C11orf58 (Hero20) Gene Polymorphism: Contribution to Ischemic Stroke Risk and Interactions with Other Heat-Resistant Obscure Chaperones

• Published in: Biomedicines Vol. 12; no. 11; p. 2603
• Main Authors: Shilenok, Irina, Kobzeva, Ksenia, Soldatov, Vladislav, Deykin, Alexey, Bushueva, Olga
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.11.2024; MDPI
• Subjects: Antihypertensives; Apoptosis; Arteriosclerosis; Atherosclerosis; Brain research; C11orf58; Cell cycle; Cell signaling; Cellular stress response; chaperones; Epidemiology; Ethylenediaminetetraacetic acid; Gene polymorphism; Genes; Genetic aspects; Genetic testing; Genotype & phenotype; heat-resistant obscure; Hero20; Homeostasis; Hypoxia; Ischemia; Lipid metabolism; Mass spectrometry; Medical research; Medicine, Experimental; Molecular modelling; Neurogenesis; Oxidative stress; Physiological aspects; Proteins; Quality control; Risk factors; Scientific imaging; Single nucleotide polymorphisms; Single-nucleotide polymorphism; SNPs; Stroke; Stroke (Disease); Traumatic brain injury; Russia; United States > US; C19orf53; C9orf16; SERBP1; SNPs; Hero20; heat-resistant obscure; C11orf58; chaperones; stroke; SERF2

Background: Recently identified Hero proteins, which possess chaperone-like functions, are promising candidates for research into atherosclerosis-related diseases, including ischemic stroke (IS). Methods: 2204 Russian subjects (917 IS patients and 1287 controls) were genotyped for fifteen common SNP...