Determinants of Per-Coital-Act HIV-1 Infectivity Among African HIV-1-Serodiscordant Couples

• Published in: The Journal of infectious diseases Vol. 205; no. 3; pp. 358 - 365
• Main Authors: Hughes, James P., Baeten, Jared M., Lingappa, Jairam R., Mageret, Amalia S., Wald, Anna, de Bruyn, Guy, Kiarie, James, Inambao, Mubiana, Kilembe, William, Farquhar, Carey, Celum, Connie
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.02.2012
• Series: Editor's Choice
• Subjects: Adult; Africa; Biological and medical sciences; Condoms; Condoms - utilization; Disease transmission; Family Characteristics; Female; Fundamental and applied biological sciences. Psychology; Genotype; Herpes simplex virus 2; HIV; HIV 1; HIV Infections - transmission; HIV Infections - virology; HIV-1 - classification; HIV-1 - genetics; HIV-1 - isolation & purification; HIV/AIDS; Human herpesvirus 2; Human immunodeficiency virus 1; Humans; Infections; Infectious diseases; Major and Brief Reports; Male; Medical sciences; Microbiology; Miscellaneous; Prospective Studies; Research universities; Risk Assessment; RNA; RNA, Viral - genetics; Sexual Behavior - statistics & numerical data; Sexual transmission; Trichomonas vaginalis; Vaginitis; Viral Load; Virology; Africa; Virus; Infection; HIV-1 virus; Infectivity; Retroviridae; Human immunodeficiency virus; Lentivirus

Background. Knowledge of factors that affect per-act infectivity of human immunodeficiency virus type 1 (HIV-1) is important for designing HIV-1 prevention interventions and for the mathematical modeling of the spread of HIV-1. Methods. We analyzed data from a prospective study of African HIV-1-sero...