NEK8 promotes the progression of gastric cancer by reprogramming asparagine metabolism

• Published in: Molecular medicine (Cambridge, Mass.) Vol. 31; no. 1; pp. 3 - 17
• Main Authors: Wang, Mingliang, Yu, Kexun, Meng, Futao, Wang, Huizhen, Li, Yongxiang
• Format: Journal Article
• Language: English
• Published: England BioMed Central 06.01.2025; BMC
• Subjects: Animals; ASNS; Asparagine - metabolism; Aspartate-Ammonia Ligase - genetics; Aspartate-Ammonia Ligase - metabolism; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor; Cell Line, Tumor; Cell Proliferation; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mechanistic Target of Rapamycin Complex 1 - metabolism; Mice; NEK8; NIMA-Related Kinases - genetics; NIMA-Related Kinases - metabolism; Prognosis; Signal Transduction; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Ubiquitination; NEK8; ASNS; Ubiquitination; Asparagine metabolism

Several members of the NIMA-related kinase (NEK) family have been implicated in tumor progression; however, the role and underlying mechanisms of NEK8 in gastric cancer (GC) remain unclear. This study revealed a significant upregulation of NEK8 in GC, identifying it as an independent prognostic mark...