Genome-wide association study identifies new susceptibility loci for cutaneous lupus erythematosus

• Published in: Experimental dermatology Vol. 24; no. 7; pp. 510 - 515
• Main Authors: Kunz, Manfred, König, Inke R., Schillert, Arne, Kruppa, Jochen, Ziegler, Andreas, Grallert, Harald, Müller-Nurasyid, Martina, Lieb, Wolfgang, Franke, Andre, Ranki, Annamari, Panelius, Jaana, Koskenmies, Sari, Hasan, Taina, Kere, Juha, Rönn, Ann-Charlotte, Simon, Jan C., Schmidt, Enno, Wenzel, Joerg, Tüting, Thomas, Landsberg, Jennifer, Zeller, Tanja, Blankenberg, Stefan, Gläser, Regine, Patsinakidis, Nikolaos, Kuhn, Annegret, Ibrahim, Saleh M.
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.07.2015
• Subjects: autoimmune diseases; Carrier Proteins - genetics; Case-Control Studies; Cell Cycle Proteins - genetics; Chromosomes, Human, Pair 6 - genetics; Finland; Genetic Predisposition to Disease; genetics; Genome-Wide Association Study; Germany; Histocompatibility Antigens Class I - genetics; HLA-DQ alpha-Chains - genetics; Humans; lupus; Lupus Erythematosus, Cutaneous - genetics; Lupus Erythematosus, Cutaneous - immunology; Major Histocompatibility Complex; Polymorphism, Single Nucleotide; Ribonuclease P - genetics; single nucleotide polymorphisms; Germany; Finland; autoimmune diseases; genetics; single nucleotide polymorphisms; lupus

Cutaneous lupus erythematosus (CLE) is a chronic autoimmune disease of the skin with typical clinical manifestations. Here, we genotyped 906 600 single nucleotide polymorphisms (SNPs) in 183 CLE cases and 1288 controls of Central European ancestry. Replication was performed for 13 SNPs in 219 case s...