Fucoxanthin Attenuates Rifampin-Induced Cytochrome P450 3A4 (CYP3A4) and Multiple Drug Resistance 1 (MDR1) Gene Expression Through Pregnane X Receptor (PXR)-Mediated Pathways in Human Hepatoma HepG2 and Colon Adenocarcinoma LS174T Cells - Liu, Cheng-Ling; Lim, Yun-Ping; Hu, Miao-Lin (Marine drugs, 2012)
Keywords: Adenocarcinoma - drug therapy; Adenocarcinoma - pathology; Algae; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics; Cell Line, Tumor; Colonic Neoplasms - drug therapy; Colonic Neoplasms - pathology; CYP3A4; Cytochrome; Cytochrome P-450 CYP3A - genetics; Drug resistance; fucoxanthin; Hep G2 Cells; Humans; Marine; MDR1; Pregnane X Receptor; Promoter Regions, Genetic; PXR; Receptors, Cytoplasmic and Nuclear - physiology; Receptors, Steroid - antagonists & inhibitors; Receptors, Steroid - physiology; rifampin; Rifampin - pharmacology; RNA, Messenger - analysis; Side effects; Transcriptional Activation; Xanthophylls - pharmacology; MDR1; PXR; drug resistance; CYP3A4; fucoxanthin; rifampin