Unbiased tensor-based morphometry: Improved robustness and sample size estimates for Alzheimer's disease clinical trials

• Published in: NeuroImage (Orlando, Fla.) Vol. 66; pp. 648 - 661
• Main Authors: Hua, Xue, Hibar, Derrek P., Ching, Christopher R.K., Boyle, Christina P., Rajagopalan, Priya, Gutman, Boris A., Leow, Alex D., Toga, Arthur W., Jack, Clifford R., Harvey, Danielle, Weiner, Michael W., Thompson, Paul M.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.02.2013; Elsevier; Elsevier Limited
• Subjects: ADNI; Adult and adolescent clinical studies; Aged; Aging; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Alzheimer's disease; Apolipoproteins E - genetics; Atrophy; Bias; Biological and medical sciences; Biomarkers; Brain - pathology; Clinical trials; Clinical Trials as Topic; Cognitive Dysfunction - pathology; Data Interpretation, Statistical; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Diffusion Tensor Imaging - instrumentation; Diffusion Tensor Imaging - methods; Discriminant analysis; Drug trial; Estimates; Female; Health care; Humans; Male; Medical imaging; Medical sciences; Methods; Mild cognitive impairment; Neurology; Organic mental disorders. Neuropsychology; Prospective Studies; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Research Design - standards; Software; Tensor-based morphometry; ADNI; VBM; Quarc; AD; MRI; Mild cognitive impairment; BBSI; stat-ROI; Drug trial; SPM; TE; MCI; QC; Tensor-based morphometry; TI; Aging; ApoE; MDT; MI; Alzheimer's disease; FSL; TBM; TR; Nervous system diseases; Senescence; Alzheimer disease; Cerebral disorder; Central nervous system disease; Degenerative disease; mild cognitive impairment; Morphometry

Various neuroimaging measures are being evaluated for tracking Alzheimer's disease (AD) progression in therapeutic trials, including measures of structural brain change based on repeated scanning of patients with magnetic resonance imaging (MRI). Methods to compute brain change must be robust t...