Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity - Lim, Yun-Ping; Cheng, Ching-Hao; Chen, Wei-Cheng; Chang, Shih-Yu; Hung, Dong-Zong; Chen, Jih-Jung; Wan, Lei; Ma, Wei-Chih; Lin, Yu-Hsien; Chen, Cing-Yu; Yokoi, Tsuyoshi; Nakajima, Miki; et al. (Archives of Toxicology, 2015)
Keywords: Acetaminophen; Acetaminophen - metabolism; Acetaminophen - toxicity; Amiodarone; Amiodarone - metabolism; Amiodarone - toxicity; Animals; Biomedical and Life Sciences; Biomedicine; Blotting, Western; Cell Differentiation; Cell Differentiation - drug effects; Cell Line, Tumor; Cell Survival; Cell Survival - drug effects; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2B6 - genetics; Cytochrome P-450 CYP2B6 - metabolism; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A - genetics; Cytochrome P-450 CYP3A - metabolism; Cytotoxicity; Drug therapy; Environmental Health; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Enzymologic - drug effects; Humans; Isothiocyanates; Isothiocyanates - pharmacology; Mice; Molecular Toxicology; Neurons; Occupational Medicine/Industrial Medicine; Pharmacology/Toxicology; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Steroid; Receptors, Steroid - antagonists & inhibitors; Receptors, Steroid - genetics; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation; Transfection; Inducer–drug interaction; Drug-induced cytotoxicity; Pregnane X receptor; Allyl isothiocyanate; Constitutive androstane receptor; Cytochrome P450 3A4; Cytochrome P450 2B6