Borna Disease Virus 1 Phosphoprotein Forms a Tetramer and Interacts with Host Factors Involved in DNA Double-Strand Break Repair and mRNA Processing

• Published in: Viruses Vol. 14; no. 11; p. 2358
• Main Authors: Tarbouriech, Nicolas, Chenavier, Florian, Kawasaki, Junna, Bachiri, Kamel, Bourhis, Jean-Marie, Legrand, Pierre, Freslon, Lily L., Laurent, Estelle M. N., Suberbielle, Elsa, Ruigrok, Rob W. H., Tomonaga, Keizo, Gonzalez-Dunia, Daniel, Horie, Masayuki, Coyaud, Etienne, Crépin, Thibaut
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.10.2022; MDPI
• Subjects: Animals; Biochemistry, Molecular Biology; Borna disease; Borna disease virus - genetics; Bornaviridae; Bornaviridae - genetics; Chromatography; Datasets; Development and progression; Disease; DNA; DNA damage; DNA Repair; Double-strand break repair; Epigenetics; Experiments; Gene expression; Genetic aspects; Genomes; Homeostasis; Humans; interactomics; Life Sciences; Mammals; Messenger RNA; Microbiology and Parasitology; mRNA; mRNA processing; phosphoprotein; Phosphoproteins; Phosphoproteins - genetics; Physiological aspects; Polyethylene glycol; Proteins; Replication; RNA polymerase; RNA processing; RNA virus infections; RNA, Messenger - genetics; Sensors; Structural Biology; Structure; Structure-function relationships; Viral proteins; Virology; Virus research; Viruses; Japan; France; phosphoprotein; interactomics; Bornaviridae; structure

Determining the structural organisation of viral replication complexes and unravelling the impact of infection on cellular homeostasis represent important challenges in virology. This may prove particularly useful when confronted with viruses that pose a significant threat to human health, that appe...