Interleukin-1 receptor antagonist VNTR-polymorphism in inflammatory bowel disease

• Published in: Genes and immunity Vol. 3; no. 7; pp. 400 - 406
• Main Authors: Vijgen, L, Van Gysel, M, Rector, A, Thoelen, I, Esters, N, Ceelen, T, Vangoidsenhoven, E, Vermeire, S, Rutgeerts, P, Van Ranst, M
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.11.2002
• Subjects: Adolescent; Adult; Aged; Alleles; Carrier Proteins - genetics; Child; Crohn's disease; Cytokines; Environmental factors; Etiology; Gene Frequency; Gene polymorphism; Genetic factors; Genetic Predisposition to Disease; Genotype & phenotype; Heterozygotes; Homozygotes; Humans; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - genetics; Interleukin 1; Interleukin 1 receptor antagonist; Interleukin 1 Receptor Antagonist Protein; Interleukin 1 receptors; Intestine; Intracellular Signaling Peptides and Proteins; Middle Aged; Minisatellite Repeats; Molecular Sequence Data; NOD2 protein; Nod2 Signaling Adaptor Protein; Polymorphism; Receptors, Interleukin-1 - antagonists & inhibitors; Sialoglycoproteins - genetics; Ulcerative colitis

Both genetic and environmental factors have been implicated in the etiology of inflammatory bowel diseases (IBD) i.e., Crohn's disease (CD) and ulcerative colitis (UC). Polymorphisms in cytokine genes are likely to influence an individual's predisposition to IBD. In intron 2 of the interle...