Activation and enhancement of Fredericamycin A production in deepsea-derived Streptomyces somaliensis SCSIO ZH66 by using ribosome engineering and response surface methodology

• Published in: Microbial cell factories Vol. 14; no. 1; p. 64
• Main Authors: Zhang, Yonghe, Huang, Huiming, Xu, Shanshan, Wang, Bo, Ju, Jianhua, Tan, Huarong, Li, Wenli
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.05.2015; BioMed Central
• Subjects: Fermentation; Genetic Engineering; Isoquinolines - metabolism; Methods; Molecular Sequence Data; Multigene Family - genetics; Mutation; Spiro Compounds - metabolism; Streptomyces - genetics

Marine microorganisms are an important source of new drug leads. However, the discovery and sustainable production of these compounds are often hampered due to the unavailable expression of cryptic biosynthetic gene clusters or limited titer. Ribosome engineering and response surface methodology (RS...