Has-miR-129-5p's Involvement in Different Disorders, from Digestive Cancer to Neurodegenerative Diseases

• Published in: Biomedicines Vol. 11; no. 7; p. 2058
• Main Authors: Boicean, Adrian, Birsan, Sabrina, Ichim, Cristian, Boeras, Ioana, Roman-Filip, Iulian, Blanca, Grama, Bacila, Ciprian, Fleaca, Radu Sorin, Dura, Horatiu, Roman-Filip, Corina
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.07.2023; MDPI
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Alzheimer's disease; Analysis; Apoptosis; Biomarkers; Cancer; Cancer therapies; Cell cycle; Chemotherapy; Degeneration; Development and progression; Diagnosis; digestive neoplasia; downregulation; Gastric cancer; Gene expression; Genetic markers; Kinases; Lymphatic system; Medical prognosis; Metastases; Metastasis; MicroRNA; MicroRNAs; miR-129-5p; Nervous system; Neurodegenerative diseases; Neurological diseases; Non-coding RNA; Oncology, Experimental; Parkinson's disease; Proteins; Systematic Review; TOR protein; Wnt protein; Romania; digestive neoplasia; neurological diseases; downregulation; miR-129-5p
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines11072058

At present, it is necessary to identify specific biochemical, molecular, and genetic markers that can reliably aid in screening digestive cancer and correlate with the degree of disease development. Has-miR-129-5p is a small, non-coding molecule of RNA, circulating in plasma, gastric juice, and other biological fluids; it plays a protective role in tumoral growth, metastasis, etc. Furthermore, it is involved in various diseases, from the development of digestive cancer in cases of downregulation to neurodegenerative diseases and depression. Methods: We examined meta-analyses, research, and studies related to miR-129-5-p involved in digestive cancer and its implications in cancer processes, as well as metastasis, and described its implications in neurological diseases. Conclusions: Our review outlines that miR-129-5p is a significant controller of different pathways, genes, and proteins and influences different diseases. Some important pathways include the WNT and PI3K/AKT/mTOR pathways; their dysregulation results in digestive neoplasia and neurodegenerative diseases.