Targeted delivery of black phosphorus nanosheets by ROS responsive complex hydrogel based on angiogenesis and antioxidant promotes myocardial infarction repair

• Published in: Journal of nanobiotechnology Vol. 22; no. 1; pp. 433 - 22
• Main Authors: Zhang, Jiahui, Sun, Di, Guo, Yishan, Tong, Junran, Liu, Qingyi, Gao, Ran, Wei, Yumiao, Guo, Xiaopeng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.07.2024; BioMed Central; BMC
• Subjects: Angiogenesis; Animals; Antioxidants - chemistry; Antioxidants - pharmacology; Biomaterials; Black phosphorus nanosheets; Care and treatment; Complications and side effects; Gels (Pharmacy); Health aspects; Heart attack; Hydrogel; Hydrogels - chemistry; Magnesium - chemistry; Magnesium - pharmacology; Male; Methods; Mice; Myocardial infarction; Myocardial Infarction - drug therapy; Nanomedicine; Nanostructures - chemistry; Neovascularization, Physiologic - drug effects; Oxidative Stress - drug effects; Patient outcomes; Phosphorus - chemistry; Phosphorus in the body; Reactive Oxygen Species - metabolism; ROS; Transluminal angioplasty; China; Myocardial infarction; Black phosphorus nanosheets; Hydrogel; ROS; Biomaterials

Myocardial infarction (MI) is one of the leading causes of death. This is attributed to the dramatic changes in the myocardial microenvironment post-MI. Therefore, effective intervention in the early stages of MI is significant for inhibiting its progression and improving cardiac function. Herein, a...