Effects of FK228, a novel histone deacetylase inhibitor, on tumor growth and expression of p21 and c-myc genes in vivo - Sasakawa, Yuka; Naoe, Yoshinori; Inoue, Takeshi; Sasakawa, Tatsuya; Matsuo, Masahiko; Manda, Toshitaka; Mutoh, Seitaro (Cancer letters, 2003)
Keywords: Acetylation - drug effects; Adenocarcinoma - drug therapy; Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Adrenal Gland Neoplasms - metabolism; Adrenal Gland Neoplasms - pathology; Angiogenesis; Animals; Biological and medical sciences; c-myc; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Renal Cell - metabolism; Carcinoma, Renal Cell - pathology; Carcinoma, Small Cell - metabolism; Carcinoma, Small Cell - pathology; Cell cycle; Cyclin-Dependent Kinase Inhibitor p21; Cyclins - biosynthesis; Cyclins - genetics; Depsipeptides; Enzyme Inhibitors - pharmacology; Enzyme Inhibitors - therapeutic use; FK228; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Genes, myc; Histone Deacetylase Inhibitors; Humans; Kidney Neoplasms - metabolism; Kidney Neoplasms - pathology; Lung cancer; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Male; Medical sciences; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins - antagonists & inhibitors; Neoplasm Proteins - biosynthesis; Neoplasm Proteins - genetics; p21; Peptides, Cyclic - pharmacology; Peptides, Cyclic - therapeutic use; Pheochromocytoma - metabolism; Pheochromocytoma - pathology; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Protein Processing, Post-Translational - drug effects; Proto-Oncogene Proteins c-myc - biosynthesis; RNA, Messenger - biosynthesis; RNA, Neoplasm - biosynthesis; Rodents; Studies; Tumor; Tumor Cells, Cultured - drug effects; Tumor Cells, Cultured - metabolism; Tumor Cells, Cultured - transplantation; Tumors; Xenograft; Xenograft Model Antitumor Assays; Japan; Tumor; Xenograft; c-myc; FK228; p21