_primary_10_1007_s11886_010_0098_5 crossref_primary_10_1007_s12015_011_9325_8 crossref_primary_10_1002_jbm_a_35000 crossref_primary_10_4161_org_25394 crossref_primary_10_1089_ten_tea_2011_0036 crossref_primary_10_2522_ptj_20150133 crossref_primary_10_14814_phy2_12351 crossref_primary_10_1016_j_compstruc_2012_11_016 crossref_primary_10_1186_s13287_015_0237_4 crossref_primary_10_1089_ten_tec_2012_0334 crossref_primary_10_1007_s00104_010_2032_1 crossref_primary_10_1097_MAT_0000000000000864 crossref_primary_10_1021_acsbiomaterials_6b00547 crossref_primary_10_1002_jbm_b_32770 crossref_primary_10_1016_j_jss_2010_07_017 crossref_primary_10_1016_j_jtcvs_2012_03_009 crossref_primary_10_1016_j_actbio_2013_09_006 crossref_primary_10_1089_ten_tea_2012_0475 |
Cites_doi | 10.1016/S0301-472X(01)00729-9 10.1126/science.1077857 10.1016/j.bbrc.2003.11.143 10.1152/ajpcell.00280.2003 10.1089/ten.2006.0447 10.1161/CIRCULATIONAHA.104.524355 10.1038/35070587 10.1532/hsf.917 10.1161/CIRCULATIONAHA.106.657270 10.1016/S0735-1097(01)01119-6 10.1161/01.CIR.0000019361.34897.75 10.1007/s00429-002-0249-6 10.1056/NEJM200106073442303 10.1073/pnas.0504388102 10.1161/CIRCULATIONAHA.106.668707 10.1161/CIRCULATIONAHA.104.534214 10.1016/S0022-2828(84)80038-3 10.1067/mtc.2002.127449 10.1161/01.RES.67.6.1427 10.1016/j.medengphy.2006.01.001 10.1161/01.CIR.0000147780.30124.CF 10.3727/000000006783982368 10.1023/A:1023894031701 10.1038/nbt1117 10.1038/nm1684 |
ContentType | Journal Article |
Copyright | 2009, Mary Ann Liebert, Inc. (©) Copyright 2009, Mary Ann Liebert, Inc. Copyright 2009, Mary Ann Liebert, Inc. |
Copyright_xml | – notice: 2009, Mary Ann Liebert, Inc. – notice: (©) Copyright 2009, Mary Ann Liebert, Inc. – notice: Copyright 2009, Mary Ann Liebert, Inc. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QP 7T5 7TK 7TM 7TO 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M2P M7P PQEST PQQKQ PQUKI PRINS Q9U 7QO 8FD FR3 P64 7X8 5PM |
DOI | 10.1089/ten.tea.2008.0430 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest Science Journals Biological Science Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Biotechnology Research Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Central Essentials Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection AIDS and Cancer Research Abstracts ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest Central (Alumni) Engineering Research Database Biotechnology Research Abstracts Technology Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
DatabaseTitleList | Engineering Research Database MEDLINE ProQuest Central Student |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Engineering |
EISSN | 1937-335X |
EndPage | 2201 |
ExternalDocumentID | 2020248601 10_1089_ten_tea_2008_0430 19231971 |
Genre | Journal Article Research Support, N.I.H., Extramural |
GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: R01 HL067101 – fundername: NIGMS NIH HHS grantid: T32 GM008444 – fundername: NIDDK NIH HHS grantid: T32 DK007521 – fundername: NIBIB NIH HHS grantid: R01 EB000261 – fundername: NHLBI NIH HHS grantid: HL67101 – fundername: NHLBI NIH HHS grantid: HL28958 – fundername: NHLBI NIH HHS grantid: R01 HL067101-08 – fundername: NIBIB NIH HHS grantid: EB000261 – fundername: NHLBI NIH HHS grantid: P01 HL028958-25 – fundername: NHLBI NIH HHS grantid: P01 HL028958-21 |
GroupedDBID | --- 0R~ 123 29Q 3V. 4.4 53G 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ ABBKN ABUWG ACGFO ACGOD ACPRK AENEX AFKRA AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AZQEC BBNVY BENPR BHPHI BPHCQ BVXVI CAG CCPQU COF CS3 DU5 DWQXO EBS EJD F5P FYUFA GNUQQ HCIFZ HMCUK IAO IER IGS IHR ITC LK8 M0L M1P M2P M7P MV1 NQHIM O9- PQQKQ PROAC PSQYO RML RNS UE5 UKHRP 1-M CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QP 7T5 7TK 7TM 7TO 7XB 8FK H94 K9. PQEST PQUKI PRINS Q9U 7QO 8FD FR3 P64 7X8 5PM |
ID | FETCH-LOGICAL-c570t-a14ffa71a8bc79eb4fffc26186fafba7649ac86546899b0f27b54dc862ac7de23 |
IEDL.DBID | BENPR |
ISSN | 1937-3341 |
IngestDate | Tue Sep 17 21:24:55 EDT 2024 Sat Aug 17 01:47:18 EDT 2024 Sat Aug 17 01:46:45 EDT 2024 Thu Oct 10 19:18:16 EDT 2024 Fri Aug 23 01:04:44 EDT 2024 Sat Sep 28 07:54:22 EDT 2024 Fri Sep 27 01:18:59 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 8 |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c570t-a14ffa71a8bc79eb4fffc26186fafba7649ac86546899b0f27b54dc862ac7de23 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743237 |
PMID | 19231971 |
PQID | 193843380 |
PQPubID | 40309 |
PageCount | 13 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2743237 proquest_miscellaneous_733574018 proquest_miscellaneous_20792881 proquest_journals_193843380 crossref_primary_10_1089_ten_tea_2008_0430 pubmed_primary_19231971 maryannliebert_primary_10_1089_ten_tea_2008_0430 |
PublicationCentury | 2000 |
PublicationDate | 2009-08-01 |
PublicationDateYYYYMMDD | 2009-08-01 |
PublicationDate_xml | – month: 08 year: 2009 text: 2009-08-01 day: 01 |
PublicationDecade | 2000 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: New Rochelle – name: 140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA |
PublicationTitle | Tissue engineering. Part A |
PublicationTitleAlternate | Tissue Eng Part A |
PublicationYear | 2009 |
Publisher | Mary Ann Liebert, Inc |
Publisher_xml | – name: Mary Ann Liebert, Inc |
References | Badylak, Kochupura, Cohen, Doronin, Saltman, Gilbert, Kelly, Ignotz, Gaudette (B8) 2006; 15 Suppl 1 Cohn, Edmunds (B3) 2003 Oberpriller, Ferrans, Carroll (B21) 1984; 16 Badylak, Park, Peppas, McCabe, Yoder (B23) 2001; 29 Matsubara, Tsutsumi, Pan, Hiraoka, Oda, Nishimura, Kawaguchi, Nakamura, Kato (B25) 2004; 313 Polte, Eichler, Wang, Ingber (B26) 2004; 286 Ozawa, Mickle, Weisel, Koyama, Wong, Ozawa, Li (B2) 2002; 124 Robinson, Li, Mathison, Redkar, Cui, Chronos, Matheny, Badylak (B7) 2005; 112 Gaudette, Azeloglu, Oleszak, Saltman, Krukenkamp, Chiang (B10) 2002; 2 Ozawa, Mickle, Weisel, Koyama, Ozawa, Li (B5) 2002; 106 Rumëiìanëtìsev, Carlson (B22) 1991 Amado, Saliaris, Schuleri, John, Xie, Cattaneo, Durand, Fitton, Kuang, Stewart, Lehrke, Baumgartner, Martin, Heldman, Hare (B13) 2005; 102 Orlic, Kajstura, Chimenti, Jakoniuk, Anderson, Li, Pickel, McKay, Nadal-Ginard, Bodine, Leri, Anversa (B14) 2001; 410 Poss, Wilson, Keating (B18) 2002; 298 Laflamme, Murry (B11) 2005; 23 Abbott, Huang, Liu, Hickey, Krause, Giordano (B24) 2004; 110 Beltrami, Urbanek, Kajstura, Yan, Finato, Bussani, Nadal-Ginard, Silvestri, Leri, Beltrami, Anversa (B20) 2001; 344 Badylak, Obermiller, Geddes, Matheny (B4) 2003; 6 Feneley, Elbeery, Gaynor, Gall, Davis, Rankin (B9) 1990; 67 Kelly, Azeloglu, Kochupura, Sharma, Gaudette (B12) 2007; 29 Wall, Walker, Healy, Ratcliffe, Guccione (B16) 2006; 114 Ott, Matthiesen, Goh, Black, Kren, Netoff, Taylor (B19) 2008; 14 Cortes-Morichetti, Frati, Schussler, van Huyen, Lauret, Genovese, Carpentier, Chachques (B27) 2007; 13 Kochupura, Azeloglu, Kelly, Doronin, Badylak, Krukenkamp, Cohen, Gaudette (B6) 2005; 112 Flink (B17) 2002; 205 Athanasuleas, Stanley, Buckberg, Dor, DiDonato, Blackstone (B1) 2001; 37 Gaudette, Cohen (B15) 2006; 114 15533866 - Circulation. 2004 Nov 23;110(21):3300-5 16159807 - Circulation. 2005 Aug 30;112(9 Suppl):I144-9 11396441 - N Engl J Med. 2001 Jun 7;344(23):1750-7 2245504 - Circ Res. 1990 Dec;67(6):1427-36 12107494 - Anat Embryol (Berl). 2002 Jun;205(3):235-44 11287958 - Nature. 2001 Apr 5;410(6829):701-5 16061805 - Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11474-9 16159805 - Circulation. 2005 Aug 30;112(9 Suppl):I135-43 14697217 - Biochem Biophys Res Commun. 2004 Jan 16;313(3):503-8 11300423 - J Am Coll Cardiol. 2001 Apr;37(5):1199-209 12447182 - J Thorac Cardiovasc Surg. 2002 Dec;124(6):1157-64 12481136 - Science. 2002 Dec 13;298(5601):2188-90 12354729 - Circulation. 2002 Sep 24;106(12 Suppl 1):I176-82 16826793 - Cell Transplant. 2006;15 Suppl 1:S29-40 17130342 - Circulation. 2006 Dec 12;114(24):2627-35 14761883 - Am J Physiol Cell Physiol. 2004 Mar;286(3):C518-28 17691866 - Tissue Eng. 2007 Nov;13(11):2681-7 12716647 - Heart Surg Forum. 2003;6(2):E20-6 11698127 - Exp Hematol. 2001 Nov;29(11):1310-8 18193059 - Nat Med. 2008 Feb;14(2):213-21 16531092 - Med Eng Phys. 2007 Jan;29(1):154-62 6533317 - J Mol Cell Cardiol. 1984 Dec;16(12):1119-26 16003373 - Nat Biotechnol. 2005 Jul;23(7):845-56 17159071 - Circulation. 2006 Dec 12;114(24):2575-7 B20 B21 B22 B23 B24 B25 B26 B27 Kochupura P.V. (B6) 2005; 112 B10 B11 B12 B13 B14 B15 B16 B17 B18 B19 B1 B2 B3 B4 B5 B7 B8 B9 |
References_xml | – volume: 29 start-page: 154 year: 2007 ident: B12 article-title: Accuracy and reproducibility of a subpixel extended phase correlation method to determine micron level displacements in the heart publication-title: Med Eng Phys contributor: fullname: Gaudette – volume: 14 start-page: 213 year: 2008 ident: B19 article-title: Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart publication-title: Nat Med contributor: fullname: Taylor – volume: 205 start-page: 235 year: 2002 ident: B17 article-title: Cell cycle reentry of ventricular and atrial cardiomyocytes and cells within the epicardium following amputation of the ventricular apex in the axolotl, Amblystoma mexicanum: confocal microscopic immunofluorescent image analysis of bromodeoxyuridine-labeled nuclei publication-title: Anat Embryol (Berl) contributor: fullname: Flink – volume: 15 Suppl 1 start-page: S29 year: 2006 ident: B8 article-title: The use of extracellular matrix as an inductive scaffold for the partial replacement of functional myocardium publication-title: Cell Transplant contributor: fullname: Gaudette – volume: 298 start-page: 2188 year: 2002 ident: B18 article-title: Heart regeneration in zebrafish publication-title: Science contributor: fullname: Keating – volume: 114 start-page: 2627 year: 2006 ident: B16 article-title: Theoretical impact of the injection of material into the myocardium: a finite element model simulation publication-title: Circulation contributor: fullname: Guccione – volume: 410 start-page: 701 year: 2001 ident: B14 article-title: Bone marrow cells regenerate infarcted myocardium publication-title: Nature contributor: fullname: Anversa – volume: 286 start-page: C518 year: 2004 ident: B26 article-title: Extracellular matrix controls myosin light chain phosphorylation and cell contractility through modulation of cell shape and cytoskeletal prestress publication-title: Am J Physiol Cell Physiol contributor: fullname: Ingber – volume: 16 start-page: 1119 year: 1984 ident: B21 article-title: DNA synthesis in rat atrial myocytes as a response to left ventricular infarction. An autoradiographic study of enzymatically dissociated myocytes publication-title: J Mol Cell Cardiol contributor: fullname: Carroll – year: 2003 ident: B3 article-title: Cardiac Surgery in the Adult contributor: fullname: Edmunds – volume: 112 start-page: I135 year: 2005 ident: B7 article-title: Extracellular matrix scaffold for cardiac repair publication-title: Circulation contributor: fullname: Badylak – volume: 102 start-page: 11474 year: 2005 ident: B13 article-title: Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction publication-title: Proc Natl Acad Sci USA contributor: fullname: Hare – volume: 106 start-page: I176 year: 2002 ident: B5 article-title: Optimal biomaterial for creation of autologous cardiac grafts publication-title: Circulation contributor: fullname: Li – volume: 114 start-page: 2575 year: 2006 ident: B15 article-title: Cardiac regeneration: materials can improve the passive properties of myocardium, but cell therapy must do more publication-title: Circulation contributor: fullname: Cohen – volume: 344 start-page: 1750 year: 2001 ident: B20 article-title: Evidence that human cardiac myocytes divide after myocardial infarction publication-title: N Engl J Med contributor: fullname: Anversa – volume: 37 start-page: 1199 year: 2001 ident: B1 article-title: Surgical anterior ventricular endocardial restoration (SAVER) in the dilated remodeled ventricle after anterior myocardial infarction. RESTORE group. Reconstructive endoventricular surgery, returning Torsion original radius elliptical shape to the LV publication-title: J Am Coll Cardiol contributor: fullname: Blackstone – volume: 29 start-page: 1310 year: 2001 ident: B23 article-title: Marrow-derived cells populate scaffolds composed of xenogeneic extracellular matrix publication-title: Exp Hematol contributor: fullname: Yoder – volume: 112 start-page: I144 year: 2005 ident: B6 article-title: Tissue-engineered myocardial patch derived from extracellular matrix provides regional mechanical function publication-title: Circulation contributor: fullname: Gaudette – volume: 2 start-page: 129 year: 2002 ident: B10 article-title: Determination of regional area stroke work with high spatial resolution in the heart publication-title: Cardiovasc Eng Int J contributor: fullname: Chiang – volume: 110 start-page: 3300 year: 2004 ident: B24 article-title: Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury publication-title: Circulation contributor: fullname: Giordano – volume: 13 start-page: 2681 year: 2007 ident: B27 article-title: Association between a cell-seeded collagen matrix and cellular cardiomyoplasty for myocardial support and regeneration publication-title: Tissue Eng contributor: fullname: Chachques – volume: 23 start-page: 845 year: 2005 ident: B11 article-title: Regenerating the heart publication-title: Nat Biotechnol contributor: fullname: Murry – volume: 124 start-page: 1157 year: 2002 ident: B2 article-title: Histologic changes of nonbiodegradable and biodegradable biomaterials used to repair right ventricular heart defects in rats publication-title: J Thorac Cardiovasc Surg contributor: fullname: Li – volume: 313 start-page: 503 year: 2004 ident: B25 article-title: A new technique to expand human mesenchymal stem cells using basement membrane extracellular matrix publication-title: Biochem Biophys Res Commun contributor: fullname: Kato – year: 1991 ident: B22 article-title: Growth and Hyperplasia of Cardiac Muscle Cells contributor: fullname: Carlson – volume: 6 start-page: E20 year: 2003 ident: B4 article-title: Extracellular matrix for myocardial repair publication-title: Heart Surg Forum contributor: fullname: Matheny – volume: 67 start-page: 1427 year: 1990 ident: B9 article-title: Ellipsoidal shell subtraction model of right ventricular volume. Comparison with regional free wall dimensions as indexes of right ventricular function publication-title: Circ Res contributor: fullname: Rankin – ident: B23 doi: 10.1016/S0301-472X(01)00729-9 – ident: B18 doi: 10.1126/science.1077857 – ident: B25 doi: 10.1016/j.bbrc.2003.11.143 – ident: B3 – ident: B26 doi: 10.1152/ajpcell.00280.2003 – ident: B27 doi: 10.1089/ten.2006.0447 – volume: 112 start-page: I144 year: 2005 ident: B6 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.104.524355 contributor: fullname: Kochupura P.V. – ident: B14 doi: 10.1038/35070587 – ident: B4 doi: 10.1532/hsf.917 – ident: B16 doi: 10.1161/CIRCULATIONAHA.106.657270 – ident: B1 doi: 10.1016/S0735-1097(01)01119-6 – ident: B5 doi: 10.1161/01.CIR.0000019361.34897.75 – ident: B17 doi: 10.1007/s00429-002-0249-6 – ident: B20 doi: 10.1056/NEJM200106073442303 – ident: B13 doi: 10.1073/pnas.0504388102 – ident: B22 – ident: B15 doi: 10.1161/CIRCULATIONAHA.106.668707 – ident: B7 doi: 10.1161/CIRCULATIONAHA.104.534214 – ident: B21 doi: 10.1016/S0022-2828(84)80038-3 – ident: B2 doi: 10.1067/mtc.2002.127449 – ident: B9 doi: 10.1161/01.RES.67.6.1427 – ident: B12 doi: 10.1016/j.medengphy.2006.01.001 – ident: B24 doi: 10.1161/01.CIR.0000147780.30124.CF – ident: B8 doi: 10.3727/000000006783982368 – ident: B10 doi: 10.1023/A:1023894031701 – ident: B11 doi: 10.1038/nbt1117 – ident: B19 doi: 10.1038/nm1684 |
SSID | ssj0060677 |
Score | 2.1633248 |
Snippet | During the past few years, studies involving the implantation of stem cells, chemical factors, and scaffolds have demonstrated the ability to augment the... |
SourceID | pubmedcentral proquest crossref pubmed maryannliebert |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 2189 |
SubjectTerms | Animals Biochemistry Cell Cycle Cell Proliferation Dogs Extracellular Matrix - transplantation Heart surgery Mechanical Phenomena Muscle Cells - cytology Muscle Cells - metabolism Myocardium - metabolism Myocardium - pathology Original Original Articles Prosthesis Implantation Regeneration Staining and Labeling Stem cells Sus scrofa Time Factors Tissue Engineering Tissue Scaffolds Urinary Bladder - transplantation Ventricular Pressure |
Title | Increased Myocyte Content and Mechanical Function Within a Tissue-Engineered Myocardial Patch Following Implantation |
URI | https://www.liebertpub.com/doi/abs/10.1089/ten.tea.2008.0430 https://www.ncbi.nlm.nih.gov/pubmed/19231971 https://www.proquest.com/docview/193843380 https://search.proquest.com/docview/20792881 https://search.proquest.com/docview/733574018 https://pubmed.ncbi.nlm.nih.gov/PMC2743237 |
Volume | 15 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELZoewGpiHdDofjACSk0Dzu2TwhQVxVSqwq1Ym-Rn9qVkFPYVKj_npnEWXYRIA45JH4k8YzHXzKfZwh5bZQVwrEiNzr4nAnOc-OYy3njndSO2zCQx8_Om9Mr9mnO54mbs0q0yskmDobadRb_kR8D0JAMvqeKd9ffckwahc7VlEFjh-xVJUMv7d6Hk_OLz5MpbjA82uhWhpkE9npya0p1DIj0LQxjYlMyZEFvLEz7uG9Mxwg4EPnNf4Kfv7MoN5al2QNyP-FJ-n5UgIfkjo-PyL2NKIOPSQ82AKnn3tGz287e9p4OMaliT3WEax43_6Ks6AwWORQU_bLsF8tINb0c5JJP_aUuBq36Si_AjC_oDDSp-wF3ohhpWI9bmeITcjU7ufx4mqdkC7nlouhzXbIQtCi1NFYob-As2Aqj6QcdjBYNU9pK3PoEX2imCJUwnDm4UmkrnK_qp2Q3dtEfEFo5BUCudgANAnPcqyYIi0NsS-cd0xl5M410ez3G1GgHX7hULbw8HDplx4Q2GSm2ZfE_TQ4nabVpRq7atf5k5NW6FKYS-kd09N3NCjoQqpKyzAj9Sw1R1xxTGMqMPBuF_-tpECkrAY3FllqsK2Ac7-2SuFwM8bwrQHFVLZ7_87EPyd3RkYXcwxdkt_9-418CHurNEdkRc3GUdP8nMrwRIA |
link.rule.ids | 230,315,786,790,891,12083,21416,27955,27956,31752,31753,33777,33778,43343,43838,74100,74657 |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lj9MwELZgOQASiNdCWGB94IRkNk3s2D4hhKgKbFccuqK3yPFDrYSchWaF9t8zkzilRYA45JA4dhLPePw583mGkJeNtlI6nrPGBM-4FII1jjsmKu-UccKGnjw-P6tm5_zjUiwTN2eTaJWjTewNtWst_iM_AaChOKyn8jcX3xgmjULnasqgcZ3cgCKOai6X2_VWhcHRBqcyjCOw1qNTU-kTwKOvoRMTl5IjB3pnWrqDu8ZMjIACkd38J_D5O4dyZ1Ka3iN3E5qkbwfx3yfXfHxAbu_EGHxIOrAASDz3js6vWnvVedpHpIodNRGuedz6i5KiU5jiUEz0y7pbrSM1dNFLhY3tpSZ6nfpKP4MRX9Ep6FH7A55EMc6wGTYyxUfkfPp-8W7GUqoFZoXMO2YmPAQjJ0Y1VmrfwFmwBcbSDyY0RlZcG6tw4xOsz5o8FLIR3MGVwljpfFEekoPYRv-E0MJpgHGlA2AQuBNeV0Fa7GI7cd5xk5FXY0_XF0NEjbr3hCtdw8fDYVJuTKiTkXxfFv9T5WiUVp3G46beak9GjrelMJDQO2Kiby830IDUhVKTjNC_3CHLUmACQ5WRx4Pwf70N4mQtobLcU4vtDRjFe78krld9NO8CMFxRyqf_fO1jcnO2mJ_Wpx_OPh2RW4NLC1mIz8hB9_3SPwdk1DUvev3_CTFoEcA |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELagSAgkEG9CgfrACclsNrHj-IQQEJVHqx5asbfIT-1KyClsKtR_z0ziLLsIEIcc8rDjeMbjz5nPM4S8MMpK6XjOjA6ecSkEM447Jirvau2EDQN5_Oi4OjzjHxdikUIKrROtcrKJg6F2ncV_5DMAGjWH9VQ-C4kVcfKueX3-jWECKXS0pmwaV8k1mCRzzOIgF5u1V4WB0kYHM4wpsNyTg7NWM8Cmr6BDE6-SIx96a4q6hTvIdIyACJHp_Ccg-jufcmuCau6Q2wlZ0jejKtwlV3y8R25uxRu8T3qwBkhC944eXXb2svd0iE4Ve6ojXPO4DRilRhuY7lBk9MuqX64i1fR0kBCb6ktVDPr1lZ6AQV_SBnSq-wFvohhzWI-bmuIDcta8P317yFLaBWaFzHum5zwELee6NlYqb-As2ALj6gcdjJYVV9rWuAkK1momD4U0gju4UmgrnS_Kh2QvdtE_JrRwCiBd6QAkBO6EV1WQFrvYzp13XGfk5dTT7fkYXaMdvOK1auHj4dApTyaUyUi-K4v_KbI_SatNY3PdbjQpIwebuzCo0FOio-8u1lCBVEVdzzNC__KELEuByQzrjDwahf-rNYiZlYTCckctNg9gRO_dO3G1HCJ7F4DnilI--WezD8h1UP3284fjT_vkxujdQkLiU7LXf7_wzwAk9eb5oP4_AbQpFew |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Increased+Myocyte+Content+and+Mechanical+Function+Within+a+Tissue-Engineered+Myocardial+Patch+Following+Implantation&rft.jtitle=Tissue+engineering.+Part+A&rft.au=Kelly%2C+D+J&rft.au=Rosen%2C+AB&rft.au=Schuldt%2C+AJT&rft.au=Kochupura%2C+P+V&rft.date=2009-08-01&rft.issn=1937-3341&rft.volume=15&rft.issue=8&rft.spage=2189&rft.epage=2201&rft_id=info:doi/10.1089%2Ften.tea.2008.0430&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1937-3341&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1937-3341&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1937-3341&client=summon |