Ketamine decreases sensitivity of male rats to misleading negative feedback in a probabilistic reversal-learning task

• Published in: Psychopharmacology Vol. 234; no. 4; pp. 613 - 620
• Main Authors: Rychlik, Michal, Bollen, Eva, Rygula, Rafal
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2017; Springer; Springer Nature B.V
• Subjects: Analysis; Animals; Antidepressants; Antidepressive Agents - pharmacology; Attributional biases; Biomedical and Life Sciences; Biomedicine; Depression (Mood disorder); Dosage and administration; Dose-Response Relationship, Drug; Drug therapy; Feedback; Feedback (Communication); Ketamine; Ketamine - pharmacology; Male; Neurosciences; Original Investigation; Pharmacological research; Pharmacology/Toxicology; Physiological aspects; Psychiatry; Psychopharmacology; Rats; Rats, Sprague-Dawley; Reversal Learning - drug effects; Studies; Animal model; Feedback sensitivity; Probabilistic reversal learning; Ketamine; Rat

Rationale Depression is characterized by an excessive attribution of value to negative feedback. This imbalance in feedback sensitivity can be measured using the probabilistic reversal-learning (PRL) task. This task was initially designed for clinical research, but introduction of its rodent version...