Down-regulation of cathepsin S and matrix metalloproteinase-9 via Src, a non-receptor tyrosine kinase, suppresses triple-negative breast cancer growth and metastasis

• Published in: Experimental & molecular medicine Vol. 50; no. 9; pp. 1 - 14
• Main Authors: Gautam, Jaya, Banskota, Suhrid, Lee, Hyunji, Lee, Yu-Jeong, Jeon, Yong Hyun, Kim, Jung-Ae, Jeong, Byeong-Seon
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.09.2018; Springer Nature B.V; Nature Publishing Group; 생화학분자생물학회
• Subjects: 1-Phosphatidylinositol 3-kinase; 13/89; 14/35; 59/5; 631/67/1059/99; 692/308/153; 96/95; Affinity; AKT protein; Aminopyridines - pharmacology; Animals; Biomedical and Life Sciences; Biomedicine; Breast cancer; Cathepsin S; Cathepsins - metabolism; Cell Proliferation; Cell Survival; Chickens; Chorioallantoic membrane; Chorioallantoic Membrane - metabolism; Cytotoxicity; Down-regulation; Down-Regulation - drug effects; Drug development; Epithelial cells; Extracellular signal-regulated kinase; Female; Gelatinase; Gelatinase B; Humans; Kinases; Matrix metalloproteinase; Matrix Metalloproteinase 9 - metabolism; MCF-7 Cells; Medical Biochemistry; Metalloproteinase; Metastases; Metastasis; Mice; Molecular Medicine; Neoplasm Invasiveness; Neoplasm Metastasis; Protein-tyrosine kinase receptors; Raf protein; Signal Transduction - drug effects; siRNA; src-Family Kinases - metabolism; Stem Cells; Triple Negative Breast Neoplasms - enzymology; Triple Negative Breast Neoplasms - pathology; Xenograft Model Antitumor Assays; Xenografts; 생화학

Triple-negative breast cancer (TNBC) is a highly metastatic breast cancer with poor prognosis. In the present study, we demonstrated that Src, a non-receptor tyrosine kinase, might provide an effective therapeutic strategy to overcome TNBC invasion and metastasis, which are mediated via the synergis...