Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria

• Published in: Journal of allergy and clinical immunology Vol. 134; no. 3; pp. 622 - 633.e9
• Main Authors: Fujisawa, Daisuke, Kashiwakura, Jun-ichi, Kita, Hirohito, Kikukawa, Yusuke, Fujitani, Yasushi, Sasaki-Sakamoto, Tomomi, Kuroda, Kazumichi, Nunomura, Satoshi, Hayama, Koremasa, Terui, Tadashi, Ra, Chisei, Okayama, Yoshimichi
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.2014; Elsevier; Elsevier Limited
• Subjects: Adult; Aged; Aged, 80 and over; Allergic diseases; Allergies; Allergy and Immunology; Biological and medical sciences; Biopsy; Cells, Cultured; Chronic Disease; Chronic urticaria; Cloning; Cytokines; eosinophil granule proteins; Eosinophil Granule Proteins - metabolism; eosinophil peroxidase; eosinophils; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; histamine; human skin mast cells; Humans; Immunopathology; Laboratories; major basic protein; Male; Mas-related gene X2; Mast Cells - immunology; Medical sciences; Middle Aged; Molecular Targeted Therapy; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neuropeptides; Polyclonal antibodies; Protein Binding; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Receptors, Neuropeptide - genetics; Receptors, Neuropeptide - metabolism; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Skin - metabolism; Skin - pathology; Skin allergic diseases. Stinging insect allergies; Skin Tests; substance P; Substance P - administration & dosage; Substance P - adverse effects; Up-Regulation; Urticaria - diagnosis; Urticaria - immunology; Vasoactive Intestinal Peptide - administration & dosage; Vasoactive Intestinal Peptide - adverse effects; Young Adult; United Kingdom > UK; eosinophil peroxidase; histamine; EPO; human skin mast cells; eosinophils; Chronic urticaria; EDN; IMDM; shRNA; MC; MBP; substance P; SP; CB; TSLP; MrgX2; major basic protein; CU; PB; NC; rh; PG; SCF; UAS7; Mas-related gene X2; NK-1R; VIP; eosinophil granule proteins; Stem cell factor; Cord blood; Peripheral blood; Nonatopic control; Prostaglandin; Eosinophil-derived neurotoxin; Small hairpin RNA; Thymic stromal lymphopoietin; Urticaria Activity Score; Recombinant human; Vasoactive intestinal peptide; Mast cell; Iscove modified Dulbecco medium; Neurokinin-1 receptor; Skin disease; Granulocyte; Neuropeptide; Immunology; Gene; Basic protein; Genetics; Peroxidase; Human; Immunopathology; Enzyme; Substance P; Urticaria; Eosinophil; Mass; Histamine; Chronic; Peroxidases; Skin; Oxidoreductases; Tachykinin

Wheal reactions to intradermally injected neuropeptides, such as substance P (SP) and vasoactive intestinal peptide, are significantly larger and longer lasting in patients with chronic urticaria (CU) than in nonatopic control (NC) subjects. Mas-related gene X2 (MrgX2) has been identified as a recep...