Sulforaphane attenuates the development of atherosclerosis and improves endothelial dysfunction in hypercholesterolemic rabbits
The aim of the present work was to explore possible protective effects of sulforaphane (SFN) against atherosclerosis development and endothelial dysfunction in hypercholesterolemic rabbits. Rabbits were assigned to three groups of five: group I fed normal chow diet for four weeks, group II fed 1% hi...
Saved in:
Published in | Experimental biology and medicine (Maywood, N.J.) Vol. 241; no. 4; pp. 426 - 436 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
London, England
SAGE Publications
01.02.2016
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The aim of the present work was to explore possible protective effects of sulforaphane (SFN) against atherosclerosis development and endothelial dysfunction in hypercholesterolemic rabbits. Rabbits were assigned to three groups of five: group I fed normal chow diet for four weeks, group II fed 1% high cholesterol diet (HCD) and group III fed HCD + SFN (0.25 mg/kg/day). Blood samples were collected for measurement of serum triglycerides (TGs), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), lactate dehydrogenase (LDH) and C-reactive protein (CRP). Aortic malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and total nitrite/nitrate (NOx) were measured. Vascular reactivity and intima/media (I/M) ratio were analyzed. Nuclear factor-kappa B (NF-κB) activation in aortic endothelial cells was identified immunohistochemically. HCD induced significant increases in serum TGs, TC, LDL-C, LDH, and CRP, and aortic MDA and SOD. Moreover, HCD caused significant reductions in serum HDL-C, aortic GSH and NOx. SFN administration significantly decreased HCD-induced elevations in serum TC, LDL-C, CRP, and LDH. while significantly increased HDL-C and GSH levels and normalized aortic SOD and NOx. Additionally, SFN significantly improved rabbit aortic endothelium-dependent relaxation to acetylcholine. Moreover, SFN significantly reduced the elevation in I/M ratio. This effect was confirmed by aortic histopathologic examination. The expression of NF-κB in aortic tissue showed a marked reduction upon treatment with SFN. In conclusion, this study reveals that SFN has the ability to ameliorate HCD-induced atherosclerotic lesions progression and vascular dysfunction, possibly via its lipid-lowering and antioxidant effects and suppression of NF-κB-mediated inflammation. |
---|---|
AbstractList | The aim of the present work was to explore possible protective effects of sulforaphane (SFN) against atherosclerosis development and endothelial dysfunction in hypercholesterolemic rabbits. Rabbits were assigned to three groups of five: group I fed normal chow diet for four weeks, group II fed 1% high cholesterol diet (HCD) and group III fed HCD + SFN (0.25 mg/kg/day). Blood samples were collected for measurement of serum triglycerides (TGs), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), lactate dehydrogenase (LDH) and C-reactive protein (CRP). Aortic malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and total nitrite/nitrate (NOx) were measured. Vascular reactivity and intima/media (I/M) ratio were analyzed. Nuclear factor-kappa B (NF-κB) activation in aortic endothelial cells was identified immunohistochemically. HCD induced significant increases in serum TGs, TC, LDL-C, LDH, and CRP, and aortic MDA and SOD. Moreover, HCD caused significant reductions in serum HDL-C, aortic GSH and NOx. SFN administration significantly decreased HCD-induced elevations in serum TC, LDL-C, CRP, and LDH. while significantly increased HDL-C and GSH levels and normalized aortic SOD and NOx. Additionally, SFN significantly improved rabbit aortic endothelium-dependent relaxation to acetylcholine. Moreover, SFN significantly reduced the elevation in I/M ratio. This effect was confirmed by aortic histopathologic examination. The expression of NF-κB in aortic tissue showed a marked reduction upon treatment with SFN. In conclusion, this study reveals that SFN has the ability to ameliorate HCD-induced atherosclerotic lesions progression and vascular dysfunction, possibly via its lipid-lowering and antioxidant effects and suppression of NF-κB-mediated inflammation. |
Author | Shehatou, George SG Suddek, Ghada M |
AuthorAffiliation | Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt |
AuthorAffiliation_xml | – name: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt |
Author_xml | – sequence: 1 givenname: George SG surname: Shehatou fullname: Shehatou, George SG email: georgeshehatou@gmail.com – sequence: 2 givenname: Ghada M surname: Suddek fullname: Suddek, Ghada M |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26490346$$D View this record in MEDLINE/PubMed |
BookMark | eNp1UUtLxDAQDqL4vnuS_IFqkjbN5iKI-ALBg3ouaTq1kTQpSbqwJ_-6WVZFBS-TId9j-GYO0LbzDhA6oeSMUiHOKS95KQijvCaylnwL7a-_irKWcvurz_geOojxjRDKBat30R6rK0nKqt5H70-z7X1Q06AcYJUSuFkliDgNgDtYgvXTCC5h32d0gOCjtutqIlauw2acgl9mPrjOZ9waZXG3iv3sdDLeYePwsJog6MFbiClLLYxG46Da1qR4hHZ6ZSMcf76H6OXm-vnqrnh4vL2_unwoNBckFQvZE8IZzRGIZgtZCdaznkrGF1VFOiEqTRUI1lJJugWtWyBClDWXquxaBrI8RBcb32luR-h0jhSUbaZgRhVWjVem-Y04MzSvftlUsuQVFdmAbAx0Dh8D9N9aSpr1MZq_x8iS058zvwVf28-EYkOI6hWaNz8Hl3fwv-EHmoCX1g |
CitedBy_id | crossref_primary_10_1016_j_biopha_2024_117056 crossref_primary_10_1016_j_lfs_2022_120780 crossref_primary_10_1016_j_pharmthera_2022_108152 crossref_primary_10_3390_nu13072143 crossref_primary_10_9758_cpn_2021_19_3_470 crossref_primary_10_1161_CIRCRESAHA_122_321837 crossref_primary_10_1177_0960327119893414 crossref_primary_10_1016_j_jtcme_2022_08_002 crossref_primary_10_1038_s41598_022_12347_6 crossref_primary_10_1186_s12950_023_00330_5 crossref_primary_10_3390_nu15092117 crossref_primary_10_2139_ssrn_3975295 crossref_primary_10_1007_s00284_016_1079_8 crossref_primary_10_2174_0929867327666200505084620 crossref_primary_10_1016_j_redox_2019_101271 crossref_primary_10_1007_s00210_018_1547_8 crossref_primary_10_1007_s11357_019_00107_w crossref_primary_10_2147_DDDT_S218357 crossref_primary_10_1016_j_clnesp_2018_12_087 crossref_primary_10_1016_j_atherosclerosis_2024_117615 crossref_primary_10_1016_j_phrs_2020_105125 crossref_primary_10_1007_s00044_020_02687_1 crossref_primary_10_1007_s10787_022_01044_5 crossref_primary_10_1016_j_placenta_2023_08_063 crossref_primary_10_1016_j_lfs_2023_121664 crossref_primary_10_3390_molecules27175422 crossref_primary_10_1080_15384101_2021_2015669 crossref_primary_10_1080_21655979_2022_2030592 crossref_primary_10_3390_biomedicines12061169 crossref_primary_10_1002_cti2_1016 crossref_primary_10_1016_j_preghy_2019_02_002 crossref_primary_10_1089_ars_2019_7888 crossref_primary_10_1093_cvr_cvad076 crossref_primary_10_1038_s41598_021_87367_9 crossref_primary_10_1016_j_etap_2018_12_008 crossref_primary_10_1016_j_tips_2019_02_004 crossref_primary_10_3389_fcimb_2020_586923 crossref_primary_10_3390_molecules27030624 crossref_primary_10_3389_fphar_2021_767975 crossref_primary_10_1016_j_bmcl_2018_01_009 crossref_primary_10_1016_j_jare_2020_05_015 crossref_primary_10_3892_mmr_2017_8235 |
Cites_doi | 10.1161/01.RES.77.3.510 10.1161/01.CIR.103.21.2531 10.1093/jn/126.suppl_4.1067S 10.1161/01.RES.80.6.894 10.1056/NEJM196701052760107 10.1074/jbc.M802800200 10.1016/j.atherosclerosis.2012.07.040 10.1016/S0076-6879(96)68016-1 10.1097/00002371-199301000-00001 10.1016/j.ijcard.2015.07.014 10.1093/cvr/21.1.34 10.1111/j.1749-6632.2011.06092.x 10.1016/j.atherosclerosis.2010.07.015 10.1016/0027-5107(85)90216-7 10.1016/j.vph.2011.11.007 10.1093/clinchem/24.6.931 10.1073/pnas.0402004101 10.1016/0002-8703(93)90102-F 10.1016/0002-9378(88)90189-5 10.1172/JCI115499 10.1016/S0021-9258(18)54242-3 10.1002/iub.587 10.1016/0003-2697(79)90738-3 10.1074/jbc.270.2.933 10.1016/0891-5849(88)90111-6 10.1074/jbc.M109.009175 10.1089/ars.2008.2248 10.1161/01.CIR.94.3.498 10.1093/clinchem/18.6.499 10.1017/S0007114507824093 10.1038/sj.bjp.0703127 10.1155/2014/123963 10.1016/0024-3205(95)02315-1 10.1016/S0278-6915(99)00082-4 10.1016/S1054-8807(04)00004-3 10.2337/db06-1003 10.1016/0021-9150(93)90110-G 10.1073/pnas.94.19.10367 10.1074/jbc.M300931200 10.1016/0891-5849(88)90071-8 10.1016/j.clnu.2004.01.006 10.1016/0003-9861(59)90090-6 10.1016/0891-5849(88)90070-6 10.1007/s12012-008-9020-4 10.1161/01.ATV.20.9.2094 10.1016/j.vph.2007.11.006 10.1161/01.RES.82.12.1298 10.1093/oxfordjournals.aje.a009738 10.3945/ajcn.110.009340 10.1016/S1388-1981(00)00027-5 10.1016/j.jnutbio.2014.03.011 10.1016/j.ab.2005.09.040 10.1056/NEJM198904063201407 10.1111/j.1582-4934.2011.01367.x 10.1074/jbc.275.17.12633 10.1074/jbc.M312198200 10.1016/j.clnu.2008.10.011 10.1073/pnas.93.16.8745 10.1016/j.amjcard.2008.02.012 10.1172/JCI116491 10.1002/mnfr.201300063 10.1152/ajpheart.2001.281.1.H75 10.1093/clinchem/20.4.470 10.1007/s00011-009-0017-7 10.1016/0021-9150(90)90019-F 10.1002/ijc.21191 10.1093/clinchem/41.6.904 10.1177/107424849700200409 10.1016/j.pathophys.2006.05.002 10.1161/01.ATV.21.1.122 10.1111/jphp.12204 |
ContentType | Journal Article |
Copyright | 2016 by the Society for Experimental Biology and Medicine 2016 by the Society for Experimental Biology and Medicine. 2016 by the Society for Experimental Biology and Medicine 2016 The Society for Experimental Biology and Medicine |
Copyright_xml | – notice: 2016 by the Society for Experimental Biology and Medicine – notice: 2016 by the Society for Experimental Biology and Medicine. – notice: 2016 by the Society for Experimental Biology and Medicine 2016 The Society for Experimental Biology and Medicine |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 5PM |
DOI | 10.1177/1535370215609695 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef |
DatabaseTitleList | MEDLINE CrossRef |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Anatomy & Physiology Biology |
EISSN | 1535-3699 |
EndPage | 436 |
ExternalDocumentID | 10_1177_1535370215609695 26490346 10.1177_1535370215609695 |
Genre | Journal Article |
GroupedDBID | --- -MK -~X .55 .GJ 0R~ 2WC 35A 3O- 4.4 53G 5GY 5I- 5I. 9T4 AACMV AACTG AAGMC AATBZ AAUAS AAXGE ABJNI ABWRX ACARO ACFEJ ACFIC ACGFS ACGZU ACNCT ACPTO ACSBE ACUAV ADBBV ADFPL ADWAY AECGH AEMJX AENEX AEPTA AEWDL AEWLI AFIEG AFKRG AFNTS AFOSN AGCDD AHOKE AI. AIIQI AIOMO AJUZI ALMA_UNASSIGNED_HOLDINGS AMCVQ AOIJS ARTOV AYAKG BKIIM BPACV C1A C45 CS3 DB0 DC. DF0 DO- DU5 EBS EJD EMOBN F5P GROUPED_DOAJ HYE HZ~ H~9 J8X L7B M4V MV1 MVM O9- OK1 OVD P.B P.C RPM RSE SCNPE SFC SPV TRM UPT VH1 W8F WOQ X7M XOL YKV ZCA ZGI ~KM CGR CUY CVF ECM EIF H13 NPM AAYXX CITATION 5PM |
ID | FETCH-LOGICAL-c570t-89f005210010c289472f2f19258440d774c1ae72b190d816be0773659a3db2e93 |
IEDL.DBID | RPM |
ISSN | 1535-3702 |
IngestDate | Tue Sep 17 21:20:00 EDT 2024 Thu Sep 26 16:03:57 EDT 2024 Sat Sep 28 08:35:16 EDT 2024 Tue Jul 16 20:53:44 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 4 |
Keywords | NF-κB sulforaphane nitric oxide Hypercholesterolemia lipid profile endothelial dysfunction oxidative stress |
Language | English |
License | 2016 by the Society for Experimental Biology and Medicine. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c570t-89f005210010c289472f2f19258440d774c1ae72b190d816be0773659a3db2e93 |
OpenAccessLink | https://europepmc.org/articles/pmc4935417?pdf=render |
PMID | 26490346 |
PageCount | 11 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4935417 crossref_primary_10_1177_1535370215609695 pubmed_primary_26490346 sage_journals_10_1177_1535370215609695 |
PublicationCentury | 2000 |
PublicationDate | 2016-02-01 |
PublicationDateYYYYMMDD | 2016-02-01 |
PublicationDate_xml | – month: 02 year: 2016 text: 2016-02-01 day: 01 |
PublicationDecade | 2010 |
PublicationPlace | London, England |
PublicationPlace_xml | – name: London, England – name: England – name: Sage UK: London, England |
PublicationTitle | Experimental biology and medicine (Maywood, N.J.) |
PublicationTitleAlternate | Exp Biol Med (Maywood) |
PublicationYear | 2016 |
Publisher | SAGE Publications |
Publisher_xml | – name: SAGE Publications |
References | McMahon, Itoh, Yamamoto, Hayes 2003; 278 Ohkawa, Ohishi, Yagi 1979; 95 Yoxall, Kentish, Coldham, Kuhnert, Sauer, Ioannides 2005; 117 De La Cruz, Quintero, Villalobos, Sanchez de la Cuesta 2000; 1485 White, Darley-Usmar, Berrington, McAdams, Gore, Thompson, Parks, Tarpey, Freeman 1996; 93 Fahey, Talalay 1999; 37 Raghavamenon, Garelnabi, Babu, Aldrich, Litvinov, Parthasarathy 2009; 1.48–1 Ma, Lopez, Liu, Christopher, Gao, Guo, Feuerstein, Ruffolo, Barone, Yue 1997; 80 Finley, Schifman, Williams, Lichti 1978; 24 Schrader, Graeser, Huebbe, Wagner, Rimbach 2012; 64 Torzewski, Rist, Mortensen, Zwaka, Bienek, Waltenberger, Koenig, Schmitz, Hombach, Torzewski 2000; 20 Huang, Lin, Liu, Tsai, Chang, Chen, Lii 2013; 57 Chappell, Lewis, Henderson 1987; 21 Miller, Gutterman, Rios, Heistad, Davidson 1998; 82 Jeremy, McCarron, Sullivan 1996; 94 Mantha, Kalra, Prasad 1996; 58 Aikawa, Libby 2004; 13 Hanlon, Coldham, Gielbert, Kuhnert, Sauer, King, Ioannides 2008; 99 Dinkova-Kostova, Talalay 2008; 52 Kivela, Makinen, Jyrkkanen, Mella-Aho, Xia, Kansanen, Leinonen, Verma, Yla-Herttuala, Levonen 2010; 213 Allain, Poon, Chan, Richmond, Fu 1974; 20 Del Boccio, Lapenna, Porreca, Pennelli, Savini, Feliciani, Ricci, Cuccurullo 1990; 81 Hassan 1988; 5 Kwon, Joung, Kim, Shim, Ahn, Jeong, Kee 2012; 225 Hennig, Chow 1988; 4 Bories, Bories 1995; 41 Prasad, Mantha, Kalra, Lee 1997; 2 Wagner, Boesch-Saadatmandi, Dose, Schultheiss, Rimbach 2012; 16 Granger, Taintor, Boockvar, Hibbs 1996; 268 Boyle, Kovacich, Canty, Morgan, Chi, Verrier, Pohlman 1998; 98 Zhang, Shu, Xiang, Yang, Li, Gao, Cai, Gao, Zheng 2011; 94 Xue, Qian, Adaikalakoteswari, Rabbani, Babaei-Jadidi, Thornalley 2008; 57 Fredrickson, Levy, Lees 1967; 276 El-Awady, Suddek 2014; 66 Katsiki, Manes 2009; 28 Wilson, Simari, Best, Peterson, Lerman, Aviram, Nath, Holmes, Lerman 2001; 21 Nallasamy, Si, Babu, Pan, Fu, Brooke, Shah, Zhen, Zhu, Liu, Li, Jia 2014; 25 Cominacini, Pasini, Garbin, Davoli, Tosetti, Campagnola, Rigoni, Pastorino, Lo Cascio, Sawamura 2000; 275 Duell 1996; 126 Ellman 1959; 82 Friedewald, Levy, Fredrickson 1972; 18 Fahey, Zhang, Talalay 1997; 94 Liu, Hsieh, Weng, Chuang, Hsieh, Wung 2008; 48 Ledebur, Parks 1995; 270 Castelli 1988; 158 Wu, Noyan Ashraf, Facci, Wang, Paterson, Ferrie, Juurlink 2004; 101 Steinberg, Parthasarathy, Carew, Khoo, Witztum 1989; 320 Kim, Park, Um, Sohn, Kim, Moon, Rhee, Pyo 2012; 56 Prasad, Kalra 1993; 125 Pritchard, Groszek, Smalley, Sessa, Wu, Villalon, Wolin, Stemerman 1995; 77 Yochum, Kushi, Meyer, Folsom 1999; 149 Witztum, Steinberg 1991; 88 Adachi, Cohen 2000; 129 Thomassen, Meeker, Deodhar, Wiedemann, Barna 1993; 13 Ohara, Peterson, Harrison 1993; 91 Mantha, Prasad, Kalra, Prasad 1993; 101 Wu, Shrestha, Ong, Johns, Dunn, Hou, Barter, Rye 2015; 199 Heiss, Schachner, Werner, Dirsch 2009; 284 Marklund 1985; 148 Pasceri, Cheng, Willerson, Yeh 2001; 103 Keum 2011; 1229 Thimmulappa, Mai, Srisuma, Kensler, Yamamoto, Biswal 2002; 62 Li, Reddy, Miao, Shanmugam, Yee, Hawkins, Ren, Natarajan 2008; 283 Prasad 1999; 9 Zhu, Jia, Strobl, Ehrich, Misra, Li 2008; 8 Chen, Dodd, Kunsch 2009; 58 Yeh, Gharavi, Choi, Hsieh, Reed, Mouillesseaux, Cole, Reddy, Berliner 2004; 279 Wang, Zhang, Sun, Tan, Liu, Zheng, Liu, Cai, Sun 2014; 2014 Shull, Heintz, Periasamy, Manohar, Janssen, Marsh, Mossman 1991; 266 Song, Morrison, Botting, Thornalley 2005; 347 Rubanyi 1988; 4 Singh, Jialal 2006; 13 Willcox, Curb, Rodriguez 2008; 101 Jeon, Park, Choi 2004; 34–23 Thakur, Hayashi, Sumi, Kano, Tsunekawa, Iguchi 2001; 281 bibr2-1535370215609695 bibr32-1535370215609695 bibr75-1535370215609695 bibr24-1535370215609695 bibr15-1535370215609695 bibr67-1535370215609695 Thimmulappa RK (bibr14-1535370215609695) 2002; 62 bibr58-1535370215609695 bibr41-1535370215609695 bibr25-1535370215609695 bibr50-1535370215609695 bibr68-1535370215609695 bibr3-1535370215609695 Prasad K (bibr21-1535370215609695) 1999; 9 bibr33-1535370215609695 bibr16-1535370215609695 bibr42-1535370215609695 Dinkova-Kostova AT (bibr9-1535370215609695) 2008; 52 bibr18-1535370215609695 bibr34-1535370215609695 bibr47-1535370215609695 bibr60-1535370215609695 bibr65-1535370215609695 bibr39-1535370215609695 bibr73-1535370215609695 bibr26-1535370215609695 bibr13-1535370215609695 bibr44-1535370215609695 bibr31-1535370215609695 bibr52-1535370215609695 bibr36-1535370215609695 bibr49-1535370215609695 bibr10-1535370215609695 bibr5-1535370215609695 bibr23-1535370215609695 bibr57-1535370215609695 Boyle EM (bibr59-1535370215609695) 1998; 98 bibr70-1535370215609695 bibr37-1535370215609695 bibr45-1535370215609695 bibr62-1535370215609695 bibr54-1535370215609695 bibr6-1535370215609695 bibr11-1535370215609695 bibr71-1535370215609695 bibr8-1535370215609695 bibr28-1535370215609695 bibr63-1535370215609695 bibr38-1535370215609695 bibr20-1535370215609695 bibr46-1535370215609695 bibr72-1535370215609695 bibr29-1535370215609695 bibr55-1535370215609695 bibr12-1535370215609695 bibr7-1535370215609695 bibr69-1535370215609695 bibr51-1535370215609695 bibr48-1535370215609695 bibr64-1535370215609695 bibr35-1535370215609695 bibr22-1535370215609695 bibr4-1535370215609695 bibr30-1535370215609695 bibr17-1535370215609695 bibr43-1535370215609695 bibr56-1535370215609695 bibr19-1535370215609695 bibr74-1535370215609695 bibr1-1535370215609695 bibr61-1535370215609695 bibr66-1535370215609695 bibr53-1535370215609695 bibr40-1535370215609695 bibr27-1535370215609695 |
References_xml | – volume: 98 start-page: II282 year: 1998 end-page: 8 article-title: Inhibition of nuclear factor-kappa B nuclear localization reduces human E-selectin expression and the systemic inflammatory response publication-title: Circulation contributor: fullname: Pohlman – volume: 268 start-page: 142 year: 1996 end-page: 51 article-title: Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction publication-title: Meth Enzymol contributor: fullname: Hibbs – volume: 25 start-page: 824 year: 2014 end-page: 33 article-title: Sulforaphane reduces vascular inflammation in mice and prevents TNF-alpha-induced monocyte adhesion to primary endothelial cells through interfering with the NF-kappaB pathway publication-title: J Nutr Biochem contributor: fullname: Jia – volume: 101 start-page: 75D year: 2008 end-page: 86D article-title: Antioxidants in cardiovascular health and disease: key lessons from epidemiologic studies publication-title: Am J Cardiol contributor: fullname: Rodriguez – volume: 266 start-page: 24398 year: 1991 end-page: 403 article-title: Differential regulation of antioxidant enzymes in response to oxidants publication-title: J Biol Chem contributor: fullname: Mossman – volume: 279 start-page: 30175 year: 2004 end-page: 81 article-title: Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway publication-title: J Biol Chem contributor: fullname: Berliner – volume: 18 start-page: 499 year: 1972 end-page: 502 article-title: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge publication-title: Clin Chem contributor: fullname: Fredrickson – volume: 82 start-page: 1298 year: 1998 end-page: 305 article-title: Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis publication-title: Circ Res contributor: fullname: Davidson – volume: 88 start-page: 1785 year: 1991 end-page: 92 article-title: Role of oxidized low density lipoprotein in atherogenesis publication-title: J Clin Invest contributor: fullname: Steinberg – volume: 126 start-page: 1067S year: 1996 end-page: 71S article-title: Prevention of atherosclerosis with dietary antioxidants: fact or fiction? publication-title: J Nutr contributor: fullname: Duell – volume: 24 start-page: 931 year: 1978 end-page: 3 article-title: Cholesterol in high-density lipoprotein: use of Mg2+/dextran sulfate in its enzymic measurement publication-title: Clin Chem contributor: fullname: Lichti – volume: 117 start-page: 356 year: 2005 end-page: 62 article-title: Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity publication-title: Int J Cancer contributor: fullname: Ioannides – volume: 82 start-page: 70 year: 1959 end-page: 7 article-title: Tissue sulfhydryl groups publication-title: Arch Biochem Biophys contributor: fullname: Ellman – volume: 91 start-page: 2546 year: 1993 end-page: 51 article-title: Hypercholesterolemia increases endothelial superoxide anion production publication-title: J Clin Invest contributor: fullname: Harrison – volume: 41 start-page: 904 year: 1995 end-page: 7 article-title: Nitrate determination in biological fluids by an enzymatic one-step assay with nitrate reductase publication-title: Clin Chem contributor: fullname: Bories – volume: 77 start-page: 510 year: 1995 end-page: 8 article-title: Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion publication-title: Circ Res contributor: fullname: Stemerman – volume: 276 start-page: 34 year: 1967 end-page: 42 article-title: Fat transport in lipoproteins – an integrated approach to mechanisms and disorders publication-title: N Engl J Med contributor: fullname: Lees – volume: 58 start-page: 503 year: 1996 end-page: 9 article-title: Effects of probucol on hypercholesterolemia-induced changes in antioxidant enzymes publication-title: Life Sci contributor: fullname: Prasad – volume: 21 start-page: 122 year: 2001 end-page: 8 article-title: Simvastatin preserves coronary endothelial function in hypercholesterolemia in the absence of lipid lowering publication-title: Arterioscler Thromb Vasc Biol contributor: fullname: Lerman – volume: 284 start-page: 31579 year: 2009 end-page: 86 article-title: Active NF-E2-related factor (Nrf2) contributes to keep endothelial NO synthase (eNOS) in the coupled state: role of reactive oxygen species (ROS), eNOS, and heme oxygenase (HO-1) levels publication-title: J Biol Chem contributor: fullname: Dirsch – volume: 99 start-page: 559 year: 2008 end-page: 64 article-title: Absolute bioavailability and dose-dependent pharmacokinetic behaviour of dietary doses of the chemopreventive isothiocyanate sulforaphane in rat publication-title: Br J Nutr contributor: fullname: Ioannides – volume: 4 start-page: 99 year: 1988 end-page: 106 article-title: Lipid peroxidation and endothelial cell injury: implications in atherosclerosis publication-title: Free Radic Biol Med contributor: fullname: Chow – volume: 8 start-page: 115 year: 2008 end-page: 25 article-title: Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous sulforaphane in rat aortic smooth muscle cells: cytoprotection against oxidative and electrophilic stress publication-title: Cardiovasc Toxicol contributor: fullname: Li – volume: 57 start-page: 2809 year: 2008 end-page: 17 article-title: Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease publication-title: Diabetes contributor: fullname: Thornalley – volume: 16 start-page: 836 year: 2012 end-page: 43 article-title: Anti-inflammatory potential of allyl-isothiocyanate–role of Nrf2, NF-(kappa) B and microRNA-155 publication-title: J Cell Mol Med contributor: fullname: Rimbach – volume: 48 start-page: 54 year: 2008 end-page: 61 article-title: Sulforaphane inhibition of monocyte adhesion via the suppression of ICAM-1 and NF-kappaB is dependent upon glutathione depletion in endothelial cells publication-title: Vasc Pharmacol contributor: fullname: Wung – volume: 225 start-page: 41 year: 2012 end-page: 9 article-title: Sulforaphane inhibits restenosis by suppressing inflammation and the proliferation of vascular smooth muscle cells publication-title: Atherosclerosis contributor: fullname: Kee – volume: 158 start-page: 1553 year: 1988 end-page: 60, 66–7 article-title: Cardiovascular disease in women publication-title: Am J Obstet Gynecol contributor: fullname: Castelli – volume: 52 start-page: S128 year: 2008 end-page: 38. article-title: Direct and indirect antioxidant properties of inducers of cytoprotective proteins publication-title: Mol Nutr Food Res contributor: fullname: Talalay – volume: 13 start-page: 125 year: 2004 end-page: 38 article-title: The vulnerable atherosclerotic plaque: pathogenesis and therapeutic approach publication-title: Cardiovasc Pathol contributor: fullname: Libby – volume: 13 start-page: 1 year: 1993 end-page: 6 article-title: Activation of human monocytes and alveolar macrophages by a synthetic peptide of C-reactive protein publication-title: J Immunother Emphasis Tumor Immunol contributor: fullname: Barna – volume: 94 start-page: 10367 year: 1997 end-page: 72 article-title: Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens publication-title: Proc Natl Acad Sci U S A contributor: fullname: Talalay – volume: 2014 start-page: 123963 year: 2014 end-page: 123963 article-title: Sulforaphane attenuation of type 2 diabetes-induced aortic damage was associated with the upregulation of Nrf2 expression and function publication-title: Oxid Med Cell Longev contributor: fullname: Sun – volume: 149 start-page: 943 year: 1999 end-page: 9 article-title: Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women publication-title: Am J Epidemiol contributor: fullname: Folsom – volume: 5 start-page: 377 year: 1988 end-page: 85 article-title: Biosynthesis and regulation of superoxide dismutases publication-title: Free Radic Biol Med contributor: fullname: Hassan – volume: 270 start-page: 933 year: 1995 end-page: 43 article-title: Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. Essential roles of a variant NF-kappa B site and p65 homodimers publication-title: J Biol Chem contributor: fullname: Parks – volume: 57 start-page: 1918 year: 2013 end-page: 30 article-title: Isothiocyanates protect against ox idized LDL-induced endothelial dysfunction by upregulating Nrf2-dependent antioxidation and suppressing NFkappaB activation publication-title: Mol Nutr Food Res contributor: fullname: Lii – volume: 9 start-page: 9.62 year: 1999 end-page: 1355 article-title: Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed publication-title: Circulation contributor: fullname: Prasad – volume: 28 start-page: 3 year: 2009 end-page: 9 article-title: Is there a role for supplemented antioxidants in the prevention of atherosclerosis? publication-title: Clin Nutr contributor: fullname: Manes – volume: 20 start-page: 2094 year: 2000 end-page: 9 article-title: C-reactive protein in the arterial intima: role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis publication-title: Arterioscler Thromb Vasc Biol contributor: fullname: Torzewski – volume: 95 start-page: 351 year: 1979 end-page: 8 article-title: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction publication-title: Anal Biochem contributor: fullname: Yagi – volume: 281 start-page: H75 year: 2001 end-page: 83 article-title: HMG-CoA reductase inhibitor stabilizes rabbit atheroma by increasing basal NO and decreasing superoxide publication-title: Am J Physiol Heart Circ Physiol contributor: fullname: Iguchi – volume: 56 start-page: 131 year: 2012 end-page: 41 article-title: Sulforaphane suppresses vascular adhesion molecule-1 expression in TNF-alpha-stimulated mouse vascular smooth muscle cells: involvement of the MAPK, NF-kappaB and AP-1 signaling pathways publication-title: Vasc Pharmacol contributor: fullname: Pyo – volume: 213 start-page: 122 year: 2010 end-page: 8 article-title: Sulforaphane inhibits endothelial lipase expression through NF-kappaB in endothelial cells publication-title: Atherosclerosis contributor: fullname: Levonen – volume: 81 start-page: 127 year: 1990 end-page: 35 article-title: Aortic antioxidant defence mechanisms: time-related changes in cholesterol-fed rabbits publication-title: Atherosclerosis contributor: fullname: Cuccurullo – volume: 80 start-page: 894 year: 1997 end-page: 90 article-title: Hypercholesterolemia impairs a detoxification mechanism against peroxynitrite and renders the vascular tissue more susceptible to oxidative injury publication-title: Circ Res contributor: fullname: Yue – volume: 1.48–1 start-page: 1237 year: 2009 end-page: 1237 article-title: Alpha-tocopherol is ineffective in preventing the decomposition of preformed lipid peroxides and may promote the accumulation of toxic aldehydes: a potential explanation for the failure of antioxidants to affect human atherosclerosis publication-title: Antioxid Redox Signal contributor: fullname: Parthasarathy – volume: 37 start-page: 973 year: 1999 end-page: 9 article-title: Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes publication-title: Food Chem Toxicol contributor: fullname: Talalay – volume: 278 start-page: 21592 year: 2003 end-page: 600 article-title: Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression publication-title: J Biol Chem contributor: fullname: Hayes – volume: 347 start-page: 234 year: 2005 end-page: 43 article-title: Analysis of glucosinolates, isothiocyanates, and amine degradation products in vegetable extracts and blood plasma by LC-MS/MS publication-title: Anal Biochem contributor: fullname: Thornalley – volume: 66 start-page: 835 year: 2014 end-page: 43 article-title: Agmatine ameliorates atherosclerosis progression and endothelial dysfunction in high cholesterol-fed rabbits publication-title: J Pharm Pharmacol contributor: fullname: Suddek – volume: 103 start-page: 2531 year: 2001 end-page: 4 article-title: Modulation of C-reactive protein-mediated monocyte chemoattractant protein-1 induction in human endothelial cells by anti-atherosclerosis drugs publication-title: Circulation contributor: fullname: Yeh – volume: 101 start-page: 7094 year: 2004 end-page: 9 article-title: Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system publication-title: Proc Natl Acad Sci U S A contributor: fullname: Juurlink – volume: 21 start-page: 34 year: 1987 end-page: 8 article-title: Effect of lipid feeding on endothelium dependent relaxation in rabbit aortic preparations publication-title: Cardiovasc Res contributor: fullname: Henderson – volume: 34–23 start-page: 1025 year: 2004 end-page: 1025 article-title: Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits publication-title: Clin Nutr contributor: fullname: Choi – volume: 94 start-page: 240 year: 2011 end-page: 6 article-title: Cruciferous vegetable consumption is associated with a reduced risk of total and cardiovascular disease mortality publication-title: Am J Clin Nutr contributor: fullname: Zheng – volume: 320 start-page: 915 year: 1989 end-page: 24 article-title: Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity publication-title: N Engl J Med contributor: fullname: Witztum – volume: 4 start-page: 107 year: 1988 end-page: 20 article-title: Vascular effects of oxygen-derived free radicals publication-title: Free Radic Biol Med contributor: fullname: Rubanyi – volume: 62 start-page: 5196 year: 2002 end-page: 203 article-title: Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray publication-title: Cancer Res contributor: fullname: Biswal – volume: 199 start-page: 204 year: 2015 end-page: 12 article-title: Increasing HDL levels by inhibiting cholesteryl ester transfer protein activity in rabbits with hindlimb ischemia is associated with increased angiogenesis publication-title: Int J Cardiol contributor: fullname: Rye – volume: 129 start-page: 1014 year: 2000 end-page: 20 article-title: Decreased aortic glutathione levels may contribute to impaired nitric oxide-induced relaxation in hypercholesterolaemia publication-title: Br J Pharmacol contributor: fullname: Cohen – volume: 283 start-page: 26771 year: 2008 end-page: 81 article-title: Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation publication-title: J Biol Chem contributor: fullname: Natarajan – volume: 93 start-page: 8745 year: 1996 end-page: 9 article-title: Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits publication-title: Proc Natl Acad Sci U S A contributor: fullname: Freeman – volume: 2 start-page: 309 year: 1997 end-page: 20 article-title: Prevention of hypercholesterolemic atherosclerosis by garlic, an antixoidant publication-title: J Cardiovasc Pharmacol Ther contributor: fullname: Lee – volume: 13 start-page: 129 year: 2006 end-page: 42 article-title: Oxidative stress and atherosclerosis publication-title: Pathophysiology contributor: fullname: Jialal – volume: 275 start-page: 1263 year: 2000 end-page: 83 article-title: Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species publication-title: J Biol Chem contributor: fullname: Sawamura – volume: 58 start-page: 513 year: 2009 end-page: 21 article-title: Sulforaphane inhibits TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells publication-title: Inflamm Res contributor: fullname: Kunsch – volume: 1485 start-page: 36 year: 2000 end-page: 44 article-title: Lipid peroxidation and glutathione system in hyperlipemic rabbits: influence of olive oil administration publication-title: Biochim Biophys Acta contributor: fullname: Sanchez de la Cuesta – volume: 1229 start-page: 184 year: 2011 end-page: 9 article-title: Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications publication-title: Ann N Y Acad Sci contributor: fullname: Keum – volume: 94 start-page: 498 year: 1996 end-page: 506 article-title: Effects of dietary L-arginine on atherosclerosis and endothelium-dependent vasodilatation in the hypercholesterolemic rabbit. Response according to treatment duration, anatomic site, and sex publication-title: Circulation contributor: fullname: Sullivan – volume: 101 start-page: 135 year: 1993 end-page: 44. article-title: Antioxidant enzymes in hypercholesterolemia and effects of vitamin E in rabbits publication-title: Atherosclerosis contributor: fullname: Prasad – volume: 64 start-page: 162 year: 2012 end-page: 8 article-title: Allyl isothiocyanate as a potential inducer of paraoxonase-1–studies in cultured hepatocytes and in mice publication-title: IUBMB Life contributor: fullname: Rimbach – volume: 20 start-page: 470 year: 1974 end-page: 5 article-title: Enzymatic determination of total serum cholesterol publication-title: Clin Chem contributor: fullname: Fu – volume: 148 start-page: 129 year: 1985 end-page: 34 article-title: Superoxide dismutase isoenzymes in tissues and plasma from New Zealand black mice, nude mice and normal BALB/c mice publication-title: Mutat Res contributor: fullname: Marklund – volume: 125 start-page: 958 year: 1993 end-page: 73 article-title: Oxygen free radicals and hypercholesterolemic atherosclerosis: Effect of vitamin E publication-title: Am Heart J contributor: fullname: Kalra – ident: bibr67-1535370215609695 doi: 10.1161/01.RES.77.3.510 – ident: bibr53-1535370215609695 doi: 10.1161/01.CIR.103.21.2531 – ident: bibr5-1535370215609695 doi: 10.1093/jn/126.suppl_4.1067S – ident: bibr31-1535370215609695 doi: 10.1161/01.RES.80.6.894 – ident: bibr19-1535370215609695 doi: 10.1056/NEJM196701052760107 – ident: bibr60-1535370215609695 doi: 10.1074/jbc.M802800200 – ident: bibr28-1535370215609695 doi: 10.1016/j.atherosclerosis.2012.07.040 – ident: bibr25-1535370215609695 doi: 10.1016/S0076-6879(96)68016-1 – ident: bibr54-1535370215609695 doi: 10.1097/00002371-199301000-00001 – ident: bibr51-1535370215609695 doi: 10.1016/j.ijcard.2015.07.014 – ident: bibr64-1535370215609695 doi: 10.1093/cvr/21.1.34 – ident: bibr15-1535370215609695 doi: 10.1111/j.1749-6632.2011.06092.x – ident: bibr49-1535370215609695 doi: 10.1016/j.atherosclerosis.2010.07.015 – ident: bibr24-1535370215609695 doi: 10.1016/0027-5107(85)90216-7 – ident: bibr39-1535370215609695 doi: 10.1016/j.vph.2011.11.007 – ident: bibr18-1535370215609695 doi: 10.1093/clinchem/24.6.931 – ident: bibr10-1535370215609695 doi: 10.1073/pnas.0402004101 – ident: bibr3-1535370215609695 doi: 10.1016/0002-8703(93)90102-F – ident: bibr1-1535370215609695 doi: 10.1016/0002-9378(88)90189-5 – ident: bibr2-1535370215609695 doi: 10.1172/JCI115499 – ident: bibr37-1535370215609695 doi: 10.1016/S0021-9258(18)54242-3 – ident: bibr50-1535370215609695 doi: 10.1002/iub.587 – ident: bibr22-1535370215609695 doi: 10.1016/0003-2697(79)90738-3 – ident: bibr58-1535370215609695 doi: 10.1074/jbc.270.2.933 – ident: bibr38-1535370215609695 doi: 10.1016/0891-5849(88)90111-6 – ident: bibr70-1535370215609695 doi: 10.1074/jbc.M109.009175 – ident: bibr8-1535370215609695 doi: 10.1089/ars.2008.2248 – ident: bibr63-1535370215609695 doi: 10.1161/01.CIR.94.3.498 – ident: bibr20-1535370215609695 doi: 10.1093/clinchem/18.6.499 – ident: bibr73-1535370215609695 doi: 10.1017/S0007114507824093 – volume: 9 start-page: 9.62 year: 1999 ident: bibr21-1535370215609695 publication-title: Circulation contributor: fullname: Prasad K – ident: bibr30-1535370215609695 doi: 10.1038/sj.bjp.0703127 – ident: bibr71-1535370215609695 doi: 10.1155/2014/123963 – ident: bibr4-1535370215609695 doi: 10.1016/0024-3205(95)02315-1 – ident: bibr41-1535370215609695 doi: 10.1016/S0278-6915(99)00082-4 – volume: 52 start-page: S128 year: 2008 ident: bibr9-1535370215609695 publication-title: Mol Nutr Food Res contributor: fullname: Dinkova-Kostova AT – ident: bibr44-1535370215609695 doi: 10.1016/S1054-8807(04)00004-3 – ident: bibr13-1535370215609695 doi: 10.2337/db06-1003 – ident: bibr36-1535370215609695 doi: 10.1016/0021-9150(93)90110-G – ident: bibr72-1535370215609695 doi: 10.1073/pnas.94.19.10367 – ident: bibr16-1535370215609695 doi: 10.1074/jbc.M300931200 – ident: bibr33-1535370215609695 doi: 10.1016/0891-5849(88)90071-8 – ident: bibr42-1535370215609695 doi: 10.1016/j.clnu.2004.01.006 – ident: bibr23-1535370215609695 doi: 10.1016/0003-9861(59)90090-6 – ident: bibr34-1535370215609695 doi: 10.1016/0891-5849(88)90070-6 – ident: bibr40-1535370215609695 doi: 10.1007/s12012-008-9020-4 – ident: bibr55-1535370215609695 doi: 10.1161/01.ATV.20.9.2094 – ident: bibr56-1535370215609695 doi: 10.1016/j.vph.2007.11.006 – ident: bibr69-1535370215609695 doi: 10.1161/01.RES.82.12.1298 – ident: bibr11-1535370215609695 doi: 10.1093/oxfordjournals.aje.a009738 – ident: bibr12-1535370215609695 doi: 10.3945/ajcn.110.009340 – ident: bibr43-1535370215609695 doi: 10.1016/S1388-1981(00)00027-5 – volume: 62 start-page: 5196 year: 2002 ident: bibr14-1535370215609695 publication-title: Cancer Res contributor: fullname: Thimmulappa RK – ident: bibr57-1535370215609695 doi: 10.1016/j.jnutbio.2014.03.011 – ident: bibr75-1535370215609695 doi: 10.1016/j.ab.2005.09.040 – ident: bibr46-1535370215609695 doi: 10.1056/NEJM198904063201407 – ident: bibr61-1535370215609695 doi: 10.1111/j.1582-4934.2011.01367.x – ident: bibr47-1535370215609695 doi: 10.1074/jbc.275.17.12633 – ident: bibr48-1535370215609695 doi: 10.1074/jbc.M312198200 – ident: bibr6-1535370215609695 doi: 10.1016/j.clnu.2008.10.011 – ident: bibr65-1535370215609695 doi: 10.1073/pnas.93.16.8745 – ident: bibr7-1535370215609695 doi: 10.1016/j.amjcard.2008.02.012 – ident: bibr32-1535370215609695 doi: 10.1172/JCI116491 – ident: bibr62-1535370215609695 doi: 10.1002/mnfr.201300063 – ident: bibr68-1535370215609695 doi: 10.1152/ajpheart.2001.281.1.H75 – ident: bibr17-1535370215609695 doi: 10.1093/clinchem/20.4.470 – ident: bibr27-1535370215609695 doi: 10.1007/s00011-009-0017-7 – ident: bibr35-1535370215609695 doi: 10.1016/0021-9150(90)90019-F – volume: 98 start-page: II282 year: 1998 ident: bibr59-1535370215609695 publication-title: Circulation contributor: fullname: Boyle EM – ident: bibr74-1535370215609695 doi: 10.1002/ijc.21191 – ident: bibr26-1535370215609695 doi: 10.1093/clinchem/41.6.904 – ident: bibr29-1535370215609695 doi: 10.1177/107424849700200409 – ident: bibr45-1535370215609695 doi: 10.1016/j.pathophys.2006.05.002 – ident: bibr66-1535370215609695 doi: 10.1161/01.ATV.21.1.122 – ident: bibr52-1535370215609695 doi: 10.1111/jphp.12204 |
SSID | ssj0015726 |
Score | 2.4156427 |
Snippet | The aim of the present work was to explore possible protective effects of sulforaphane (SFN) against atherosclerosis development and endothelial dysfunction in... |
SourceID | pubmedcentral crossref pubmed sage |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 426 |
SubjectTerms | Animals Anticholesteremic Agents - administration & dosage Antioxidants - administration & dosage Aorta - pathology Atherosclerosis - prevention & control C-Reactive Protein - analysis Diet, Atherogenic Histocytochemistry Hypercholesterolemia - complications Immunohistochemistry Isothiocyanates - administration & dosage L-Lactate Dehydrogenase - blood Lipids - blood Male NF-kappa B - analysis Original Research Rabbits Serum - chemistry Tunica Intima - pathology Tunica Media - pathology |
Title | Sulforaphane attenuates the development of atherosclerosis and improves endothelial dysfunction in hypercholesterolemic rabbits |
URI | https://journals.sagepub.com/doi/full/10.1177/1535370215609695 https://www.ncbi.nlm.nih.gov/pubmed/26490346 https://pubmed.ncbi.nlm.nih.gov/PMC4935417 |
Volume | 241 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9tAEB6SQEIvIY-mcdOGPYRAD4r1WGm9xzTUmIBLoQ3kZvYlLLDXxrIPOeWvd2YtOXagl14ss1pYoW9W883uN7MAN1oK1-slRZRpU0Zcx2WkHOeRLAy6W5OYRFLu8PBnMXjij8_58x7kbS5MEO0bXd35yfTOV-OgrZxPTbfViXV_DR-4zHKeiO4-7Issa0P0ZusgF-GMNZzJOc4eku-0e5NdaqMmyh6WhaRTa5APyDgj-rvllja-6L1OckvsFfxP_wSOG-LI7tcPeAp7zp_B-b3HoHn6wm5ZkHKGNfIzOPze_jsaNnvn5_D6ezVBhqrmY-Udo7KafkVEkyEFZPZNO8RmJQu0cFbjQPhb1Ux5y6qw_ID9nbeUtjVBy2X2pSbPSOiyyrMxRrUL-qCG-gt4mVaGLZTW1bL-CE_9H38eBlFz_EJkchEvo54sadGYijTFBuMyLtIyLZERImfhsUXeaBLlRKqRU1iEW7tYiKzIpcqsTp3MLuDAz7y7BOZS2zOxcalTmkurVYrEBBtL7hJbxLYD39q3P5qvq2yMkqYQ-XvQOvBpjcqmZ4thB8QOXpsOVEJ79w5aViil3VhSB24J2VEzf-t_Dv75v4e4gg_ItRrB9xc4WC5W7ivymaW-Dvb7F3fZ87c |
link.rule.ids | 230,315,733,786,790,891,27955,27956,53825,53827 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NT9swFH9ioI1dBoMBHQx8mJB2SJsPJ66PgIa6QdGkwcSt8lfUaK1bNemBXfav79lNOqi0A7skkW3Jid57eb9n_94zwEfJmel2oyxIpMoDKsM8EIbSgGcK3a2KVMRd7nD_Juvd0a_36f0apE0ujCftK1m07WjctsXQcyunY9VpeGKdb_0LypOURqzzAjbQXuO0CdLrzYOU-VPW0JZTtB9H4Gl2JzuuzTW5_GGecXduDSICHiYOAD9yTEtvtMqUfET38h7ocgt-NO--IJ78bM8r2Va_Vso6PvvjtuFNjUnJ2aL7LawZuwO7Zxbj8fEDOSWeJeqX33fg5Xnz9Kpfb8vvwu_v8xGCXzEdCmuIq9hp5w7DEkSXRP-lJZFJTjzinJQ4EV6LkgirSeFXNnC8sdplhI3QKIh-KJ3TdYpDCkuGGDDP3L_al3bA27hQZCakLKryHdxdfr696AX1yQ6BSllYBV2eu_VoV_8pVBjyURbncY5gE-EQDTVCUhUJw2KJcEWjJkkTMpZkKReJlrHhyR6s24k1B0BMrLsqVCY2QlKupYgR82BjTk2ks1C34FMj1sF0UcBjENU1zle1oQX7C3EvRzbK0QL2RBGWA1x17qc9KFdfpbuWYwtOncoM6l9D-c_J3__3FCew2bvtXw-uv9xcHcJrhHQ1r_wI1qvZ3HxA2FTJY28kfwDDlRW9 |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEB6VVlRcoLQUQinsAVXi4Pi19maPpTQqj1SVoFLFJdqXFYtkE8XOoVz4653d2CGN1EsvtrVeaW3NzM43u9_OAHyUnJleL86DVKoioDIqAmEoDXiu0N2qWMXcnR0eXOYX1_TbTXazVurLk_aVLLt2POnacuS5lbOJClueWHg1OKM8zWjMwpkuwiewgzabsDZQbzYQMuYrraE9Z2hDjsTT7lCGrs01uTPEPOeudg2iAh6lDgSvOaeVR9pkS65RvrwX6r-A3-33L8knf7qLWnbV343Ujo_6wT143mBTcrrs8hK2jN2Hg1OLcfnklpwQzxb1y_D78PRz-7Q7aLbnD-Dfz8UYQbCYjYQ1xGXutAuHZQmiTKL_05PItCAeeU4rHAivZUWE1aT0KxzY31jtToaN0TiIvq2c83UKREpLRhg4z92c7VM84G1SKjIXUpZ19Qqu--e_zi6CpsJDoDIW1UGPF25d2uWBihSGfpQlRVIg6ERYRCON0FTFwrBEImzRqFHSRIylecZFqmVieHoI23ZqzRsgJtE9FSmTGCEp11IkiH2wsaAm1nmkO_CpFe1wtkzkMYybXOebGtGB10uRr3q2CtIBdk8ZVh1clu77b1C2Plt3I8sOnDi1GTZTRPXg4G8fPcQH2L360h_--Hr5_QieIbJr6OXvYLueL8wxoqdavvd2cgd_PRg9 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sulforaphane+attenuates+the+development+of+atherosclerosis+and+improves+endothelial+dysfunction+in+hypercholesterolemic+rabbits&rft.jtitle=Experimental+biology+and+medicine+%28Maywood%2C+N.J.%29&rft.au=Shehatou%2C+George+SG&rft.au=Suddek%2C+Ghada+M&rft.date=2016-02-01&rft.issn=1535-3702&rft.eissn=1535-3699&rft.volume=241&rft.issue=4&rft.spage=426&rft.epage=436&rft_id=info:doi/10.1177%2F1535370215609695&rft.externalDBID=n%2Fa&rft.externalDocID=10_1177_1535370215609695 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1535-3702&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1535-3702&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1535-3702&client=summon |