COVID-19, Blood Lipid Changes, and Thrombosis

• Published in: Biomedicines Vol. 11; no. 4; p. 1181
• Main Authors: Farooqui, Akhlaq A, Farooqui, Tahira, Sun, Grace Y, Lin, Teng-Nan, Teh, Daniel B L, Ong, Wei-Yi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2023; MDPI
• Subjects: Arachidonic acid; autotaxin; Blood; Blood lipids; Blood platelets; Blood vessels; Cell membranes; Clotting; Coronaviruses; COVID-19; Cytokine storm; Eicosanoids; Endothelial cells; Erythrocytes; Genomes; Health aspects; Infections; Inflammation; Leukocytes (neutrophilic); Lipid metabolism; Lungs; Lysophosphatidic acid; Lysophosphatidylcholine; lysophospholipase D; Medical prognosis; Neutrophils; Oxidative stress; Pathogenesis; Phospholipase A2; Phospholipids; PLA2G2A; Platelet-activating factor; Platelets; Prostaglandin H2; Proteins; Review; secretory phospholipase A2; Severe acute respiratory syndrome coronavirus 2; sPLA2-IIA; Thrombosis; Thromboxane A2; Tumor necrosis factor-TNF; Viral infections; Virulence; China; sPLA2-IIA; neutrophil extracellular traps; CAC; macrothrombi; autotaxin; PLA2G2A; microthrombi; C16:0 ceramide; brain endothelial cells; secretory phospholipase A2; stroke; platelets; COVID-19-associated-coagulopathy; COVID-19; NETs; lysophosphatidic acid; thrombosis; lysophospholipase D; LPA; pneumocytes

Although there is increasing evidence that oxidative stress and inflammation induced by COVID-19 may contribute to increased risk and severity of thromboses, the underlying mechanism(s) remain to be understood. The purpose of this review is to highlight the role of blood lipids in association with t...