Amoxicillin–Clavulanate-Induced Liver Injury

• Published in: Digestive diseases and sciences Vol. 61; no. 8; pp. 2406 - 2416
• Main Authors: deLemos, Andrew S., Ghabril, Marwan, Rockey, Don C., Gu, Jiezhun, Barnhart, Huiman X., Fontana, Robert J., Kleiner, David E., Bonkovsky, Herbert L.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2016; Springer; Springer Nature B.V
• Subjects: Age Factors; Alanine Transaminase - blood; Alkaline Phosphatase - blood; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination - adverse effects; Anti-Bacterial Agents - adverse effects; Anti-infective agents; beta-Lactamase Inhibitors - adverse effects; Bilirubin - blood; Biochemistry; Black or African American; Chemical and Drug Induced Liver Injury - blood; Chemical and Drug Induced Liver Injury - epidemiology; Chemical and Drug Induced Liver Injury - etiology; Chemical and Drug Induced Liver Injury - pathology; Cholestasis - blood; Cholestasis - chemically induced; Cholestasis - epidemiology; Cholestasis - pathology; Clavulanate; Cohort Studies; Ethnicity - statistics & numerical data; Female; Gastroenterology; Hepatology; Hispanic or Latino; Humans; Jaundice; Jaundice, Obstructive - blood; Jaundice, Obstructive - chemically induced; Jaundice, Obstructive - epidemiology; Jaundice, Obstructive - pathology; Liver; Liver - pathology; Male; Medical colleges; Medicine; Medicine & Public Health; Middle Aged; Oncology; Original Article; Pneumoviridae; Prospective Studies; Registries; Sex Distribution; Time Factors; Transplant Surgery; Transplantation of organs, tissues, etc; United States - epidemiology; White People; United States; Augmentin; Allergy; Drug-induced liver injury; Clavulanic acid; Liver toxicity; Amoxicillin

Background and Aims Amoxicillin–clavulanate (AC) is the most frequent cause of idiosyncratic drug-induced injury (DILI) in the US DILI Network (DILIN) registry. Here, we examined a large cohort of AC-DILI cases and compared features of AC-DILI to those of other drugs. Methods Subjects with suspected...