Hydrogel Microfilaments toward Intradermal Health Monitoring

Digital health promises a paradigm shift for medicine where biomarkers in individuals are continuously monitored to improve diagnosis and treatment of disease. To that end, a technology for minimally invasive quantification of endogenous analytes in bodily fluids will be required. Here, we describe...

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Published iniScience Vol. 21; pp. 328 - 340
Main Authors Tejavibulya, Nalin, Colburn, David A.M., Marcogliese, Francis A., Yang, Kyung-Ae, Guo, Vincent, Chowdhury, Shilpika, Stojanovic, Milan N., Sia, Samuel K.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 22.11.2019
Elsevier
Subjects
Bioelectronics
Biomedical Materials
Polymers
Bioelectronics
Polymers
Biomedical Materials
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Abstract Digital health promises a paradigm shift for medicine where biomarkers in individuals are continuously monitored to improve diagnosis and treatment of disease. To that end, a technology for minimally invasive quantification of endogenous analytes in bodily fluids will be required. Here, we describe a strategy for designing and fabricating hydrogel microfilaments that can penetrate the skin while allowing for optical fluorescence sensing. The polyacrylamide formulation was selected to provide high elastic modulus in the dehydrated state and optical transparency in the hydrated state. The microfilaments can be covalently tethered to a fluorescent aptamer to enable functional sensing. The microfilament array can penetrate the skin with low pain and without breaking, contact the dermal interstitial fluid, and be easily removed from the skin. In the future, hydrogel microfilaments could be integrated with a wearable fluorometer to serve as a platform for continuous, minimally invasive monitoring of intradermal biomarkers. [Display omitted] •Polyacrylamide hydrogel microfilaments were fabricated via replica molding•Microfilaments are stiff, when dehydrated, and optically transparent, when hydrated•Fluorescent aptamer can be tethered to hydrogel matrix for in situ analyte sensing•Microfilaments penetrate skin with low pain and contact interstitial fluid Bioelectronics; Polymers; Biomedical Materials
AbstractList Digital health promises a paradigm shift for medicine where biomarkers in individuals are continuously monitored to improve diagnosis and treatment of disease. To that end, a technology for minimally invasive quantification of endogenous analytes in bodily fluids will be required. Here, we describe a strategy for designing and fabricating hydrogel microfilaments that can penetrate the skin while allowing for optical fluorescence sensing. The polyacrylamide formulation was selected to provide high elastic modulus in the dehydrated state and optical transparency in the hydrated state. The microfilaments can be covalently tethered to a fluorescent aptamer to enable functional sensing. The microfilament array can penetrate the skin with low pain and without breaking, contact the dermal interstitial fluid, and be easily removed from the skin. In the future, hydrogel microfilaments could be integrated with a wearable fluorometer to serve as a platform for continuous, minimally invasive monitoring of intradermal biomarkers. [Display omitted] •Polyacrylamide hydrogel microfilaments were fabricated via replica molding•Microfilaments are stiff, when dehydrated, and optically transparent, when hydrated•Fluorescent aptamer can be tethered to hydrogel matrix for in situ analyte sensing•Microfilaments penetrate skin with low pain and contact interstitial fluid Bioelectronics; Polymers; Biomedical Materials
Digital health promises a paradigm shift for medicine where biomarkers in individuals are continuously monitored to improve diagnosis and treatment of disease. To that end, a technology for minimally invasive quantification of endogenous analytes in bodily fluids will be required. Here, we describe a strategy for designing and fabricating hydrogel microfilaments that can penetrate the skin while allowing for optical fluorescence sensing. The polyacrylamide formulation was selected to provide high elastic modulus in the dehydrated state and optical transparency in the hydrated state. The microfilaments can be covalently tethered to a fluorescent aptamer to enable functional sensing. The microfilament array can penetrate the skin with low pain and without breaking, contact the dermal interstitial fluid, and be easily removed from the skin. In the future, hydrogel microfilaments could be integrated with a wearable fluorometer to serve as a platform for continuous, minimally invasive monitoring of intradermal biomarkers.
Digital health promises a paradigm shift for medicine where biomarkers in individuals are continuously monitored to improve diagnosis and treatment of disease. To that end, a technology for minimally invasive quantification of endogenous analytes in bodily fluids will be required. Here, we describe a strategy for designing and fabricating hydrogel microfilaments that can penetrate the skin while allowing for optical fluorescence sensing. The polyacrylamide formulation was selected to provide high elastic modulus in the dehydrated state and optical transparency in the hydrated state. The microfilaments can be covalently tethered to a fluorescent aptamer to enable functional sensing. The microfilament array can penetrate the skin with low pain and without breaking, contact the dermal interstitial fluid, and be easily removed from the skin. In the future, hydrogel microfilaments could be integrated with a wearable fluorometer to serve as a platform for continuous, minimally invasive monitoring of intradermal biomarkers. • Polyacrylamide hydrogel microfilaments were fabricated via replica molding • Microfilaments are stiff, when dehydrated, and optically transparent, when hydrated • Fluorescent aptamer can be tethered to hydrogel matrix for in situ analyte sensing • Microfilaments penetrate skin with low pain and contact interstitial fluid Bioelectronics; Polymers; Biomedical Materials
Digital health promises a paradigm shift for medicine where biomarkers in individuals are continuously monitored to improve diagnosis and treatment of disease. To that end, a technology for minimally invasive quantification of endogenous analytes in bodily fluids will be required. Here, we describe a strategy for designing and fabricating hydrogel microfilaments that can penetrate the skin while allowing for optical fluorescence sensing. The polyacrylamide formulation was selected to provide high elastic modulus in the dehydrated state and optical transparency in the hydrated state. The microfilaments can be covalently tethered to a fluorescent aptamer to enable functional sensing. The microfilament array can penetrate the skin with low pain and without breaking, contact the dermal interstitial fluid, and be easily removed from the skin. In the future, hydrogel microfilaments could be integrated with a wearable fluorometer to serve as a platform for continuous, minimally invasive monitoring of intradermal biomarkers. : Bioelectronics; Polymers; Biomedical Materials Subject Areas: Bioelectronics, Polymers, Biomedical Materials
Author Colburn, David A.M.
Guo, Vincent
Tejavibulya, Nalin
Yang, Kyung-Ae
Sia, Samuel K.
Chowdhury, Shilpika
Stojanovic, Milan N.
Marcogliese, Francis A.
AuthorAffiliation 2 Division of Experimental Therapeutics, Department of Medicine, Columbia University, New York, NY 10032, USA
1 Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, NY 10027, USA
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Keywords Bioelectronics
Polymers
Biomedical Materials
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