Effects of dietary supplementation with Lactobacillus acidophilus on the performance, intestinal physical barrier function, and the expression of NOD-like receptors in weaned piglets
supplementation is beneficial to the barrier function of the intestinal physical barrier in piglets. However, the mechanisms underlying this beneficial function remain largely unknown. Here, we investigated the effects of dietary supplementation with on the performance, intestinal physical barrier f...
Saved in:
Published in | PeerJ (San Francisco, CA) Vol. 6; p. e6060 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
PeerJ. Ltd
18.12.2018
PeerJ, Inc PeerJ Inc |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | supplementation is beneficial to the barrier function of the intestinal physical barrier in piglets. However, the mechanisms underlying this beneficial function remain largely unknown. Here, we investigated the effects of dietary supplementation with
on the performance, intestinal physical barrier functioning, and NOD-like receptors (NLRs) expression in weaned piglets. Sixteen weaned piglets were randomly allocated to two groups. The control group received a corn-soybean basal diet, while the treatment group received the same diet adding 0.1%
, for 14 days. As a result, dietary
supplementation was found to increase the average daily gain (ADG) (
< 0.05), reduced serum diamine oxidase (DAO) activity (
< 0.05), increased the mRNA expression and protein abundance of occludin in the jejunum and ileum (
< 0.01), reduced the mRNA levels of NOD1 (
< 0.01), receptor interacting serine/threonine kinase 2 (RIPK2) (
< 0.05), nuclear factor κB (NF-κB) (
< 0.01), NLR family pyrin domain containing 3 (NLRP3) (
< 0.01), caspase-1 (
< 0.01), interleukin 1β (IL-1β) (
< 0.05) and IL-18 (
< 0.01) in the jejunum tissues of the weaned pigs. The expression of NLRP3 (
< 0.05), caspase-1 (
< 0.01), IL-1β (
< 0.05) and IL-18 (
< 0.05) was also reduced in the ileum tissues of the weaned pigs. These results showed that
supplementation improves the growth performance, enhances the intestinal physical barrier function, and inhibits the expression of NOD1 and NLRP3 signaling-pathway-related genes in jejunum and ileum tissues. They also suggest that
enhances the intestinal physical barrier functioning by inhibiting IL-1β and IL-18 pro-inflammatory cytokines via the NOD1/NLRP3 signaling pathway in weaned piglets. |
---|---|
AbstractList | Lactobacillus supplementation is beneficial to the barrier function of the intestinal physical barrier in piglets. However, the mechanisms underlying this beneficial function remain largely unknown. Here, we investigated the effects of dietary supplementation with Lactobacillus acidophilus on the performance, intestinal physical barrier functioning, and NOD-like receptors (NLRs) expression in weaned piglets. Sixteen weaned piglets were randomly allocated to two groups. The control group received a corn-soybean basal diet, while the treatment group received the same diet adding 0.1% L. acidophilus, for 14 days. As a result, dietary L. acidophilus supplementation was found to increase the average daily gain (ADG) (P < 0.05), reduced serum diamine oxidase (DAO) activity (P < 0.05), increased the mRNA expression and protein abundance of occludin in the jejunum and ileum (P < 0.01), reduced the mRNA levels of NOD1 (P < 0.01), receptor interacting serine/threonine kinase 2 (RIPK2) (P < 0.05), nuclear factor κB (NF-κB) (P < 0.01), NLR family pyrin domain containing 3 (NLRP3) (P < 0.01), caspase-1 (P < 0.01), interleukin 1β (IL-1β) (P < 0.05) and IL-18 (P < 0.01) in the jejunum tissues of the weaned pigs. The expression of NLRP3 (P < 0.05), caspase-1 (P < 0.01), IL-1β (P < 0.05) and IL-18 (P < 0.05) was also reduced in the ileum tissues of the weaned pigs. These results showed that L. acidophilus supplementation improves the growth performance, enhances the intestinal physical barrier function, and inhibits the expression of NOD1 and NLRP3 signaling-pathway-related genes in jejunum and ileum tissues. They also suggest that L. acidophilus enhances the intestinal physical barrier functioning by inhibiting IL-1β and IL-18 pro-inflammatory cytokines via the NOD1/NLRP3 signaling pathway in weaned piglets. Lactobacillus supplementation is beneficial to the barrier function of the intestinal physical barrier in piglets. However, the mechanisms underlying this beneficial function remain largely unknown. Here, we investigated the effects of dietary supplementation with Lactobacillus acidophilus on the performance, intestinal physical barrier functioning, and NOD-like receptors (NLRs) expression in weaned piglets. Sixteen weaned piglets were randomly allocated to two groups. The control group received a corn-soybean basal diet, while the treatment group received the same diet adding 0.1% L.acidophilus, for 14 days. As a result, dietary L. acidophilus supplementation was found to increase the average daily gain (ADG) (P<0.05), reduced serum diamine oxidase (DAO) activity (P<0.05), increased the mRNA expression and protein abundance of occludin in the jejunum and ileum (P<0.01), reduced the mRNA levels of NOD1 (P<0.01), receptor interacting serine/threonine kinase 2 (RIPK2) (P<0.05), nuclear factor [kappa]B (NF-[kappa]B) (P<0.01), NLR family pyrin domain containing 3 (NLRP3) (P<0.01), caspase-1 (P<0.01), interleukin 1[beta] (IL-1[beta]) (P<0.05) and IL-18 (P<0.01) in the jejunum tissues of the weaned pigs. The expression of NLRP3 (P<0.05), caspase-1 (P<0.01), IL-1[beta] (P<0.05) and IL-18 (P<0.05) was also reduced in the ileum tissues of the weaned pigs. These results showed that L. acidophilus supplementation improves the growth performance, enhances the intestinal physical barrier function, and inhibits the expression of NOD1 and NLRP3 signaling-pathway-related genes in jejunum and ileum tissues. They also suggest that L. acidophilus enhances the intestinal physical barrier functioning by inhibiting IL-1[beta] and IL-18 pro-inflammatory cytokines via the NOD1/NLRP3 signaling pathway in weaned piglets. supplementation is beneficial to the barrier function of the intestinal physical barrier in piglets. However, the mechanisms underlying this beneficial function remain largely unknown. Here, we investigated the effects of dietary supplementation with on the performance, intestinal physical barrier functioning, and NOD-like receptors (NLRs) expression in weaned piglets. Sixteen weaned piglets were randomly allocated to two groups. The control group received a corn-soybean basal diet, while the treatment group received the same diet adding 0.1% , for 14 days. As a result, dietary supplementation was found to increase the average daily gain (ADG) ( < 0.05), reduced serum diamine oxidase (DAO) activity ( < 0.05), increased the mRNA expression and protein abundance of occludin in the jejunum and ileum ( < 0.01), reduced the mRNA levels of NOD1 ( < 0.01), receptor interacting serine/threonine kinase 2 (RIPK2) ( < 0.05), nuclear factor κB (NF-κB) ( < 0.01), NLR family pyrin domain containing 3 (NLRP3) ( < 0.01), caspase-1 ( < 0.01), interleukin 1β (IL-1β) ( < 0.05) and IL-18 ( < 0.01) in the jejunum tissues of the weaned pigs. The expression of NLRP3 ( < 0.05), caspase-1 ( < 0.01), IL-1β ( < 0.05) and IL-18 ( < 0.05) was also reduced in the ileum tissues of the weaned pigs. These results showed that supplementation improves the growth performance, enhances the intestinal physical barrier function, and inhibits the expression of NOD1 and NLRP3 signaling-pathway-related genes in jejunum and ileum tissues. They also suggest that enhances the intestinal physical barrier functioning by inhibiting IL-1β and IL-18 pro-inflammatory cytokines via the NOD1/NLRP3 signaling pathway in weaned piglets. Lactobacillus supplementation is beneficial to the barrier function of the intestinal physical barrier in piglets. However, the mechanisms underlying this beneficial function remain largely unknown. Here, we investigated the effects of dietary supplementation with Lactobacillus acidophilus on the performance, intestinal physical barrier functioning, and NOD-like receptors (NLRs) expression in weaned piglets. Sixteen weaned piglets were randomly allocated to two groups. The control group received a corn-soybean basal diet, while the treatment group received the same diet adding 0.1% L. acidophilus , for 14 days. As a result, dietary L. acidophilus supplementation was found to increase the average daily gain (ADG) ( P < 0.05), reduced serum diamine oxidase (DAO) activity ( P < 0.05), increased the mRNA expression and protein abundance of occludin in the jejunum and ileum ( P < 0.01), reduced the mRNA levels of NOD1 ( P < 0.01), receptor interacting serine/threonine kinase 2 (RIPK2) ( P < 0.05), nuclear factor κB (NF-κB) ( P < 0.01), NLR family pyrin domain containing 3 (NLRP3) ( P < 0.01), caspase-1 ( P < 0.01), interleukin 1β (IL-1β) ( P < 0.05) and IL-18 ( P < 0.01) in the jejunum tissues of the weaned pigs. The expression of NLRP3 ( P < 0.05), caspase-1 ( P < 0.01), IL-1β ( P < 0.05) and IL-18 ( P < 0.05) was also reduced in the ileum tissues of the weaned pigs. These results showed that L. acidophilus supplementation improves the growth performance, enhances the intestinal physical barrier function, and inhibits the expression of NOD1 and NLRP3 signaling-pathway-related genes in jejunum and ileum tissues. They also suggest that L. acidophilus enhances the intestinal physical barrier functioning by inhibiting IL-1β and IL-18 pro-inflammatory cytokines via the NOD1/NLRP3 signaling pathway in weaned piglets. Lactobacillus supplementation is beneficial to the barrier function of the intestinal physical barrier in piglets. However, the mechanisms underlying this beneficial function remain largely unknown. Here, we investigated the effects of dietary supplementation with Lactobacillus acidophilus on the performance, intestinal physical barrier functioning, and NOD-like receptors (NLRs) expression in weaned piglets. Sixteen weaned piglets were randomly allocated to two groups. The control group received a corn-soybean basal diet, while the treatment group received the same diet adding 0.1% L. acidophilus, for 14 days. As a result, dietary L. acidophilus supplementation was found to increase the average daily gain (ADG) (P < 0.05), reduced serum diamine oxidase (DAO) activity (P < 0.05), increased the mRNA expression and protein abundance of occludin in the jejunum and ileum (P < 0.01), reduced the mRNA levels of NOD1 (P < 0.01), receptor interacting serine/threonine kinase 2 (RIPK2) (P < 0.05), nuclear factor κB (NF-κB) (P < 0.01), NLR family pyrin domain containing 3 (NLRP3) (P < 0.01), caspase-1 (P < 0.01), interleukin 1β (IL-1β) (P < 0.05) and IL-18 (P < 0.01) in the jejunum tissues of the weaned pigs. The expression of NLRP3 (P < 0.05), caspase-1 (P < 0.01), IL-1β (P < 0.05) and IL-18 (P < 0.05) was also reduced in the ileum tissues of the weaned pigs. These results showed that L. acidophilus supplementation improves the growth performance, enhances the intestinal physical barrier function, and inhibits the expression of NOD1 and NLRP3 signaling-pathway-related genes in jejunum and ileum tissues. They also suggest that L. acidophilus enhances the intestinal physical barrier functioning by inhibiting IL-1β and IL-18 pro-inflammatory cytokines via the NOD1/NLRP3 signaling pathway in weaned piglets. |
ArticleNumber | e6060 |
Audience | Academic |
Author | Chen, Longbin Du, Chenhong Wang, Zhixiang Liu, Qian Wang, Shiqiong Li, Haihua Yang, Dongji Zhu, Qi |
Author_xml | – sequence: 1 givenname: Shiqiong surname: Wang fullname: Wang, Shiqiong organization: College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China – sequence: 2 givenname: Haihua surname: Li fullname: Li, Haihua organization: College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China – sequence: 3 givenname: Chenhong surname: Du fullname: Du, Chenhong organization: College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China – sequence: 4 givenname: Qian surname: Liu fullname: Liu, Qian organization: College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China – sequence: 5 givenname: Dongji surname: Yang fullname: Yang, Dongji organization: College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China – sequence: 6 givenname: Longbin surname: Chen fullname: Chen, Longbin organization: Tianjin Institute of Animal Husbandry and Veterinary Medicine, Tianjin Academy of Agricultural Sciences, Tianjin, China – sequence: 7 givenname: Qi surname: Zhu fullname: Zhu, Qi organization: Tianjin Institute of Animal Husbandry and Veterinary Medicine, Tianjin Academy of Agricultural Sciences, Tianjin, China – sequence: 8 givenname: Zhixiang surname: Wang fullname: Wang, Zhixiang organization: College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30588399$$D View this record in MEDLINE/PubMed |
BookMark | eNptktFu0zAUhiM0xMbYDQ-ALCEhhNYSx3Hs3CBNY8Ckit3AteXax42LGwfbYezFeD6cdowWkVz4yPnOb-c__9PiqPc9FMVzXM4Zw-ztABDW86ZsykfFSYUbNuOEtkd79XFxFuO6zA-vmpKTJ8UxKSnnpG1Pil9XxoBKEXmDtIUkwx2K4zA42ECfZLK-R7c2dWghVfJLqaxzY0R51X7o7FRnInWABgjGh43sFZwj2yeIyfbSoaG7i1blYilDsBCQGXs16Z4j2ettK_wcAsQ4nZWv8fnm_czZb4ACKBiSDzHLoVuQPWg02JWDFJ8Vj410Ec7u19Pi64erL5efZoubj9eXF4uZoqxMs8pUCuqKEA4tbqGWTJEGG8NpvaS6JWyJdYkrqWqqKWlrWhnNpdacVGxZE0pOi-udrvZyLYZgN9kg4aUV2w0fVkKGZJUDwZTWLTAiGwY1xk2rgWFDTa0wI4SqrPVupzWMyw1olf0N0h2IHn7pbSdW_odoSFkxjrPA63uB4L-P2V-xsVGBc9kZP0aRJ47LhmJaZfTlP-jajyGPY6IoxzXjJf5LrWT-Adsbn89Vk6i4oE2DK9ryyYP5f6j8athYldNobN4_aHi119CBdKmL3o3T0OMh-GYHquBjDGAezMClmNIttukWU7oz_GLfvgf0T5bJb7oJ-dM |
CitedBy_id | crossref_primary_10_1016_j_aqrep_2020_100440 crossref_primary_10_1016_j_phrs_2020_104978 crossref_primary_10_3390_microorganisms12071263 crossref_primary_10_1016_j_jff_2020_104058 crossref_primary_10_3390_ani13193098 crossref_primary_10_1016_j_aquaculture_2023_740208 crossref_primary_10_1186_s13063_020_04490_0 crossref_primary_10_2144_fsoa_2020_0153 crossref_primary_10_2478_fv_2019_0039 crossref_primary_10_1016_j_phrs_2021_105775 |
Cites_doi | 10.1007/s10482-015-0380-z 10.3748/wjg.v8.i1.168 10.1371/journal.pone.0158865 10.1016/j.physbeh.2016.11.012 10.1016/j.bcp.2013.03.008 10.1038/ni.1960 10.1016/j.immuni.2010.03.003 10.1186/s12866-015-0372-1 10.1073/pnas.1000092107 10.1111/j.1749-6632.2009.04025.x 10.1007/s11033-010-0237-5 10.1016/j.smim.2015.03.011 10.1017/S0007114510005660 10.1097/01.mco.0000247477.02650.51 10.1158/0008-5472.CAN-15-2272 10.1155/2017/6519785 10.1016/j.burns.2003.09.032 10.1038/nature07450 10.1021/jf403288r 10.1016/j.mcp.2017.05.009 10.1016/j.ceb.2016.05.006 10.1002/eji.201040827 10.1016/j.ejcb.2011.06.005 10.1128/JVI.00202-17 10.1136/gut.2003.026252 10.1016/j.ajpath.2017.02.006 10.1111/lam.12201 10.1051/animres:2004018 10.1242/jcs.113399 10.3390/nu9060559 10.1016/j.vetimm.2016.03.005 10.4049/jimmunol.176.1.484 10.1002/jemt.22831 10.1038/nri2653 10.1091/mbc.E12-09-0688 10.1177/1753425916664124 10.1038/35067088 10.4161/19490976.2014.990784 10.1038/416194a 10.3389/fimmu.2017.01168 10.1016/j.immuni.2010.02.012 10.1172/JCI39481 10.4014/jmb.1510.10089 10.1136/gut.2009.197822 10.1136/gutjnl-2014-308419 10.1007/s10482-009-9339-2 10.1002/jsfa.7866 10.1371/journal.pone.0146312 10.1093/jn/137.12.2709 10.1038/mi.2013.94 10.1172/jci.insight.96322 10.1038/srep40418 10.1016/j.anifeedsci.2014.12.010 10.1038/srep29142 10.1016/S0025-6196(11)63729-4 |
ContentType | Journal Article |
Copyright | COPYRIGHT 2018 PeerJ. Ltd. 2018 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2018 Wang et al. 2018 Wang et al. |
Copyright_xml | – notice: COPYRIGHT 2018 PeerJ. Ltd. – notice: 2018 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2018 Wang et al. 2018 Wang et al. |
DBID | NPM AAYXX CITATION 3V. 7XB 88I 8FE 8FH 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO GNUQQ HCIFZ LK8 M2P M7P PIMPY PQEST PQQKQ PQUKI PRINS Q9U 7X8 5PM DOA |
DOI | 10.7717/peerj.6060 |
DatabaseName | PubMed CrossRef ProQuest Central (Corporate) ProQuest Central (purchase pre-March 2016) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection AUTh Library subscriptions: ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea ProQuest Central Student SciTech Premium Collection Biological Sciences Science Database Biological Science Database Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
DatabaseTitle | PubMed CrossRef Publicly Available Content Database ProQuest Science Journals (Alumni Edition) ProQuest Central Student ProQuest Biological Science Collection ProQuest Central Basic ProQuest Central Essentials ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection Biological Science Database ProQuest SciTech Collection ProQuest Central China ProQuest Central ProQuest One Academic UKI Edition Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | PubMed CrossRef Publicly Available Content Database |
Database_xml | – sequence: 1 dbid: DOA name: Open Access: DOAJ - Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: BENPR name: AUTh Library subscriptions: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Veterinary Medicine Zoology |
EISSN | 2167-8359 |
EndPage | e6060 |
ExternalDocumentID | oai_doaj_org_article_7cdd9e73a67e41169de71f5f4c17335c A566125985 10_7717_peerj_6060 30588399 |
Genre | Journal Article |
GrantInformation_xml | – fundername: National Natural Science Foundation of China grantid: Project NO. 31702147 – fundername: Tianjin Natural Science Foundation grantid: Project NO. 18JCYBJC30000 |
GroupedDBID | 3V. 53G 5VS 88I 8FE 8FH AAFWJ ABUWG ADBBV ADRAZ AENEX AFKRA AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ CCPQU DIK DWQXO ECGQY GNUQQ GROUPED_DOAJ GX1 H13 HCIFZ HYE IAO IEA IHR IHW ITC KQ8 LK8 M2P M48 M7P M~E NPM OK1 PIMPY PQQKQ PROAC RPM W2D YAO AAYXX CITATION 7XB 8FK PQEST PQUKI PRINS Q9U 7X8 5PM |
ID | FETCH-LOGICAL-c570t-2f2ce42338e919e4a7c361ff854b5d937b1d012ac45d539452fd8add8327b4353 |
IEDL.DBID | RPM |
ISSN | 2167-8359 |
IngestDate | Fri Oct 04 13:04:06 EDT 2024 Tue Sep 17 21:26:39 EDT 2024 Sat Aug 17 00:15:04 EDT 2024 Thu Oct 10 18:03:37 EDT 2024 Thu Feb 22 23:45:05 EST 2024 Sat Dec 16 00:17:10 EST 2023 Tue Aug 20 21:57:22 EDT 2024 Fri Aug 23 02:11:04 EDT 2024 Sat Sep 28 08:32:18 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | Intestinal physical barrier NLRs Weaned piglet Lactobacillus acidophilus |
Language | English |
License | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c570t-2f2ce42338e919e4a7c361ff854b5d937b1d012ac45d539452fd8add8327b4353 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302781/ |
PMID | 30588399 |
PQID | 2158147801 |
PQPubID | 2045935 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_7cdd9e73a67e41169de71f5f4c17335c pubmedcentral_primary_oai_pubmedcentral_nih_gov_6302781 proquest_miscellaneous_2161065152 proquest_journals_2158147801 gale_infotracmisc_A566125985 gale_infotracacademiconefile_A566125985 gale_healthsolutions_A566125985 crossref_primary_10_7717_peerj_6060 pubmed_primary_30588399 |
PublicationCentury | 2000 |
PublicationDate | 2018-12-18 |
PublicationDateYYYYMMDD | 2018-12-18 |
PublicationDate_xml | – month: 12 year: 2018 text: 2018-12-18 day: 18 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: San Diego – name: San Diego, USA |
PublicationTitle | PeerJ (San Francisco, CA) |
PublicationTitleAlternate | PeerJ |
PublicationYear | 2018 |
Publisher | PeerJ. Ltd PeerJ, Inc PeerJ Inc |
Publisher_xml | – name: PeerJ. Ltd – name: PeerJ, Inc – name: PeerJ Inc |
References | Liu (10.7717/peerj.6060/ref-20) 2011; 38 Pahwa (10.7717/peerj.6060/ref-31) 2017; 2017 Peng (10.7717/peerj.6060/ref-32) 2004; 30 Song-Zhao (10.7717/peerj.6060/ref-37) 2014; 7 Buschmann (10.7717/peerj.6060/ref-6) 2013; 24 Liu (10.7717/peerj.6060/ref-21) 2014; 62 Sperandio (10.7717/peerj.6060/ref-38) 2015; 27 Tsukita (10.7717/peerj.6060/ref-40) 2001; 2 Balda (10.7717/peerj.6060/ref-3) 2016; 42 Mak’Anyengo (10.7717/peerj.6060/ref-25) 2018; 3 Wang (10.7717/peerj.6060/ref-46) 2014; 58 Dupaul-Chicoine (10.7717/peerj.6060/ref-8) 2010; 32 Roselli (10.7717/peerj.6060/ref-35) 2007; 137 Lei-Leston (10.7717/peerj.6060/ref-14) 2017; 8 Magalhaes (10.7717/peerj.6060/ref-23) 2011; 41 Turner (10.7717/peerj.6060/ref-41) 2009; 9 Chen (10.7717/peerj.6060/ref-7) 2016; 22 Ménard (10.7717/peerj.6060/ref-28) 2004; 53 Qiao (10.7717/peerj.6060/ref-33) 2015; 107 Lan (10.7717/peerj.6060/ref-12) 2017; 97 Liu (10.7717/peerj.6060/ref-18) 2017; 9 Majumdar (10.7717/peerj.6060/ref-24) 2017; 35 Liu (10.7717/peerj.6060/ref-17) 2013; 85 Zhao (10.7717/peerj.6060/ref-55) 2015; 200 Mao (10.7717/peerj.6060/ref-26) 2016; 11 Yan (10.7717/peerj.6060/ref-52) 2006; 9 Li (10.7717/peerj.6060/ref-16) 2002; 8 Wells (10.7717/peerj.6060/ref-48) 2011; 108 Asano (10.7717/peerj.6060/ref-1) 2016; 76 Xie (10.7717/peerj.6060/ref-51) 2016; 11 Liu (10.7717/peerj.6060/ref-19) 2017; 7 Volksdorf (10.7717/peerj.6060/ref-43) 2017; 187 Vella (10.7717/peerj.6060/ref-42) 1998; 73 Bacou (10.7717/peerj.6060/ref-2) 2017; 169 Bauer (10.7717/peerj.6060/ref-4) 2010; 59 Mariano (10.7717/peerj.6060/ref-27) 2011; 90 Miao (10.7717/peerj.6060/ref-29) 2010; 11 Koch (10.7717/peerj.6060/ref-10) 2009; 1165 Zaki (10.7717/peerj.6060/ref-54) 2010; 32 Lallès (10.7717/peerj.6060/ref-11) 2004; 53 Luo (10.7717/peerj.6060/ref-22) 2017; 91 Tanaka (10.7717/peerj.6060/ref-39) 2015; 64 Li (10.7717/peerj.6060/ref-15) 2016; 6 Sardi (10.7717/peerj.6060/ref-36) 2017; 80 Yang (10.7717/peerj.6060/ref-53) 2015; 15 Wang (10.7717/peerj.6060/ref-44) 2016; 26 Wijtten (10.7717/peerj.6060/ref-49) 2011; 105 Watanabe (10.7717/peerj.6060/ref-47) 2010; 120 Wang (10.7717/peerj.6060/ref-45) 2009; 96 Laval (10.7717/peerj.6060/ref-13) 2015; 6 Rodgers (10.7717/peerj.6060/ref-34) 2013; 126 Bouskra (10.7717/peerj.6060/ref-5) 2008; 456 Opitz (10.7717/peerj.6060/ref-30) 2006; 176 Wu (10.7717/peerj.6060/ref-50) 2016; 172 Kobayashi (10.7717/peerj.6060/ref-9) 2002; 416 |
References_xml | – volume: 107 start-page: 883 year: 2015 ident: 10.7717/peerj.6060/ref-33 article-title: Effects of Lactobacillus acidophilus dietary supplementation on the performance, intestinal barrier function, rectal microflora and serum immune function in weaned piglets challenged with Escherichia coli lipopolysaccharide publication-title: Antonie van Leeuwenhoek doi: 10.1007/s10482-015-0380-z contributor: fullname: Qiao – volume: 8 start-page: 168 year: 2002 ident: 10.7717/peerj.6060/ref-16 article-title: Preventive effect of glutamine on intestinal barrier dysfunction induced by severe trauma publication-title: World Journal of Gastroenterology doi: 10.3748/wjg.v8.i1.168 contributor: fullname: Li – volume: 11 start-page: e0158865 year: 2016 ident: 10.7717/peerj.6060/ref-51 article-title: Regulation of thrombin-induced lung endothelial cell barrier disruption by protein kinase C delta publication-title: PLOS ONE doi: 10.1371/journal.pone.0158865 contributor: fullname: Xie – volume: 169 start-page: 1 year: 2017 ident: 10.7717/peerj.6060/ref-2 article-title: Acute social stress-induced immunomodulation in pigs high and low responders to ACTH publication-title: Physiology & Behavior doi: 10.1016/j.physbeh.2016.11.012 contributor: fullname: Bacou – volume: 85 start-page: 1504 year: 2013 ident: 10.7717/peerj.6060/ref-17 article-title: A novel benzo[d]imidazole derivate prevents the development of dextran sulfate sodium-induced murine experimental colitis via inhibition of NLRP3 inflammasome publication-title: Biochemical Pharmacology doi: 10.1016/j.bcp.2013.03.008 contributor: fullname: Liu – volume: 11 start-page: 1136 year: 2010 ident: 10.7717/peerj.6060/ref-29 article-title: Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria publication-title: Nature Immunology doi: 10.1038/ni.1960 contributor: fullname: Miao – volume: 32 start-page: 379 year: 2010 ident: 10.7717/peerj.6060/ref-54 article-title: The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis publication-title: Immunity doi: 10.1016/j.immuni.2010.03.003 contributor: fullname: Zaki – volume: 15 start-page: 32 year: 2015 ident: 10.7717/peerj.6060/ref-53 article-title: Lactobacillus reuteri I5007 modulates tight junction protein expression in IPEC-J2 cells with LPS stimulation and in newborn piglets under normal conditions publication-title: BMC Microbiology doi: 10.1186/s12866-015-0372-1 contributor: fullname: Yang – volume: 108 start-page: 4607 year: 2011 ident: 10.7717/peerj.6060/ref-48 article-title: Epithelial crosstalk at the microbiota-mucosal interface publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.1000092107 contributor: fullname: Wells – volume: 1165 start-page: 220 year: 2009 ident: 10.7717/peerj.6060/ref-10 article-title: Dynamic regulation of epithelial cell fate and barrier function by intercellular junction publication-title: Annals of the New York Academy of Sciences doi: 10.1111/j.1749-6632.2009.04025.x contributor: fullname: Koch – volume: 38 start-page: 1353 year: 2011 ident: 10.7717/peerj.6060/ref-20 article-title: Lactobacillus plantarum prevents the development of colitis in IL-10-deficient mouse by reducing the intestinal permeability publication-title: Molecular Biology Reports doi: 10.1007/s11033-010-0237-5 contributor: fullname: Liu – volume: 27 start-page: 111 year: 2015 ident: 10.7717/peerj.6060/ref-38 article-title: Mucosal physical and chemical innate barriers: lessons from microbial evasion strategies publication-title: Seminars in Immunology doi: 10.1016/j.smim.2015.03.011 contributor: fullname: Sperandio – volume: 105 start-page: 967 year: 2011 ident: 10.7717/peerj.6060/ref-49 article-title: Intestinal barrier function and absorption in pigs after weaning: a review publication-title: British Journal of Nutrition doi: 10.1017/S0007114510005660 contributor: fullname: Wijtten – volume: 9 start-page: 717 year: 2006 ident: 10.7717/peerj.6060/ref-52 article-title: Probiotics as functional food in the treatment of diarrhea publication-title: Current Opinion in Clinical Nutrition and Metabolic Care doi: 10.1097/01.mco.0000247477.02650.51 contributor: fullname: Yan – volume: 76 start-page: 1135 year: 2016 ident: 10.7717/peerj.6060/ref-1 article-title: Cdx2 expression and intestinal metaplasia induced by H. pylori infection of gastric cells is regulated by NOD1-mediated innate immune responses publication-title: Cancer Research doi: 10.1158/0008-5472.CAN-15-2272 contributor: fullname: Asano – volume: 2017 start-page: 6519785 year: 2017 ident: 10.7717/peerj.6060/ref-31 article-title: Gut microbiome and inflammation: a study of diabetic inflammasome-knockout mice publication-title: Journal of Diabetes Research doi: 10.1155/2017/6519785 contributor: fullname: Pahwa – volume: 30 start-page: 135 year: 2004 ident: 10.7717/peerj.6060/ref-32 article-title: Effects of enteral supplementation with glutamine granules on intestinal mucosal barrier function in severe burned patients publication-title: Burns doi: 10.1016/j.burns.2003.09.032 contributor: fullname: Peng – volume: 456 start-page: 507 year: 2008 ident: 10.7717/peerj.6060/ref-5 article-title: Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis publication-title: Nature doi: 10.1038/nature07450 contributor: fullname: Bouskra – volume: 62 start-page: 860 year: 2014 ident: 10.7717/peerj.6060/ref-21 article-title: Oral administration of Lactobacillus fermentum I5007 favors intestinal development and alters the intestinal microbiota in formula-fed piglets publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf403288r contributor: fullname: Liu – volume: 35 start-page: 8 year: 2017 ident: 10.7717/peerj.6060/ref-24 article-title: Homology modeling and in silico prediction of Ulcerative colitis associated polymorphisms of NOD1 publication-title: Molecular and Cellular Probes doi: 10.1016/j.mcp.2017.05.009 contributor: fullname: Majumdar – volume: 42 start-page: 94 year: 2016 ident: 10.7717/peerj.6060/ref-3 article-title: Tight junctions as regulators of tissue remodeling publication-title: Current Opinion in Cell Biology doi: 10.1016/j.ceb.2016.05.006 contributor: fullname: Balda – volume: 41 start-page: 1445 year: 2011 ident: 10.7717/peerj.6060/ref-23 article-title: Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands publication-title: European Journal of Immunology doi: 10.1002/eji.201040827 contributor: fullname: Magalhaes – volume: 90 start-page: 787 year: 2011 ident: 10.7717/peerj.6060/ref-27 article-title: A look at tricellulin and its role in tight junction formation and maintenance publication-title: European Journal of Cell Biology doi: 10.1016/j.ejcb.2011.06.005 contributor: fullname: Mariano – volume: 91 start-page: e00202–17 year: 2017 ident: 10.7717/peerj.6060/ref-22 article-title: Tight junction protein occludin is a porcine epidemic diarrhea virus entry factor publication-title: Journal of Virology doi: 10.1128/JVI.00202-17 contributor: fullname: Luo – volume: 53 start-page: 821 year: 2004 ident: 10.7717/peerj.6060/ref-28 article-title: Lactic acid bacteria secrete metabolites retaining anti-inflammatory properties after intestinal transport publication-title: Gut doi: 10.1136/gut.2003.026252 contributor: fullname: Ménard – volume: 187 start-page: 1301 year: 2017 ident: 10.7717/peerj.6060/ref-43 article-title: Tight junction proteins claudin-1 and occludin are important for cutaneous wound healing publication-title: The American Journal of Pathology doi: 10.1016/j.ajpath.2017.02.006 contributor: fullname: Volksdorf – volume: 58 start-page: 384 year: 2014 ident: 10.7717/peerj.6060/ref-46 article-title: Intestinal dysbacteriosis contributes to decreased intestinal mucosal barrier function and increased bacterial translocation publication-title: Letters in Applied Microbiology doi: 10.1111/lam.12201 contributor: fullname: Wang – volume: 53 start-page: 301 year: 2004 ident: 10.7717/peerj.6060/ref-11 article-title: Gut function and dysfunction in young pigs: physiology publication-title: Animal Research doi: 10.1051/animres:2004018 contributor: fullname: Lallès – volume: 126 start-page: 1565 year: 2013 ident: 10.7717/peerj.6060/ref-34 article-title: Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1 publication-title: Journal of Cell Science doi: 10.1242/jcs.113399 contributor: fullname: Rodgers – volume: 9 start-page: 559 year: 2017 ident: 10.7717/peerj.6060/ref-18 article-title: Lactobacillus reuteri I5007 modulates intestinal host defense peptide expression in the model of IPEC-J2 cells and neonatal piglets publication-title: Nutrients doi: 10.3390/nu9060559 contributor: fullname: Liu – volume: 172 start-page: 55 year: 2016 ident: 10.7717/peerj.6060/ref-50 article-title: Protective effects of Lactobacillus plantarum on epithelial barrier disruption caused by enterotoxigenic Escherichia coli in intestinal porcine epithelial cells publication-title: Veterinary Immunology and Immunopathology doi: 10.1016/j.vetimm.2016.03.005 contributor: fullname: Wu – volume: 176 start-page: 484 year: 2006 ident: 10.7717/peerj.6060/ref-30 article-title: Listeria monocytogenes activated p38 MAPK and induced IL-8 secretion in a nucleotide-binding oligomerization domain 1-dependent manner in endothelial cells publication-title: The Journal of Immunology doi: 10.4049/jimmunol.176.1.484 contributor: fullname: Opitz – volume: 80 start-page: 563 year: 2017 ident: 10.7717/peerj.6060/ref-36 article-title: Three months of Western diet induces small intestinal mucosa alteration in TLR KO mice publication-title: Microscopy Research & Technique doi: 10.1002/jemt.22831 contributor: fullname: Sardi – volume: 9 start-page: 799 year: 2009 ident: 10.7717/peerj.6060/ref-41 article-title: Intestinal mucosal barrier function in health and disease publication-title: Nature Reviews Immunology doi: 10.1038/nri2653 contributor: fullname: Turner – volume: 24 start-page: 3056 year: 2013 ident: 10.7717/peerj.6060/ref-6 article-title: Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux publication-title: Molecular Biology of the Cell doi: 10.1091/mbc.E12-09-0688 contributor: fullname: Buschmann – volume: 22 start-page: 577 year: 2016 ident: 10.7717/peerj.6060/ref-7 article-title: Asparagine improves intestinal integrity, inhibits TLR4 and NOD signaling, and differently regulates p38 and ERK1/2 signaling in weanling piglets after LPS challenge publication-title: Innate Immunity doi: 10.1177/1753425916664124 contributor: fullname: Chen – volume: 2 start-page: 285 year: 2001 ident: 10.7717/peerj.6060/ref-40 article-title: Multifunctional strands in tight junctions publication-title: Nature Reviews Molecular Cell Biology doi: 10.1038/35067088 contributor: fullname: Tsukita – volume: 6 start-page: 1 year: 2015 ident: 10.7717/peerj.6060/ref-13 article-title: Lactobacillus rhamnosus CNCM I-3690 and the commensal bacterium Faecalibacterium prausnitzii A2-165 exhibit similar protective effects to induced barrier hyper-permeability in mice publication-title: Gut Microbes doi: 10.4161/19490976.2014.990784 contributor: fullname: Laval – volume: 416 start-page: 194 year: 2002 ident: 10.7717/peerj.6060/ref-9 article-title: RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems publication-title: Nature doi: 10.1038/416194a contributor: fullname: Kobayashi – volume: 8 start-page: 1168 year: 2017 ident: 10.7717/peerj.6060/ref-14 article-title: Epithelial cell inflammasomes in intestinal immunity and inflammation publication-title: Frontiers in Immunology doi: 10.3389/fimmu.2017.01168 contributor: fullname: Lei-Leston – volume: 32 start-page: 367 year: 2010 ident: 10.7717/peerj.6060/ref-8 article-title: Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases publication-title: Immunity doi: 10.1016/j.immuni.2010.02.012 contributor: fullname: Dupaul-Chicoine – volume: 120 start-page: 1645 year: 2010 ident: 10.7717/peerj.6060/ref-47 article-title: NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway publication-title: The Journal of Clinical Investigation doi: 10.1172/JCI39481 contributor: fullname: Watanabe – volume: 26 start-page: 1018 year: 2016 ident: 10.7717/peerj.6060/ref-44 article-title: In Vitro evaluation of swine-derived Lactobacillus reuteri: probiotic properties and effects on intestinal porcine epithelial cells challenged with enterotoxigenic Escherichia coli K88 publication-title: Journal of Microbiology Biotechnology doi: 10.4014/jmb.1510.10089 contributor: fullname: Wang – volume: 59 start-page: 1192 year: 2010 ident: 10.7717/peerj.6060/ref-4 article-title: Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome publication-title: Gut doi: 10.1136/gut.2009.197822 contributor: fullname: Bauer – volume: 64 start-page: 1529 year: 2015 ident: 10.7717/peerj.6060/ref-39 article-title: Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice publication-title: Gut doi: 10.1136/gutjnl-2014-308419 contributor: fullname: Tanaka – volume: 96 start-page: 89 year: 2009 ident: 10.7717/peerj.6060/ref-45 article-title: Influence of Lactobacillus fermentum I5007 on the intestinal and systemic immune responses of healthy and E. coli challenged piglets publication-title: Antonie van Leeuwenhoek doi: 10.1007/s10482-009-9339-2 contributor: fullname: Wang – volume: 97 start-page: 1310 year: 2017 ident: 10.7717/peerj.6060/ref-12 article-title: Effects of Lactobacillus acidophilus supplementation on growth performance, nutrient digestibility, fecal microbial and noxious gas emission in weaning pigs publication-title: Journal of the Science of Food and Agriculture doi: 10.1002/jsfa.7866 contributor: fullname: Lan – volume: 11 start-page: e0146312 year: 2016 ident: 10.7717/peerj.6060/ref-26 article-title: Dietary Lactobacillus rhamnosus GG supplementation improves the mucosal barrier function in the intestine of weaned piglets challenged by porcine rotavirus publication-title: PLOS ONE doi: 10.1371/journal.pone.0146312 contributor: fullname: Mao – volume: 137 start-page: 2709 year: 2007 ident: 10.7717/peerj.6060/ref-35 article-title: The novel porcine Lactobacillus sobrius strain protects intestinal cells from enterotoxigenic Escherichia coli K88 infection and prevents membrane barrier damage publication-title: The Jounal of Nutrition doi: 10.1093/jn/137.12.2709 contributor: fullname: Roselli – volume: 7 start-page: 763 year: 2014 ident: 10.7717/peerj.6060/ref-37 article-title: Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen publication-title: Mucosal Immunology doi: 10.1038/mi.2013.94 contributor: fullname: Song-Zhao – volume: 3 start-page: e96322 year: 2018 ident: 10.7717/peerj.6060/ref-25 article-title: Nlrp3-dependent IL-1β inhibits CD103+ dendritic cell differentiation in the gut publication-title: JCI Insight doi: 10.1172/jci.insight.96322 contributor: fullname: Mak’Anyengo – volume: 7 start-page: 40418 year: 2017 ident: 10.7717/peerj.6060/ref-19 article-title: NF-κB activation is critical for bacterial lipoprotein tolerance-enhanced bactericidal activity in macrophages during microbial infection publication-title: Scientific Reports doi: 10.1038/srep40418 contributor: fullname: Liu – volume: 200 start-page: 86 year: 2015 ident: 10.7717/peerj.6060/ref-55 article-title: Effect of direct-fed microbial on growth performance, nutrient digestibility, fecal noxious gas emission, fecal microbial flora and diarrhea score in weanling pigs publication-title: Animal Feed Science and Technology doi: 10.1016/j.anifeedsci.2014.12.010 contributor: fullname: Zhao – volume: 6 start-page: 29142 year: 2016 ident: 10.7717/peerj.6060/ref-15 article-title: Zonulin regulates intestinal permeability and facilitates enteric bacteria permeation in coronary artery disease publication-title: Scientific Reports doi: 10.1038/srep29142 contributor: fullname: Li – volume: 73 start-page: 451 year: 1998 ident: 10.7717/peerj.6060/ref-42 article-title: D-lactic acidosis: pathologic consequence of saprophytism publication-title: Mayo Clinic Proceedings doi: 10.1016/S0025-6196(11)63729-4 contributor: fullname: Vella |
SSID | ssj0000826083 |
Score | 2.2486136 |
Snippet | supplementation is beneficial to the barrier function of the intestinal physical barrier in piglets. However, the mechanisms underlying this beneficial... Lactobacillus supplementation is beneficial to the barrier function of the intestinal physical barrier in piglets. However, the mechanisms underlying this... Lactobacillus supplementation is beneficial to the barrier function of the intestinal physical barrier in piglets. However, the mechanisms underlying this... |
SourceID | doaj pubmedcentral proquest gale crossref pubmed |
SourceType | Open Website Open Access Repository Aggregation Database Index Database |
StartPage | e6060 |
SubjectTerms | Agricultural Science Animal sciences Caspase-1 Cellular signal transduction Cytokines Dietary supplements E coli Gene expression Health aspects Hogs IL-1β Ileum Inflammation Interleukin 18 Intestinal physical barrier Intestine Jejunum Kinases Lactobacillus acidophilus Mammals Metabolism Molecular Biology Mucous membrane NF-κB protein NLRs NOD-like receptors Nod1 protein Nutrition Permeability Protein-serine/threonine kinase Proteins Pyrin protein Receptor mechanisms Signal transduction Swine Tumor necrosis factor-TNF Veterinary Medicine Weaned piglet Zoology |
SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQD4gL4k3aUoxA4tLQdWLHzrE8qgrRcqFSb5YfExpYZaPNroA_xu_rTJIuG3HgwimrePLyjL_5vB7PMPZKCDfLQMs0z0xIZcR5indFmQYPKquASAqt6J6dF6cX8uOlutwq9UUxYUN64KHjjnSIsQSdu0KDFKIoI2hRqUoGofNchR59hdqaTPUYjKwZycWQj1TjlOWoBVh-e4N0fTbxQH2i_r_heMsfTWMlt5zPyT12d2SN_Hh42_vsFjQP2O2zcV38Ifs9JCHu-KLisYaVW_7iHdXrHGLDqfM5_ePKP1F5He9CPZ-vO47HuGivavqNEsgFeftnI8Ehp1wSCAH06HbUJ_duSUXuODlEuu8hd03sL4WfY1BtQ69x_vl9Oq-_A0dIhZZq-uDt-A9wiOu8rb-ivXSP2MXJhy_vTtOxIkMalJ6t0qzKAiAByw2UogTpdMgLUVVGSa8iMh0vIno8F6SKKi8lqjsaRFCEDe2RmOWP2U6zaOAp4wYnx0FW2I6ULKM88vgIHWYefKwQhhL28kZLth0Sb1icsJAuba9LS7pM2FtS4EaCkmX3J9CE7GhC9l8mlLDnpH477DzdDHl7jFQX-V9pVMJe9xI06NEKghv3LuCnUPqsieT-RBIHa5g235iYHcGis8i6jJAauULCXmya6UoKgGtgsSYZ5LlUtj5L2JPBIjcfjZBtkOeWCdMTW530yrSlqa_6VOIFLVsbsfs_unGP3UE2aSjWR5h9trNaruEZMraVP-gH5zVGxEP2 priority: 102 providerName: Directory of Open Access Journals – databaseName: AUTh Library subscriptions: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9MwELZgE4gXBOVXYIARSLwsW504sfOENtg0IVYQYmjiJUrsyxaoktC0gr-Mv4-7xE0XIfHUKr6kTu_83Wf7fMfYKyGyaQBK-mGgjS8tzlPyLE58k0MUFEAkhXZ0T2fxyZl8fx6duwW31oVVrjGxA2pbG1oj30fXpIVUCKhvmp8-VY2i3VVXQuM62w6EpG3a7cOj2afPwyoLOrgYSUafl1Th1GW_AVh830PaPh15oi5h_7-wfMUvjWMmrzih4zvstmOP_KBX9112DaoJu3nq9scnbPKVolu6I7Z8c_XGt7pbPL_H_vTJilteF9yWsCS5lup69jHkpCROK7P8A5XhyTNTzuerluOnrZvLkr6jBHJG3mwOHOxyyjmBUEFda5zeeZ4tqBgeJ8dJz93lWWW7W-G3C76tqBuzj-_8efkDOEIvNFT7Bx_Hf0GG-M-b8gLtqr3Pzo6Pvrw98V3lBt9Earr0gyIwgEQt1JCIBGSmTBiLotCRzCOLjCgXFj1jZmRkozCRaBZWI9IivKgcCVz4gG1VdQWPGNc4iTaywHakbgHlm8efUGaaQ24LhCuPvVxrMW36BB0pTmxI12mn65R07bFDUvAgQUm1uwv14iJ1YzRVxtoEVJjFCqQQcWJBiSIqpBEqDCPjsedkHml_QnWAhvQAKTHyxERHHnvdSRA4oJWYzJ1xwFehNFsjyZ2RJA5qM25em2DqQKVNN0PAYy-GZrqTAuUqqFckg3yYytsHHnvYW-zw0gjtGvlw4jE1suXRvzJuqcrLLuV4TNvbWjz-f7eesFvIJzVF-wi9w7aWixU8Rc62zJ-5gfkXs4VHMg priority: 102 providerName: ProQuest – databaseName: Scholars Portal Journals: Open Access(OpenAccess) dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3db9MwELemISFeEOMzMMAIJF6WUid27Dyh8TFNiI4XKu0tcuzLFqiSkLba9o_x93GXpGUBJJ5a1eek8Z3vfhfbv2PslRB2GoGWYRwZF0qPeUpukzR0OaioAAIptKI7O0mO5_LTqTrdYZv6ncMALv-Z2lE9qXm7mFz-uHqLEx7x60RjNvKmAWi_TRCJY-p-I5KxJEufDTC_88iIoacdI2dENN8IOtKeqfSP7qPY1FH4_-2or0Wq8S7Ka2Hp6A67PeBJftgbwB7bgeouuzkbVszvsZ89PfGS1wX3Jaxse8WXVMmz3zVOauH0LpZ_psI7uXXlYrFecvz0dXNe0neUQJTIm99HDA44sUygc6BbN4OmeW5bKn_HKVTSdQ-4rXzXFS6H7bYV_Y2TLx_CRfkdODpbaKjaD16OX4BFj8-b8gwtaXmfzY8-fn1_HA61GkKn9HQVRkXkAKFZbCAVKUirXZyIojBK5sojBsqFx1honVRexalEQ_AGfSs6FJ0jZIsfsN2qruAR4wbTZicLbEewFhHDPN5Cu2kOuS_QQQXs5UZLWdNTcmSYypAus06XGekyYO9IgVsJotHufqjbs2yYlZl23qegY5tokEIkqQctClVIJ3QcKxew56T-rD-TunUG2SGCYESGqVEBe91JkIGiFTg7nGrARyFirZHk_kgSp7EbN29MLNvMggzxmBFSI4oI2IttM_WkrXEV1GuSQQRMBe2jgD3sLXL70OjMDSLgNGB6ZKujURm3VOV5RzKe0IK2EY__OwJP2C0EkYa2-Aizz3ZX7RqeIlBb5c-6WfgLTdJAxA priority: 102 providerName: Scholars Portal |
Title | Effects of dietary supplementation with Lactobacillus acidophilus on the performance, intestinal physical barrier function, and the expression of NOD-like receptors in weaned piglets |
URI | https://www.ncbi.nlm.nih.gov/pubmed/30588399 https://www.proquest.com/docview/2158147801 https://search.proquest.com/docview/2161065152 https://pubmed.ncbi.nlm.nih.gov/PMC6302781 https://doaj.org/article/7cdd9e73a67e41169de71f5f4c17335c |
Volume | 6 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELe2ISFeEJSvwChGIPGytHXixM7jNjYmRMuEGOpbFH9kC3RJ1A_BX8bfx52TlEa88ZJG8Tl1cueff47Pd4S8ZSybBFZwPwyk9rmBeYrK4sTXykZBbpGk4IrudBZfXPGP82i-R6JuL4xz2teqGJWL21FZ3DjfyvpWjzs_sfHl9DTGxTbJxvtkX4ThzhTdwS8QZuAVTShSAbOVcW3t8vsImDqmfQP7lkAKkt445ML1_wvKO6NS32NyZwg6f0Dut9yRHjdtfEj2bDkgd6ft6viADL6hb4vbYEu7q4_I7yZA8YpWOTWFXWPpCnN5Nn7jqBiKX2PpJ0y9ozJdLBabFYVfU9U3BZ6DBPBEWv_dZHBEMc4EwAM2qG51TVW2xAR4FAdLvO8RzUrjqtpfrcNtic2YfX7vL4oflgLc2hrz_cDt6E-bAebTurgGW1o9JlfnZ19PL_w2W4OvIzFZ-0EeaAvkLJQ2YYnlmdBhzPJcRlxFBliQYgZGw0zzyERhwsEUjAR0BUgRCkhb-IQclFVpnxEqYeKseQ7lQNcCjDEPfyH0RFllcoAoj7zpdJfWTVCOFCYzqOzUKTtFZXvkBNW6lcBA2u5CtbxOW3NKhTYmsSLMYmE5Y3FirGB5lHPNwLQi7ZFXaBRpsyt1CwfpMdBg4IaJjDzyzkkgIIBt6Kzd1wCPgqG1epKHPUnoyLpf3Ble2gLJKgVGJhkXwCM88npbjDXROa601QZlgANjSvvAI08bO90-dGfuHhE9C-69lX4J9DoXZrztZc__u-YLcg_opUTnHyYPycF6ubEvgcKt1ZDcOTmbXX4Zuk8gcPwwZ3Cccjl0nfkPn8RQIQ |
link.rule.ids | 230,315,733,786,790,870,891,2115,21416,24346,27955,27956,33777,33778,43838,53825,53827,74657 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELegEx8vCMpXYDAjkHhZWJ04sfOENthUoCsIbdPEi5XYzhaoktC0gr-Mv4-7xG0XIfHUKr6kTu_8u5_t8x0hrxhLR4EV3A8DqX1uYJ6SpXHi68xGQW6RpOCO7vE0Hp_yj-fRuVtwa1xY5QoTW6A2lcY18j1wTZJxAYD6tv7pY9Uo3F11JTSuky1MuSkHZOvgcPrl63qVBRxcDCSjy0sqYOqyV1s7__4GaPuo54nahP3_wvIVv9SPmbzihI7ukjuOPdL9Tt33yDVbDsnNY7c_PiTDM4xuaY_Y0s3VG9-qdvH8PvnTJStuaJVTU9gFyjVY17OLIUclUVyZpRMsw5OlupjNlg2FT1PVlwV-BwngjLTeHDjYpZhzAqACu1Y7vdMsnWMxPIqOE5-7S9PStLfa3y74tsRuTD-_92fFD0sBem2NtX_gcfSXTQH_aV1cgF01D8jp0eHJu7HvKjf4OhKjhR_kgbZA1EJpE5ZYngodxizPZcSzyAAjypgBz5hqHpkoTDiYhZGAtAAvIgMCFz4kg7Iq7WNCJUyiNc-hHahbgPnm4SeEHmU2MznAlUderrSo6i5Bh4KJDepatbpWqGuPHKCC1xKYVLu9UM0vlBujSmhjEivCNBaWMxYnxgqWRznXTIRhpD2yg-ahuhOqa2hQ-0CJgScmMvLI61YCwQGsRKfujAO8CqbZ6klu9yRhUOt-88oElQOVRm2GgEderJvxTgyUK221RBngw1jePvDIo85i1y8N0C6BDyceET1b7v0r_ZayuGxTjse4vS3Zk_93a4fcGp8cT9Tkw_TTU3IbuKXEyB8mt8lgMV_aZ8DfFtlzN0j_AlVPSig |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9MwELZgExMvCMqvjMGMQOJloXXixM4T2tiqAVuZEEMTL1ZiO1tYlYSmFfxl_H3cJW67CImnVvEldXrn7z7b5ztCXjOWjgIruB8GUvvcwDwlS-PE15mNgtwiScEd3dNJfHzOP15EFy7-qXFhlUtMbIHaVBrXyIfgmiTjAgB1mLuwiLPD8bv6p48VpHCn1ZXTuE02BY8jmIhtHhxNzr6sVlzA2cVAOLocpQKmMcPa2tmPt0DhRz2v1Cbv_xeib_iofvzkDYc0vk_uOSZJ9zvVPyC3bDkgW6dur3xABt8w0qU9bkvXV-98r9qF9IfkT5e4uKFVTk1h5yjXYI3PLp4cFUZxlZaeYEmeLNXFdLpoKHyaqr4q8DtIAH-k9frwwR7F_BMAG9i12tkAzdIZFsaj6ETxuXs0LU17q_3tAnFL7Mbk86E_La4tBRi2NdYBgsfRXzYFX0Dr4hJsrHlEzsdHX98f-66Kg68jMZr7QR5oC6QtlDZhieWp0GHM8lxGPIsMsKOMGfCSqeaRicKEg4kYCagLUCMyIHPhY7JRVqV9SqiECbXmObQDjQsw9zz8hNCjzGYmB-jyyKulFlXdJetQMMlBXatW1wp17ZEDVPBKAhNstxeq2aVy41UJbUxiRZjGwnLG4sRYwfIo55qJMIy0R3bRPFR3WnUFE2of6DFwxkRGHnnTSiBQgJXo1J13gFfBlFs9yZ2eJAxw3W9emqByANOo9XDwyMtVM96JQXOlrRYoA9wYS90HHnnSWezqpQHmJXDjxCOiZ8u9f6XfUhZXbfrxGLe6Jdv-f7d2yRaMT3XyYfLpGbkLNFNiEBCTO2RjPlvY50Dl5tkLN0b_AqhFTlw |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effects+of+dietary+supplementation+with+Lactobacillus+acidophilus+on+the+performance%2C+intestinal+physical+barrier+function%2C+and+the+expression+of+NOD-like+receptors+in+weaned+piglets&rft.jtitle=PeerJ+%28San+Francisco%2C+CA%29&rft.au=Li%2C+Haihua&rft.au=Du%2C+Chenhong&rft.au=Yang%2C+Dongji&rft.au=Zhu%2C+Qi&rft.date=2018-12-18&rft.pub=PeerJ.+Ltd&rft.issn=2167-8359&rft.eissn=2167-8359&rft.volume=6&rft.spage=e6060&rft_id=info:doi/10.7717%2Fpeerj.6060&rft.externalDBID=n%2Fa&rft.externalDocID=A566125985 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2167-8359&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2167-8359&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2167-8359&client=summon |