Inflammaging: Expansion of Molecular Phenotype and Role in Age-Associated Female Infertility

• Published in: Biomedicines Vol. 12; no. 9; p. 1987
• Main Authors: Ivanov, Dmitry, Drobintseva, Anna, Rodichkina, Valeriia, Mironova, Ekaterina, Zubareva, Tatyana, Krylova, Yuliya, Morozkina, Svetlana, Marasco, Maria Greta Pia, Mazzoccoli, Gianluigi, Nasyrov, Ruslan, Kvetnoy, Igor
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.09.2024; MDPI
• Subjects: Age; Aging; Analysis; Cell culture; Cell cycle; Confocal microscopy; endometrial cells; Endometrium; Extracellular vesicles; female infertility; Gene expression; Genetic aspects; Genotoxicity; Genotype & phenotype; Immunofluorescence; Infertility; Infertility, Female; Inflammation; Interleukin 6; Interleukin 8; Menstruation; molecular markers; mRNA; Pediatrics; Penicillin; Phenotypes; Pregnancy; Reproductive system; RNA; SASP; Senescence; Statistical analysis; Therapeutic targets; Ultraviolet radiation; Russia; United States > US; Netherlands; China; endometrial cells; aging; female infertility; SASP; molecular markers

Cellular aging is considered as one of the main factors implicated in female infertility. We evaluated the expression of senescence-associated secretory phenotype (SASP) markers and additional molecular factors in an in vitro model of cellular aging. We induced genotoxic stress (UVB/UVA ray irradiat...