Development of a colorectal cancer diagnostic model and dietary risk assessment through gut microbiome analysis

• Published in: Experimental & molecular medicine Vol. 51; no. 10; pp. 1 - 15
• Main Authors: Yang, Jinho, McDowell, Andrea, Kim, Eun Kyoung, Seo, Hochan, Lee, Won Hee, Moon, Chang-Mo, Kym, Sung-Min, Lee, Dong Ho, Park, Young Soo, Jee, Young-Koo, Kim, Yoon-Keun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.10.2019; Springer Nature B.V; 생화학분자생물학회
• Subjects: 45/23; 692/53/2421; 692/699/67/2322; Aged; Animals; Bacteria - classification; Bacteria - genetics; Biomedical and Life Sciences; Biomedicine; Cancer; Cholesterol; Cholesterol - genetics; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - genetics; Colorectal Neoplasms - microbiology; Colorectal Neoplasms - pathology; Diet; Diet, High-Fat - adverse effects; Dietary intake; Digestive system; Feces - microbiology; Female; Gastrointestinal Microbiome - genetics; Gut microbiota; High cholesterol diet; High fat diet; Humans; Intestinal microflora; Male; Meat; Medical Biochemistry; Metagenome - genetics; Mice; Microbiomes; Microbiota; Microbiota - genetics; Middle Aged; Molecular Medicine; Prediction models; Public health; Risk Assessment; Stem Cells; Westernization; 생화학

Colorectal cancer (CRC) is the third most common form of cancer and poses a critical public health threat due to the global spread of westernized diets high in meat, cholesterol, and fat. Although the link between diet and colorectal cancer has been well established, the mediating role of the gut mi...