Decreased gray matter volume in the left middle temporal gyrus as a candidate biomarker for schizophrenia: A study of drug naive, first-episode schizophrenia patients and unaffected siblings

• Published in: Schizophrenia research Vol. 159; no. 1; pp. 43 - 50
• Main Authors: Guo, Wenbin, Hu, Maorong, Fan, Xiaoduo, Liu, Feng, Wu, Renrong, Chen, Jindong, Guo, Xiaofeng, Xiao, Changqing, Quan, Meina, Chen, Huafu, Zhai, Jinguo, Zhao, Jingping
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.10.2014; Elsevier
• Subjects: Adult and adolescent clinical studies; Biological and medical sciences; Endophenotype; Endophenotypes; Female; First-episode schizophrenia; Gray matter; Gray Matter - pathology; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Medical sciences; Organ Size; Psychiatric Status Rating Scales; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; ROC Curve; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - pathology; Siblings; Temporal Lobe - pathology; Unaffected siblings; Voxel-based morphometry; Young Adult; First-episode schizophrenia; Unaffected siblings; Gray matter; Voxel-based morphometry; Endophenotype; Human; Temporal lobe; Grey matter; Central nervous system; Biological marker; Schizophrenia; Sibling; Encephalon; Psychosis; First episode; Morphometry

Studies have shown that patients with schizophrenia and their siblings share decreased gray matter (GM) volumes in certain brain regions, which may represent candidate endophenotypes of schizophrenia. However, the specificity and utility of these possible endophenotypes in relation to schizophrenia...