Mir-223 regulates the number and function of myeloid-derived suppressor cells in multiple sclerosis and experimental autoimmune encephalomyelitis

• Published in: Acta neuropathologica Vol. 133; no. 1; pp. 61 - 77
• Main Authors: Cantoni, Claudia, Cignarella, Francesca, Ghezzi, Laura, Mikesell, Bob, Bollman, Bryan, Berrien-Elliott, Melissa M., Ireland, Aaron R., Fehniger, Todd A., Wu, Gregory F., Piccio, Laura
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2017; Springer; Springer Nature B.V
• Subjects: Analysis; Animals; Arginase - metabolism; Brain - metabolism; Brain - pathology; Cell Count; Cell growth; Disease; Encephalomyelitis; Encephalomyelitis, Autoimmune, Experimental - metabolism; Encephalomyelitis, Autoimmune, Experimental - pathology; Humans; Lymphocytes; Medicine; Medicine & Public Health; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Multiple sclerosis; Multiple Sclerosis, Relapsing-Remitting - metabolism; Multiple Sclerosis, Relapsing-Remitting - pathology; Myeloid-Derived Suppressor Cells - metabolism; Myeloid-Derived Suppressor Cells - pathology; Neurosciences; Neutrophils; Original Paper; Pathology; Spinal Cord - metabolism; Spinal Cord - pathology; Spleen - metabolism; Spleen - pathology; STAT3 Transcription Factor - metabolism; T cells; T-Lymphocytes - metabolism; T-Lymphocytes - pathology; St Louis Missouri; United States > US; MiR-223; Multiple sclerosis; MicroRNA; Myeloid-derived suppressor cells

Myeloid-derived cells play important modulatory and effector roles in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells, composed of monocytic (MO) and polymorphonuclear (PMN) fractions,...