The ORF8 protein of SARS-CoV-2 induced endoplasmic reticulum stress and mediated immune evasion by antagonizing production of interferon beta

• Published in: Virus research Vol. 296; p. 198350
• Main Authors: Rashid, Farooq, Dzakah, Emmanuel Enoch, Wang, Haiying, Tang, Shixing
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.04.2021
• Subjects: Activating Transcription Factor 6 - physiology; antagonists; eIF-2 Kinase - physiology; endoplasmic reticulum; Endoplasmic reticulum stress; Endoplasmic Reticulum Stress - physiology; Endoribonucleases - physiology; HEK293 Cells; Humans; Immune Evasion; Interferon beta; interferon regulatory factor-3; Interferon-beta - antagonists & inhibitors; Interferon-beta - biosynthesis; interferons; Open reading frame 8; Open reading frame 8 genotypes; polyinosinic-polycytidylic acid; Protein Serine-Threonine Kinases - physiology; SARS-CoV-2; Sequence Alignment; Severe acute respiratory syndrome coronavirus 2; Signal Transduction - physiology; Unfolded Protein Response; Viral Proteins - chemistry; Viral Proteins - physiology; viruses; X-Box Binding Protein 1 - physiology; Open reading frame 8; SARS-CoV-2; Open reading frame 8 genotypes; Interferon beta; Endoplasmic reticulum stress

•SARS-CoV-2 orf8 genotypes, orf8L and orf8S induced ER stress pathways.•SARS-CoV-2 orf8 genotypes, orf8L and orf8S antagonized interferon Beta production.•SARS-CoV-2 orf8 genotypes, orf8L and orf8S decrease the nuclear translocation of IRF3 induced by poly (I:C).•The effects of orf8L and orf8S are i...