Host factors impacting the innate response in humans to the candidate adjuvants RC529 and monophosphoryl lipid A

• Published in: Vaccine Vol. 22; no. 11; pp. 1515 - 1523
• Main Authors: Tiberio, Lorrie, Fletcher, Leah, Eldridge, John H, Duncan, David D
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 29.03.2004; Elsevier; Elsevier Limited
• Subjects: Adjuvant; Adjuvants, Immunologic - pharmacology; Adolescent; Adult; Alleles; Applied microbiology; Biological and medical sciences; Blood; Cytokines; Cytokines - biosynthesis; Cytokines - metabolism; Deoxyribonucleic acid; DNA; DNA - genetics; DNA Primers; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Fundamental and applied biological sciences. Psychology; Genotype; Genotype & phenotype; Genotypes; Humans; Immune system; Kinetics; Lipid A - analogs & derivatives; Lipid A - pharmacology; Lipids; Lipopolysaccharides - pharmacology; Male; Membrane Glycoproteins - genetics; Membrane Glycoproteins - immunology; Microbiology; Middle Aged; Phenotype; Polymorphism, Genetic - genetics; Receptors, Cell Surface - genetics; Receptors, Cell Surface - immunology; Reverse Transcriptase Polymerase Chain Reaction; Sex Characteristics; Signal Transduction - genetics; TLR4; Toll-Like Receptor 4; Toll-Like Receptors; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Genotype; TLR4; Adjuvant; Human; Immunological adjuvant

The aim of this study was to determine if certain genotypes might be associated with variable responses to the candidate vaccine adjuvants RC529 and monophosphoryl lipid A (MPL), as well as to bacterial LPS, a structurally similar control stimulus. In this study, the +896 TLR4 polymorphism and selec...