TNF-α induces human neural progenitor cell survival after oxygen–glucose deprivation by activating the NF-κB pathway
Neural progenitor cell (NPC) transplantation has been shown to be beneficial in the ischemic brain. However, the low survival rate of transplanted NPCs in an ischemic microenvironment limits their therapeutic effects. Tumor necrosis factor-alpha (TNF-α) is one of the proinflammatory cytokines involv...
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| Published in | Experimental & molecular medicine Vol. 50; no. 4; pp. 1 - 14 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
06.04.2018
Springer Nature B.V Nature Publishing Group 생화학분자생물학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1226-3613 2092-6413 2092-6413 |
| DOI | 10.1038/s12276-018-0033-1 |
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| Abstract | Neural progenitor cell (NPC) transplantation has been shown to be beneficial in the ischemic brain. However, the low survival rate of transplanted NPCs in an ischemic microenvironment limits their therapeutic effects. Tumor necrosis factor-alpha (TNF-α) is one of the proinflammatory cytokines involved in the pathogenesis of various injuries. On the other hand, several studies have shown that TNF-α influences the proliferation, survival, and differentiation of NPCs. Our study investigated the effect of TNF-α pretreatment on human NPCs (hNPCs) under ischemia-related conditions in vitro. hNPCs harvested from fetal brain tissue were pretreated with TNF-α before being subjected to oxygen–glucose deprivation (OGD) to mimic ischemia in vitro. TNF-α pretreatment improved the viability and reduced the apoptosis of hNPCs after OGD. At the molecular level, TNF-α markedly increased the level of NF-κB signaling in hNPCs, and an NF-κB pathway inhibitor, BAY11-7082, completely reversed the protective effects of TNF-α on hNPCs. These results suggest that TNF-α improves hNPC survival by activating the NF-κB pathway. In addition, TNF-α significantly enhanced the expression of cellular inhibitor of apoptosis 2 (cIAP2). Use of a lentivirus-mediated short hairpin RNA targeting cIAP2 mRNA demonstrated that cIAP2 protected against OGD-induced cytotoxicity in hNPCs. Our study of intracellular NF-κB signaling revealed that inhibition of NF-κB activity abolished the TNF-α-mediated upregulation of cIAP2 in hNPCs and blocked TNF-α-induced cytoprotection against OGD. Therefore, this study suggests that TNF-α pretreatment, which protects hNPCs from OGD-induced apoptosis by activating the NF-κB pathway, provides a safe and simple approach to improve the viability of transplanted hNPCs in cerebral ischemia.
Stroke: creating a safe haven for neurological repair
A potent “survival signal” for brain stem cells could enable effective regenerative therapies for stroke patients. Neural progenitor cells (NPCs) can develop into functional neurons and supportive glial cells, and researchers are tantalized by the prospect of using NPCs to repair damaged brain tissue. NPCs generally fail to flourish after transplantation, but a team led by Kook In Park at Yonsei University College of Medicine, South Korea, have found a signaling factor that helps these cells to survive and divide. Tumor necrosis factor-α (TNF-α) is associated with inflammation, but also protects neurons after a stroke. The researchers showed that pretreatment with TNF-α preserved NPCs exposed to starvation and oxygen-deprivation conditions in cell culture by activating critical cell survival pathways. These findings suggest that TNF-α may enable NPCs to survive long enough to repair post-stroke neurological damage. |
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| AbstractList | Neural progenitor cell (NPC) transplantation has been shown to be beneficial in the ischemic brain. However, the low survival rate of transplanted NPCs in an ischemic microenvironment limits their therapeutic effects. Tumor necrosis factor-alpha (TNF-α) is one of the proinflammatory cytokines involved in the pathogenesis of various injuries. On the other hand, several studies have shown that TNF-α influences the proliferation, survival, and differentiation of NPCs. Our study investigated the effect of TNF-α pretreatment on human NPCs (hNPCs) under ischemia-related conditions in vitro. hNPCs harvested from fetal brain tissue were pretreated with TNF-α before being subjected to oxygen–glucose deprivation (OGD) to mimic ischemia in vitro. TNF-α pretreatment improved the viability and reduced the apoptosis of hNPCs after OGD. At the molecular level, TNF-α markedly increased the level of NF-κB signaling in hNPCs, and an NF-κB pathway inhibitor, BAY11-7082, completely reversed the protective effects of TNF-α on hNPCs. These results suggest that TNF-α improves hNPC survival by activating the NF-κB pathway. In addition, TNF-α significantly enhanced the expression of cellular inhibitor of apoptosis 2 (cIAP2). Use of a lentivirus-mediated short hairpin RNA targeting cIAP2 mRNA demonstrated that cIAP2 protected against OGD-induced cytotoxicity in hNPCs. Our study of intracellular NF-κB signaling revealed that inhibition of NF-κB activity abolished the TNF-α-mediated upregulation of cIAP2 in hNPCs and blocked TNF-α-induced cytoprotection against OGD. Therefore, this study suggests that TNF-α pretreatment, which protects hNPCs from OGD-induced apoptosis by activating the NF-κB pathway, provides a safe and simple approach to improve the viability of transplanted hNPCs in cerebral ischemia.
A potent “survival signal” for brain stem cells could enable effective regenerative therapies for stroke patients. Neural progenitor cells (NPCs) can develop into functional neurons and supportive glial cells, and researchers are tantalized by the prospect of using NPCs to repair damaged brain tissue. NPCs generally fail to flourish after transplantation, but a team led by Kook In Park at Yonsei University College of Medicine, South Korea, have found a signaling factor that helps these cells to survive and divide. Tumor necrosis factor-α (TNF-α) is associated with inflammation, but also protects neurons after a stroke. The researchers showed that pretreatment with TNF-α preserved NPCs exposed to starvation and oxygen-deprivation conditions in cell culture by activating critical cell survival pathways. These findings suggest that TNF-α may enable NPCs to survive long enough to repair post-stroke neurological damage. Neural progenitor cell (NPC) transplantation has been shown to be beneficial in the ischemic brain. However, the low survival rate of transplanted NPCs in an ischemic microenvironment limits their therapeutic effects. Tumor necrosis factor-alpha (TNF-α) is one of the proinflammatory cytokines involved in the pathogenesis of various injuries. On the other hand, several studies have shown that TNF-α influences the proliferation, survival, and differentiation of NPCs. Our study investigated the effect of TNF-α pretreatment on human NPCs (hNPCs) under ischemia-related conditions in vitro. hNPCs harvested from fetal brain tissue were pretreated with TNF-α before being subjected to oxygen–glucose deprivation (OGD) to mimic ischemia in vitro. TNF-α pretreatment improved the viability and reduced the apoptosis of hNPCs after OGD. At the molecular level, TNF-α markedly increased the level of NF-κB signaling in hNPCs, and an NF-κB pathway inhibitor, BAY11-7082, completely reversed the protective effects of TNF-α on hNPCs. These results suggest that TNF-α improves hNPC survival by activating the NF-κB pathway. In addition, TNF-α significantly enhanced the expression of cellular inhibitor of apoptosis 2 (cIAP2). Use of a lentivirus-mediated short hairpin RNA targeting cIAP2 mRNA demonstrated that cIAP2 protected against OGD-induced cytotoxicity in hNPCs. Our study of intracellular NF-κB signaling revealed that inhibition of NF-κB activity abolished the TNF-α-mediated upregulation of cIAP2 in hNPCs and blocked TNF-α-induced cytoprotection against OGD. Therefore, this study suggests that TNF-α pretreatment, which protects hNPCs from OGD-induced apoptosis by activating the NF-κB pathway, provides a safe and simple approach to improve the viability of transplanted hNPCs in cerebral ischemia. Neural progenitor cell (NPC) transplantation has been shown to be beneficial in the ischemic brain. However, the low survival rate of transplanted NPCs in an ischemic microenvironment limits their therapeutic effects. Tumor necrosis factor-alpha (TNF-α) is one of the proinflammatory cytokines involved in the pathogenesis of various injuries. On the other hand, several studies have shown that TNF-α influences the proliferation, survival, and differentiation of NPCs. Our study investigated the effect of TNF-α pretreatment on human NPCs (hNPCs) under ischemia-related conditions in vitro. hNPCs harvested from fetal brain tissue were pretreated with TNF-α before being subjected to oxygen–glucose deprivation (OGD) to mimic ischemia in vitro. TNF-α pretreatment improved the viability and reduced the apoptosis of hNPCs after OGD. At the molecular level, TNF-α markedly increased the level of NF-κB signaling in hNPCs, and an NF-κB pathway inhibitor, BAY11-7082, completely reversed the protective effects of TNF-α on hNPCs. These results suggest that TNF-α improves hNPC survival by activating the NF-κB pathway. In addition, TNF-α significantly enhanced the expression of cellular inhibitor of apoptosis 2 (cIAP2). Use of a lentivirus-mediated short hairpin RNA targeting cIAP2 mRNA demonstrated that cIAP2 protected against OGD-induced cytotoxicity in hNPCs. Our study of intracellular NF-κB signaling revealed that inhibition of NF-κB activity abolished the TNF-α-mediated upregulation of cIAP2 in hNPCs and blocked TNF-α-induced cytoprotection against OGD. Therefore, this study suggests that TNF-α pretreatment, which protects hNPCs from OGD-induced apoptosis by activating the NF-κB pathway, provides a safe and simple approach to improve the viability of transplanted hNPCs in cerebral ischemia. Stroke: creating a safe haven for neurological repair A potent “survival signal” for brain stem cells could enable effective regenerative therapies for stroke patients. Neural progenitor cells (NPCs) can develop into functional neurons and supportive glial cells, and researchers are tantalized by the prospect of using NPCs to repair damaged brain tissue. NPCs generally fail to flourish after transplantation, but a team led by Kook In Park at Yonsei University College of Medicine, South Korea, have found a signaling factor that helps these cells to survive and divide. Tumor necrosis factor-α (TNF-α) is associated with inflammation, but also protects neurons after a stroke. The researchers showed that pretreatment with TNF-α preserved NPCs exposed to starvation and oxygen-deprivation conditions in cell culture by activating critical cell survival pathways. These findings suggest that TNF-α may enable NPCs to survive long enough to repair post-stroke neurological damage. Neural progenitor cell (NPC) transplantation has been shown to be beneficial in the ischemic brain. However, the low survival rate of transplanted NPCs in an ischemic microenvironment limits their therapeutic effects. Tumor necrosis factor-alpha (TNF-α) is one of the proinflammatory cytokines involved in the pathogenesis of various injuries. On the other hand, several studies have shown that TNF-α influences the proliferation, survival, and differentiation of NPCs. Our study investigated the effect of TNF-α pretreatment on human NPCs (hNPCs) under ischemia-related conditions in vitro. hNPCs harvested from fetal brain tissue were pretreated with TNF-α before being subjected to oxygen-glucose deprivation (OGD) to mimic ischemia in vitro. TNF-α pretreatment improved the viability and reduced the apoptosis of hNPCs after OGD. At the molecular level, TNF-α markedly increased the level of NF-κB signaling in hNPCs, and an NF-κB pathway inhibitor, BAY11-7082, completely reversed the protective effects of TNF-α on hNPCs. These results suggest that TNF-α improves hNPC survival by activating the NF-κB pathway. In addition, TNF-α significantly enhanced the expression of cellular inhibitor of apoptosis 2 (cIAP2). Use of a lentivirus-mediated short hairpin RNA targeting cIAP2 mRNA demonstrated that cIAP2 protected against OGD-induced cytotoxicity in hNPCs. Our study of intracellular NF-κB signaling revealed that inhibition of NF-κB activity abolished the TNF-α-mediated upregulation of cIAP2 in hNPCs and blocked TNF-α-induced cytoprotection against OGD. Therefore, this study suggests that TNF-α pretreatment, which protects hNPCs from OGD-induced apoptosis by activating the NF-κB pathway, provides a safe and simple approach to improve the viability of transplanted hNPCs in cerebral ischemia.Neural progenitor cell (NPC) transplantation has been shown to be beneficial in the ischemic brain. However, the low survival rate of transplanted NPCs in an ischemic microenvironment limits their therapeutic effects. Tumor necrosis factor-alpha (TNF-α) is one of the proinflammatory cytokines involved in the pathogenesis of various injuries. On the other hand, several studies have shown that TNF-α influences the proliferation, survival, and differentiation of NPCs. Our study investigated the effect of TNF-α pretreatment on human NPCs (hNPCs) under ischemia-related conditions in vitro. hNPCs harvested from fetal brain tissue were pretreated with TNF-α before being subjected to oxygen-glucose deprivation (OGD) to mimic ischemia in vitro. TNF-α pretreatment improved the viability and reduced the apoptosis of hNPCs after OGD. At the molecular level, TNF-α markedly increased the level of NF-κB signaling in hNPCs, and an NF-κB pathway inhibitor, BAY11-7082, completely reversed the protective effects of TNF-α on hNPCs. These results suggest that TNF-α improves hNPC survival by activating the NF-κB pathway. In addition, TNF-α significantly enhanced the expression of cellular inhibitor of apoptosis 2 (cIAP2). Use of a lentivirus-mediated short hairpin RNA targeting cIAP2 mRNA demonstrated that cIAP2 protected against OGD-induced cytotoxicity in hNPCs. Our study of intracellular NF-κB signaling revealed that inhibition of NF-κB activity abolished the TNF-α-mediated upregulation of cIAP2 in hNPCs and blocked TNF-α-induced cytoprotection against OGD. Therefore, this study suggests that TNF-α pretreatment, which protects hNPCs from OGD-induced apoptosis by activating the NF-κB pathway, provides a safe and simple approach to improve the viability of transplanted hNPCs in cerebral ischemia. Neural progenitor cell (NPC) transplantation has been shown to be beneficial in the ischemic brain. However, the low survival rate of transplanted NPCs in an ischemic microenvironment limits their therapeutic effects. Tumor necrosis factor-alpha (TNF-α) is one of the proinflammatory cytokines involved in the pathogenesis of various injuries. On the other hand, several studies have shown that TNF-α influences the proliferation, survival, and differentiation of NPCs. Our study investigated the effect of TNF-α pretreatment on human NPCs (hNPCs) under ischemia-related conditions in vitro. hNPCs harvested from fetal brain tissue were pretreated with TNF-α before being subjected to oxygen–glucose deprivation (OGD) to mimic ischemia in vitro. TNF-α pretreatment improved the viability and reduced the apoptosis of hNPCs after OGD. At the molecular level, TNF-α markedly increased the level of NF-κB signaling in hNPCs, and an NF-κB pathway inhibitor, BAY11-7082, completely reversed the protective effects of TNF-α on hNPCs. These results suggest that TNF-α improves hNPC survival by activating the NF-κB pathway. In addition, TNF-α significantly enhanced the expression of cellular inhibitor of apoptosis 2 (cIAP2). Use of a lentivirus-mediated short hairpin RNA targeting cIAP2 mRNA demonstrated that cIAP2 protected against OGD-induced cytotoxicity in hNPCs. Our study of intracellular NF-κB signaling revealed that inhibition of NF-κB activity abolished the TNF-α-mediated upregulation of cIAP2 in hNPCs and blocked TNF-α-induced cytoprotection against OGD. Therefore, this study suggests that TNF-α pretreatment, which protects hNPCs from OGD-induced apoptosis by activating the NF-κB pathway, provides a safe and simple approach to improve the viability of transplanted hNPCs in cerebral ischemia. KCI Citation Count: 7 Stroke: creating a safe haven for neurological repair A potent “survival signal” for brain stem cells could enable effective regenerative therapies for stroke patients. Neural progenitor cells (NPCs) can develop into functional neurons and supportive glial cells, and researchers are tantalized by the prospect of using NPCs to repair damaged brain tissue. NPCs generally fail to flourish after transplantation, but a team led by Kook In Park at Yonsei University College of Medicine, South Korea, have found a signaling factor that helps these cells to survive and divide. Tumor necrosis factor-α (TNF-α) is associated with inflammation, but also protects neurons after a stroke. The researchers showed that pretreatment with TNF-α preserved NPCs exposed to starvation and oxygen-deprivation conditions in cell culture by activating critical cell survival pathways. These findings suggest that TNF-α may enable NPCs to survive long enough to repair post-stroke neurological damage. |
| Author | Kim, Il-Sun Shin, Jeong Eun Ko, Younhee Lee, Il-Shin Park, Kook In Jung, Kwangsoo Kim, Miri |
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| Cites_doi | 10.4049/jimmunol.165.4.1743 10.1371/journal.pone.0005586 10.1371/journal.pone.0050783 10.1038/376167a0 10.1016/j.nbd.2009.10.003 10.1006/exnr.1999.7098 10.1038/35102174 10.1002/glia.20665 10.1006/excr.1994.1296 10.1093/brain/awr094 10.1016/j.bbadis.2009.12.009 10.1634/stemcells.2007-0914 10.1002/stem.161 10.1093/brain/aws259 10.1016/j.trsl.2016.12.010 10.1016/S0092-8674(00)00116-1 10.1016/j.neuron.2011.05.005 10.1097/01.CCM.0000191714.39495.A6 10.1002/bies.10204 10.1016/S0168-8278(02)00063-6 10.1038/nm1202-1363 10.1038/sj.cdd.4401189 10.1016/S0165-0270(98)00126-5 10.1038/sj.onc.1203238 10.1016/S0092-8674(03)00521-X 10.1161/STROKEAHA.112.656900 10.1093/bioinformatics/btp120 10.1016/S0955-0674(98)80143-9 10.1111/j.1442-200X.2010.03266.x 10.1101/gad.13.3.239 10.1038/nmeth.1923 10.1016/j.expneurol.2006.03.015 10.1002/jnr.20531 10.1016/S0092-8674(03)00757-8 10.1074/jbc.M111.323709 10.1126/science.288.5467.870 10.1167/iovs.01-1201 10.1523/JNEUROSCI.13-08-03510.1993 10.1146/annurev.neuro.051508.135600 10.1038/379349a0 10.1038/nprot.2012.016 10.1002/jnr.1228 10.1093/brain/awl207 10.1038/jcbfm.2010.81 10.1111/j.1460-9568.2008.06599.x 10.1073/pnas.97.26.14720 10.1016/j.neures.2011.05.019 10.1196/annals.1332.018 10.1128/MCB.26.2.699-708.2006 10.1002/jcp.20881 10.3727/096368914X679354 10.1152/ajpgi.00422.2005 10.1523/JNEUROSCI.5475-03.2004 10.1523/JNEUROSCI.4032-05.2006 10.1126/science.274.5288.784 10.1023/A:1026465926478 10.1158/0008-5472.CAN-04-1918 |
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| References | Sakata (CR15) 2012; 135 Uchida (CR26) 2000; 97 Bliss, Andres, Steinberg (CR5) 2010; 37 Deveraux, Reed (CR53) 1999; 13 Lee, Jung, Kim, Park (CR4) 2010; 52 Polunovsky, Wendt, Ingbar, Peterson, Bitterman (CR37) 1994; 214 Liston, Young, Mackenzie, Korneluk (CR51) 1997; 2 Conte (CR54) 2006; 26 Piper (CR27) 2001; 66 Alexander, Acott (CR43) 2003; 44 Deng, Ren, Yang, Lin, Wu (CR44) 2003; 115 Schimmer (CR52) 2004; 64 Kim (CR28) 2006; 199 Wang, Mayo, Baldwin (CR38) 1996; 274 Lee (CR12) 2017; 183 Gutierrez-Uzquiza, Arechederra, Bragado, Aguirre-Ghiso, Porras (CR49) 2012; 287 Khoshnan (CR48) 2000; 165 Trapnell, Pachter, Salzberg (CR31) 2009; 25 Wang (CR14) 2011; 71 Kriegstein, Alvarez-Buylla (CR3) 2009; 32 Andres (CR6) 2011; 134 Cuschieri, Maier (CR24) 2005; 33 Trapnell (CR33) 2012; 7 Tournier (CR41) 2000; 288 Hallenbeck (CR17) 2002; 8 Wajant, Pfizenmaier, Scheurich (CR23) 2003; 10 Liu (CR10) 2006; 129 Furusu, Nakayama, Xu, Konta, Kitamura (CR57) 2007; 210 Temple (CR2) 2001; 414 Lee, Kim, Kim, Kim (CR11) 2009; 4 Sakata (CR13) 2012; 43 Carpenter (CR29) 1999; 158 Rosenblum (CR16) 2015; 24 Hicks (CR8) 2009; 29 Lan (CR22) 2012; 7 Cacci, Claasen, Kokaia (CR35) 2005; 80 Breunig, Haydar, Rakic (CR1) 2011; 70 Darsalia (CR7) 2011; 31 Ip, Davis (CR40) 1998; 10 Tanaka (CR55) 2004; 24 Bernardino (CR20) 2008; 26 Goldberg, Choi (CR30) 1993; 13 Langmead, Salzberg (CR32) 2012; 9 Greig (CR34) 2004; 1035 Micheau, Tschopp (CR36) 2003; 114 Liston (CR50) 1996; 379 Kim, Choi (CR42) 2010; 1802 Schwabe, Brenner (CR18) 2006; 290 Lin (CR45) 2003; 25 Schoemaker (CR56) 2002; 36 Svendsen (CR25) 1998; 85 Peng (CR21) 2008; 56 Turrin, Rivest (CR19) 2006; 26 Beg, Sha, Bronson, Ghosh, Baltimore (CR47) 1995; 376 Barkett, Gilmore (CR46) 1999; 18 Davis (CR39) 2000; 103 Nakagomi (CR9) 2009; 27 F Wang (33_CR14) 2011; 71 TM Bliss (33_CR5) 2010; 37 RF Schwabe (33_CR18) 2006; 290 A Lin (33_CR45) 2003; 25 E Cacci (33_CR35) 2005; 80 C Tournier (33_CR41) 2000; 288 VA Polunovsky (33_CR37) 1994; 214 P Liston (33_CR50) 1996; 379 H Liu (33_CR10) 2006; 129 JP Alexander (33_CR43) 2003; 44 P Liston (33_CR51) 1997; 2 HT Kim (33_CR28) 2006; 199 A Khoshnan (33_CR48) 2000; 165 RH Andres (33_CR6) 2011; 134 HJ Lee (33_CR11) 2009; 4 X Lan (33_CR22) 2012; 7 J Cuschieri (33_CR24) 2005; 33 A Furusu (33_CR57) 2007; 210 N Nakagomi (33_CR9) 2009; 27 N Uchida (33_CR26) 2000; 97 MK Carpenter (33_CR29) 1999; 158 NP Turrin (33_CR19) 2006; 26 H Sakata (33_CR13) 2012; 43 D Conte (33_CR54) 2006; 26 CN Svendsen (33_CR25) 1998; 85 C Trapnell (33_CR33) 2012; 7 A Gutierrez-Uzquiza (33_CR49) 2012; 287 YT Ip (33_CR40) 1998; 10 CY Wang (33_CR38) 1996; 274 MP Goldberg (33_CR30) 1993; 13 NH Greig (33_CR34) 2004; 1035 H Sakata (33_CR15) 2012; 135 L Bernardino (33_CR20) 2008; 26 IS Lee (33_CR12) 2017; 183 H Peng (33_CR21) 2008; 56 IS Lee (33_CR4) 2010; 52 V Darsalia (33_CR7) 2011; 31 JJ Breunig (33_CR1) 2011; 70 AD Schimmer (33_CR52) 2004; 64 O Micheau (33_CR36) 2003; 114 M Barkett (33_CR46) 1999; 18 AU Hicks (33_CR8) 2009; 29 JM Hallenbeck (33_CR17) 2002; 8 RJ Davis (33_CR39) 2000; 103 AA Beg (33_CR47) 1995; 376 EK Kim (33_CR42) 2010; 1802 DR Piper (33_CR27) 2001; 66 S Temple (33_CR2) 2001; 414 H Wajant (33_CR23) 2003; 10 H Tanaka (33_CR55) 2004; 24 MH Schoemaker (33_CR56) 2002; 36 A Kriegstein (33_CR3) 2009; 32 C Trapnell (33_CR31) 2009; 25 Y Deng (33_CR44) 2003; 115 B Langmead (33_CR32) 2012; 9 S Rosenblum (33_CR16) 2015; 24 QL Deveraux (33_CR53) 1999; 13 |
| References_xml | – volume: 70 start-page: 614 year: 2011 end-page: 625 ident: CR1 article-title: Neural stem cells: historical perspective and future prospects publication-title: Neuron – volume: 114 start-page: 181 year: 2003 end-page: 190 ident: CR36 article-title: Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes publication-title: Cell – volume: 10 start-page: 45 year: 2003 end-page: 65 ident: CR23 article-title: Tumor necrosis factor signaling publication-title: Cell Death Differ. – volume: 33 start-page: S417 year: 2005 end-page: S419 ident: CR24 article-title: Mitogen-activated protein kinase (MAPK) publication-title: Crit. Care Med. – volume: 44 start-page: 164 year: 2003 end-page: 169 ident: CR43 article-title: Involvement of the Erk-MAP kinase pathway in TNFalpha regulation of trabecular matrix metalloproteinases and TIMPs publication-title: Invest. Ophthalmol. Vis. Sci. – volume: 103 start-page: 239 year: 2000 end-page: 252 ident: CR39 article-title: Signal transduction by the JNK group of MAP kinases publication-title: Cell – volume: 158 start-page: 265 year: 1999 end-page: 278 ident: CR29 article-title: In vitro expansion of a multipotent population of human neural progenitor cells publication-title: Exp. Neurol. – volume: 24 start-page: 2750 year: 2004 end-page: 2759 ident: CR55 article-title: Ischemic preconditioning: neuronal survival in the face of caspase-3 activation publication-title: J. Neurosci. – volume: 32 start-page: 149 year: 2009 end-page: 184 ident: CR3 article-title: The glial nature of embryonic and adult neural stem cells publication-title: Annu. Rev. Neurosci. – volume: 376 start-page: 167 year: 1995 end-page: 170 ident: CR47 article-title: Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B publication-title: Nature – volume: 26 start-page: 2361 year: 2008 end-page: 2371 ident: CR20 article-title: Tumor necrosis factor-alpha modulates survival, proliferation, and neuronal differentiation in neonatal subventricular zone cell cultures publication-title: Stem Cells – volume: 135 start-page: 3298 year: 2012 end-page: 3310 ident: CR15 article-title: Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice publication-title: Brain – volume: 115 start-page: 61 year: 2003 end-page: 70 ident: CR44 article-title: A JNK-dependent pathway is required for TNFalpha-induced apoptosis publication-title: Cell – volume: 80 start-page: 789 year: 2005 end-page: 797 ident: CR35 article-title: Microglia-derived tumor necrosis factor-alpha exaggerates death of newborn hippocampal progenitor cells in vitro publication-title: J. Neurosci. Res. – volume: 2 start-page: 423 year: 1997 end-page: 441 ident: CR51 article-title: Life and death decisions: the role of the IAPs in modulating programmed cell death publication-title: Apoptosis – volume: 36 start-page: 742 year: 2002 end-page: 750 ident: CR56 article-title: Cytokine regulation of pro- and anti-apoptotic genes in rat hepatocytes: NF-kappaB-regulated inhibitor of apoptosis protein 2 (cIAP2) prevents apoptosis publication-title: J. Hepatol. – volume: 10 start-page: 205 year: 1998 end-page: 219 ident: CR40 article-title: Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development publication-title: Curr. Opin. Cell Biol. – volume: 290 start-page: G583 year: 2006 end-page: G589 ident: CR18 article-title: Mechanisms of liver injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways publication-title: Am. J. Physiol. Gastrointest. Liver Physiol. – volume: 274 start-page: 784 year: 1996 end-page: 787 ident: CR38 article-title: TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB publication-title: Science – volume: 414 start-page: 112 year: 2001 end-page: 117 ident: CR2 article-title: The development of neural stem cells publication-title: Nature – volume: 31 start-page: 235 year: 2011 end-page: 242 ident: CR7 article-title: Cell number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain publication-title: J. Cereb. Blood Flow. Metab. – volume: 97 start-page: 14720 year: 2000 end-page: 14725 ident: CR26 article-title: Direct isolation of human central nervous system stem cells publication-title: Proc. Natl Acad. Sci. USA – volume: 18 start-page: 6910 year: 1999 end-page: 6924 ident: CR46 article-title: Control of apoptosis by Rel/NF-kappaB transcription factors publication-title: Oncogene – volume: 85 start-page: 141 year: 1998 end-page: 152 ident: CR25 article-title: A new method for the rapid and long term growth of human neural precursor cells publication-title: J. Neurosci. Methods – volume: 7 start-page: 562 year: 2012 end-page: 578 ident: CR33 article-title: Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks publication-title: Nat. Protoc. – volume: 1802 start-page: 396 year: 2010 end-page: 405 ident: CR42 article-title: Pathological roles of MAPK signaling pathways in human diseases publication-title: Biochim. Biophys. Acta – volume: 7 start-page: e50783 year: 2012 ident: CR22 article-title: TNF-alpha affects human cortical neural progenitor cell differentiation through the autocrine secretion of leukemia inhibitory factor publication-title: PLoS ONE – volume: 26 start-page: 699 year: 2006 end-page: 708 ident: CR54 article-title: Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival publication-title: Mol. Cell. Biol. – volume: 165 start-page: 1743 year: 2000 end-page: 1754 ident: CR48 article-title: The NF-kappa B cascade is important in Bcl-xL expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4+lymphocytes publication-title: J. Immunol. – volume: 26 start-page: 143 year: 2006 end-page: 151 ident: CR19 article-title: Tumor necrosis factor alpha but not interleukin 1 beta mediates neuroprotection in response to acute nitric oxide excitotoxicity publication-title: J. Neurosci. – volume: 199 start-page: 222 year: 2006 end-page: 235 ident: CR28 article-title: Human neurospheres derived from the fetal central nervous system are regionally and temporally specified but are not committed publication-title: Exp. Neurol. – volume: 52 start-page: 855 year: 2010 end-page: 865 ident: CR4 article-title: Neural stem cells: properties and therapeutic potentials for hypoxic-ischemic brain injury in newborn infants publication-title: Pediatr. Int. – volume: 214 start-page: 584 year: 1994 end-page: 594 ident: CR37 article-title: Induction of endothelial cell apoptosis by TNF alpha: modulation by inhibitors of protein synthesis publication-title: Exp. Cell Res. – volume: 183 start-page: 121 year: 2017 end-page: 136.e19 ident: CR12 article-title: Neurogenin-2-transduced human neural progenitor cells attenuate neonatal hypoxic-ischemic brain injury publication-title: Transl. Res. – volume: 4 start-page: e5586 year: 2009 ident: CR11 article-title: Human neural stem cells genetically modified to overexpress Akt1 provide neuroprotection and functional improvement in mouse stroke m publication-title: PLoS ONE – volume: 13 start-page: 3510 year: 1993 end-page: 3524 ident: CR30 article-title: Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury publication-title: J. Neurosci. – volume: 64 start-page: 7183 year: 2004 end-page: 7190 ident: CR52 article-title: Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice publication-title: Cancer Res. – volume: 287 start-page: 2632 year: 2012 end-page: 2642 ident: CR49 article-title: p38alpha mediates cell survival in response to oxidative stress via induction of antioxidant genes: effect on the p70S6K pathway publication-title: J. Biol. Chem. – volume: 71 start-page: 92 year: 2011 end-page: 98 ident: CR14 article-title: GDNF-pretreatment enhances the survival of neural stem cells following transplantation in a rat model of Parkinson’s disease publication-title: Neurosci. Res. – volume: 25 start-page: 1105 year: 2009 end-page: 1111 ident: CR31 article-title: TopHat: discovering splice junctions with RNA-Seq publication-title: Bioinformatics – volume: 379 start-page: 349 year: 1996 end-page: 353 ident: CR50 article-title: Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes publication-title: Nature – volume: 43 start-page: 2423 year: 2012 end-page: 2429 ident: CR13 article-title: Neural stem cells genetically modified to overexpress cu/zn-superoxide dismutase enhance amelioration of ischemic stroke in mice publication-title: Stroke – volume: 25 start-page: 17 year: 2003 end-page: 24 ident: CR45 article-title: Activation of the JNK signaling pathway: breaking the brake on apoptosis publication-title: Bioessays – volume: 8 start-page: 1363 year: 2002 end-page: 1368 ident: CR17 article-title: The many faces of tumor necrosis factor in stroke publication-title: Nat. Med. – volume: 27 start-page: 2185 year: 2009 end-page: 2195 ident: CR9 article-title: Endothelial cells support survival, proliferation, and neuronal differentiation of transplanted adult ischemia-induced neural stem/progenitor cells after cerebral infarction publication-title: Stem Cells – volume: 129 start-page: 2734 year: 2006 end-page: 2745 ident: CR10 article-title: Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia publication-title: Brain – volume: 24 start-page: 2449 year: 2015 end-page: 2461 ident: CR16 article-title: BDNF pretreatment of human embryonic-derived neural stem cells improves cell survival and functional recovery after transplantation in hypoxic-ischemic stroke publication-title: Cell. Transplant. – volume: 37 start-page: 275 year: 2010 end-page: 283 ident: CR5 article-title: Optimizing the success of cell transplantation therapy for stroke publication-title: Neurobiol. Dis. – volume: 9 start-page: 357 year: 2012 end-page: 359 ident: CR32 article-title: Fast gapped-read alignment with Bowtie 2 publication-title: Nat. Methods – volume: 13 start-page: 239 year: 1999 end-page: 252 ident: CR53 article-title: IAP family proteins—suppressors of apoptosis publication-title: Genes Dev. – volume: 288 start-page: 870 year: 2000 end-page: 874 ident: CR41 article-title: Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway publication-title: Science – volume: 29 start-page: 562 year: 2009 end-page: 574 ident: CR8 article-title: Transplantation of human embryonic stem cell-derived neural precursor cells and enriched environment after cortical stroke in rats: cell survival and functional recovery publication-title: Eur. J. Neurosci. – volume: 210 start-page: 703 year: 2007 end-page: 710 ident: CR57 article-title: MAP kinase-dependent, NF-kappaB-independent regulation of inhibitor of apoptosis protein genes by TNF-alpha publication-title: J. Cell Physiol. – volume: 56 start-page: 903 year: 2008 end-page: 916 ident: CR21 article-title: HIV-1-infected and/or immune-activated macrophage-secreted TNF-alpha affects human fetal cortical neural progenitor cell proliferation and differentiation publication-title: Glia – volume: 66 start-page: 356 year: 2001 end-page: 368 ident: CR27 article-title: Identification and characterization of neuronal precursors and their progeny from human fetal tissue publication-title: J. Neurosci. Res. – volume: 1035 start-page: 290 year: 2004 end-page: 315 ident: CR34 article-title: New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists publication-title: Ann. N. Y. Acad. Sci. – volume: 134 start-page: 1777 year: 2011 end-page: 1789 ident: CR6 article-title: Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain publication-title: Brain – volume: 165 start-page: 1743 year: 2000 ident: 33_CR48 publication-title: J. Immunol. doi: 10.4049/jimmunol.165.4.1743 – volume: 4 start-page: e5586 year: 2009 ident: 33_CR11 publication-title: PLoS ONE doi: 10.1371/journal.pone.0005586 – volume: 7 start-page: e50783 year: 2012 ident: 33_CR22 publication-title: PLoS ONE doi: 10.1371/journal.pone.0050783 – volume: 376 start-page: 167 year: 1995 ident: 33_CR47 publication-title: Nature doi: 10.1038/376167a0 – volume: 37 start-page: 275 year: 2010 ident: 33_CR5 publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2009.10.003 – volume: 158 start-page: 265 year: 1999 ident: 33_CR29 publication-title: Exp. Neurol. doi: 10.1006/exnr.1999.7098 – volume: 414 start-page: 112 year: 2001 ident: 33_CR2 publication-title: Nature doi: 10.1038/35102174 – volume: 56 start-page: 903 year: 2008 ident: 33_CR21 publication-title: Glia doi: 10.1002/glia.20665 – volume: 214 start-page: 584 year: 1994 ident: 33_CR37 publication-title: Exp. Cell Res. doi: 10.1006/excr.1994.1296 – volume: 134 start-page: 1777 year: 2011 ident: 33_CR6 publication-title: Brain doi: 10.1093/brain/awr094 – volume: 1802 start-page: 396 year: 2010 ident: 33_CR42 publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbadis.2009.12.009 – volume: 26 start-page: 2361 year: 2008 ident: 33_CR20 publication-title: Stem Cells doi: 10.1634/stemcells.2007-0914 – volume: 27 start-page: 2185 year: 2009 ident: 33_CR9 publication-title: Stem Cells doi: 10.1002/stem.161 – volume: 135 start-page: 3298 year: 2012 ident: 33_CR15 publication-title: Brain doi: 10.1093/brain/aws259 – volume: 183 start-page: 121 year: 2017 ident: 33_CR12 publication-title: Transl. Res. doi: 10.1016/j.trsl.2016.12.010 – volume: 103 start-page: 239 year: 2000 ident: 33_CR39 publication-title: Cell doi: 10.1016/S0092-8674(00)00116-1 – volume: 70 start-page: 614 year: 2011 ident: 33_CR1 publication-title: Neuron doi: 10.1016/j.neuron.2011.05.005 – volume: 33 start-page: S417 year: 2005 ident: 33_CR24 publication-title: Crit. Care Med. doi: 10.1097/01.CCM.0000191714.39495.A6 – volume: 25 start-page: 17 year: 2003 ident: 33_CR45 publication-title: Bioessays doi: 10.1002/bies.10204 – volume: 36 start-page: 742 year: 2002 ident: 33_CR56 publication-title: J. Hepatol. doi: 10.1016/S0168-8278(02)00063-6 – volume: 8 start-page: 1363 year: 2002 ident: 33_CR17 publication-title: Nat. Med. doi: 10.1038/nm1202-1363 – volume: 10 start-page: 45 year: 2003 ident: 33_CR23 publication-title: Cell Death Differ. doi: 10.1038/sj.cdd.4401189 – volume: 85 start-page: 141 year: 1998 ident: 33_CR25 publication-title: J. Neurosci. Methods doi: 10.1016/S0165-0270(98)00126-5 – volume: 18 start-page: 6910 year: 1999 ident: 33_CR46 publication-title: Oncogene doi: 10.1038/sj.onc.1203238 – volume: 114 start-page: 181 year: 2003 ident: 33_CR36 publication-title: Cell doi: 10.1016/S0092-8674(03)00521-X – volume: 43 start-page: 2423 year: 2012 ident: 33_CR13 publication-title: Stroke doi: 10.1161/STROKEAHA.112.656900 – volume: 25 start-page: 1105 year: 2009 ident: 33_CR31 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp120 – volume: 10 start-page: 205 year: 1998 ident: 33_CR40 publication-title: Curr. Opin. Cell Biol. doi: 10.1016/S0955-0674(98)80143-9 – volume: 52 start-page: 855 year: 2010 ident: 33_CR4 publication-title: Pediatr. Int. doi: 10.1111/j.1442-200X.2010.03266.x – volume: 13 start-page: 239 year: 1999 ident: 33_CR53 publication-title: Genes Dev. doi: 10.1101/gad.13.3.239 – volume: 9 start-page: 357 year: 2012 ident: 33_CR32 publication-title: Nat. Methods doi: 10.1038/nmeth.1923 – volume: 199 start-page: 222 year: 2006 ident: 33_CR28 publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2006.03.015 – volume: 80 start-page: 789 year: 2005 ident: 33_CR35 publication-title: J. Neurosci. Res. doi: 10.1002/jnr.20531 – volume: 115 start-page: 61 year: 2003 ident: 33_CR44 publication-title: Cell doi: 10.1016/S0092-8674(03)00757-8 – volume: 287 start-page: 2632 year: 2012 ident: 33_CR49 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.323709 – volume: 288 start-page: 870 year: 2000 ident: 33_CR41 publication-title: Science doi: 10.1126/science.288.5467.870 – volume: 44 start-page: 164 year: 2003 ident: 33_CR43 publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.01-1201 – volume: 13 start-page: 3510 year: 1993 ident: 33_CR30 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.13-08-03510.1993 – volume: 32 start-page: 149 year: 2009 ident: 33_CR3 publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev.neuro.051508.135600 – volume: 379 start-page: 349 year: 1996 ident: 33_CR50 publication-title: Nature doi: 10.1038/379349a0 – volume: 7 start-page: 562 year: 2012 ident: 33_CR33 publication-title: Nat. Protoc. doi: 10.1038/nprot.2012.016 – volume: 66 start-page: 356 year: 2001 ident: 33_CR27 publication-title: J. Neurosci. Res. doi: 10.1002/jnr.1228 – volume: 129 start-page: 2734 year: 2006 ident: 33_CR10 publication-title: Brain doi: 10.1093/brain/awl207 – volume: 31 start-page: 235 year: 2011 ident: 33_CR7 publication-title: J. Cereb. Blood Flow. Metab. doi: 10.1038/jcbfm.2010.81 – volume: 29 start-page: 562 year: 2009 ident: 33_CR8 publication-title: Eur. J. Neurosci. doi: 10.1111/j.1460-9568.2008.06599.x – volume: 97 start-page: 14720 year: 2000 ident: 33_CR26 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.97.26.14720 – volume: 71 start-page: 92 year: 2011 ident: 33_CR14 publication-title: Neurosci. Res. doi: 10.1016/j.neures.2011.05.019 – volume: 1035 start-page: 290 year: 2004 ident: 33_CR34 publication-title: Ann. N. Y. Acad. Sci. doi: 10.1196/annals.1332.018 – volume: 26 start-page: 699 year: 2006 ident: 33_CR54 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.26.2.699-708.2006 – volume: 210 start-page: 703 year: 2007 ident: 33_CR57 publication-title: J. Cell Physiol. doi: 10.1002/jcp.20881 – volume: 24 start-page: 2449 year: 2015 ident: 33_CR16 publication-title: Cell. Transplant. doi: 10.3727/096368914X679354 – volume: 290 start-page: G583 year: 2006 ident: 33_CR18 publication-title: Am. J. Physiol. Gastrointest. Liver Physiol. doi: 10.1152/ajpgi.00422.2005 – volume: 24 start-page: 2750 year: 2004 ident: 33_CR55 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5475-03.2004 – volume: 26 start-page: 143 year: 2006 ident: 33_CR19 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.4032-05.2006 – volume: 274 start-page: 784 year: 1996 ident: 33_CR38 publication-title: Science doi: 10.1126/science.274.5288.784 – volume: 2 start-page: 423 year: 1997 ident: 33_CR51 publication-title: Apoptosis doi: 10.1023/A:1026465926478 – volume: 64 start-page: 7183 year: 2004 ident: 33_CR52 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-04-1918 |
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| Snippet | Neural progenitor cell (NPC) transplantation has been shown to be beneficial in the ischemic brain. However, the low survival rate of transplanted NPCs in an... Stroke: creating a safe haven for neurological repair A potent “survival signal” for brain stem cells could enable effective regenerative therapies for stroke... |
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| SubjectTerms | 13/1 13/100 13/2 14/63 38/39 42/89 45/44 631/378/87 631/532/2182 Apoptosis Baculoviral IAP Repeat-Containing 3 Protein - genetics Baculoviral IAP Repeat-Containing 3 Protein - metabolism Biomedical and Life Sciences Biomedicine Brain injury Cell survival Cell Survival - drug effects Cells, Cultured Cytotoxicity Fetuses Glucose - metabolism Humans Inflammation Intracellular signalling Ischemia Medical Biochemistry Molecular Medicine mRNA Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism NF-kappa B - metabolism NF-κB protein Oxygen Oxygen - metabolism p38 Mitogen-Activated Protein Kinases Progenitor cells Signal transduction Signal Transduction - drug effects Stem Cells Transplantation Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-TNF Tumor necrosis factor-α 생화학 |
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| Title | TNF-α induces human neural progenitor cell survival after oxygen–glucose deprivation by activating the NF-κB pathway |
| URI | https://link.springer.com/article/10.1038/s12276-018-0033-1 https://www.ncbi.nlm.nih.gov/pubmed/29622770 https://www.proquest.com/docview/2036806780 https://www.proquest.com/docview/2022994633 https://pubmed.ncbi.nlm.nih.gov/PMC5938012 https://doaj.org/article/b185d6e8def74fbf8a8603d23fb4d92a https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002342548 |
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| ispartofPNX | Experimental and Molecular Medicine, 2018, 50(0), , pp.1-14 |
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