Acoustic enhancement of sleep slow oscillations in mild cognitive impairment

Objective Slow‐wave activity (SWA) during sleep is reduced in people with amnestic mild cognitive impairment (aMCI) and is related to sleep‐dependent memory consolidation. Acoustic stimulation of slow oscillations has proven effective in enhancing SWA and memory in younger and older adults. In this...

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Published inAnnals of clinical and translational neurology Vol. 6; no. 7; pp. 1191 - 1201
Main Authors Papalambros, Nelly A., Weintraub, Sandra, Chen, Tammy, Grimaldi, Daniela, Santostasi, Giovanni, Paller, Ken A., Zee, Phyllis C., Malkani, Roneil G.
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.07.2019
John Wiley and Sons Inc
Wiley
Subjects
Acoustic Stimulation
Acoustics
Age
Aged
Aged, 80 and over
Aging
Alzheimer's disease
Atrophy
Cognitive ability
Cognitive Dysfunction - physiopathology
Cross-Over Studies
Dementia
Electroencephalography
Health care
Humans
Hypotheses
Memory
Memory Consolidation
Mental Recall - physiology
Middle Aged
Scholarships & fellowships
Sleep apnea
Sleep, Slow-Wave - physiology
United States > US
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Abstract Objective Slow‐wave activity (SWA) during sleep is reduced in people with amnestic mild cognitive impairment (aMCI) and is related to sleep‐dependent memory consolidation. Acoustic stimulation of slow oscillations has proven effective in enhancing SWA and memory in younger and older adults. In this study we aimed to determine whether acoustic stimulation during sleep boosts SWA and improves memory performance in people with aMCI. Methods Nine adults with aMCI (72 ± 8.7 years) completed one night of acoustic stimulation (stim) and one night of sham stimulation (sham) in a blinded, randomized crossover study. Acoustic stimuli were delivered phase‐locked to the upstate of the endogenous sleep slow‐waves. Participants completed a declarative recall task with 44 word‐pairs before and after sleep. Results During intervals of acoustic stimulation, SWA increased by >10% over sham intervals (P < 0.01), but memory recall increased in only five of the nine patients. The increase in SWA with stimulation was associated with improved morning word recall (r = 0.78, P = 0.012). Interpretation Acoustic stimulation delivered during slow‐wave sleep over one night was effective for enhancing SWA in individuals with aMCI. Given established relationships between SWA and memory, a larger or more prolonged enhancement may be needed to consistently improve memory in aMCI.
AbstractList Slow-wave activity (SWA) during sleep is reduced in people with amnestic mild cognitive impairment (aMCI) and is related to sleep-dependent memory consolidation. Acoustic stimulation of slow oscillations has proven effective in enhancing SWA and memory in younger and older adults. In this study we aimed to determine whether acoustic stimulation during sleep boosts SWA and improves memory performance in people with aMCI. Nine adults with aMCI (72 ± 8.7 years) completed one night of acoustic stimulation (stim) and one night of sham stimulation (sham) in a blinded, randomized crossover study. Acoustic stimuli were delivered phase-locked to the upstate of the endogenous sleep slow-waves. Participants completed a declarative recall task with 44 word-pairs before and after sleep. During intervals of acoustic stimulation, SWA increased by >10% over sham intervals (P < 0.01), but memory recall increased in only five of the nine patients. The increase in SWA with stimulation was associated with improved morning word recall (r = 0.78, P = 0.012). Acoustic stimulation delivered during slow-wave sleep over one night was effective for enhancing SWA in individuals with aMCI. Given established relationships between SWA and memory, a larger or more prolonged enhancement may be needed to consistently improve memory in aMCI.
Objective Slow‐wave activity (SWA) during sleep is reduced in people with amnestic mild cognitive impairment (aMCI) and is related to sleep‐dependent memory consolidation. Acoustic stimulation of slow oscillations has proven effective in enhancing SWA and memory in younger and older adults. In this study we aimed to determine whether acoustic stimulation during sleep boosts SWA and improves memory performance in people with aMCI. Methods Nine adults with aMCI (72 ± 8.7 years) completed one night of acoustic stimulation (stim) and one night of sham stimulation (sham) in a blinded, randomized crossover study. Acoustic stimuli were delivered phase‐locked to the upstate of the endogenous sleep slow‐waves. Participants completed a declarative recall task with 44 word‐pairs before and after sleep. Results During intervals of acoustic stimulation, SWA increased by >10% over sham intervals (P < 0.01), but memory recall increased in only five of the nine patients. The increase in SWA with stimulation was associated with improved morning word recall (r = 0.78, P = 0.012). Interpretation Acoustic stimulation delivered during slow‐wave sleep over one night was effective for enhancing SWA in individuals with aMCI. Given established relationships between SWA and memory, a larger or more prolonged enhancement may be needed to consistently improve memory in aMCI.
Abstract Objective Slow‐wave activity (SWA) during sleep is reduced in people with amnestic mild cognitive impairment (aMCI) and is related to sleep‐dependent memory consolidation. Acoustic stimulation of slow oscillations has proven effective in enhancing SWA and memory in younger and older adults. In this study we aimed to determine whether acoustic stimulation during sleep boosts SWA and improves memory performance in people with aMCI. Methods Nine adults with aMCI (72 ± 8.7 years) completed one night of acoustic stimulation (stim) and one night of sham stimulation (sham) in a blinded, randomized crossover study. Acoustic stimuli were delivered phase‐locked to the upstate of the endogenous sleep slow‐waves. Participants completed a declarative recall task with 44 word‐pairs before and after sleep. Results During intervals of acoustic stimulation, SWA increased by >10% over sham intervals (P < 0.01), but memory recall increased in only five of the nine patients. The increase in SWA with stimulation was associated with improved morning word recall (r = 0.78, P = 0.012). Interpretation Acoustic stimulation delivered during slow‐wave sleep over one night was effective for enhancing SWA in individuals with aMCI. Given established relationships between SWA and memory, a larger or more prolonged enhancement may be needed to consistently improve memory in aMCI.
ObjectiveSlow‐wave activity (SWA) during sleep is reduced in people with amnestic mild cognitive impairment (aMCI) and is related to sleep‐dependent memory consolidation. Acoustic stimulation of slow oscillations has proven effective in enhancing SWA and memory in younger and older adults. In this study we aimed to determine whether acoustic stimulation during sleep boosts SWA and improves memory performance in people with aMCI.MethodsNine adults with aMCI (72 ± 8.7 years) completed one night of acoustic stimulation (stim) and one night of sham stimulation (sham) in a blinded, randomized crossover study. Acoustic stimuli were delivered phase‐locked to the upstate of the endogenous sleep slow‐waves. Participants completed a declarative recall task with 44 word‐pairs before and after sleep.ResultsDuring intervals of acoustic stimulation, SWA increased by >10% over sham intervals (P < 0.01), but memory recall increased in only five of the nine patients. The increase in SWA with stimulation was associated with improved morning word recall (r = 0.78, P = 0.012).InterpretationAcoustic stimulation delivered during slow‐wave sleep over one night was effective for enhancing SWA in individuals with aMCI. Given established relationships between SWA and memory, a larger or more prolonged enhancement may be needed to consistently improve memory in aMCI.
Slow-wave activity (SWA) during sleep is reduced in people with amnestic mild cognitive impairment (aMCI) and is related to sleep-dependent memory consolidation. Acoustic stimulation of slow oscillations has proven effective in enhancing SWA and memory in younger and older adults. In this study we aimed to determine whether acoustic stimulation during sleep boosts SWA and improves memory performance in people with aMCI.OBJECTIVESlow-wave activity (SWA) during sleep is reduced in people with amnestic mild cognitive impairment (aMCI) and is related to sleep-dependent memory consolidation. Acoustic stimulation of slow oscillations has proven effective in enhancing SWA and memory in younger and older adults. In this study we aimed to determine whether acoustic stimulation during sleep boosts SWA and improves memory performance in people with aMCI.Nine adults with aMCI (72 ± 8.7 years) completed one night of acoustic stimulation (stim) and one night of sham stimulation (sham) in a blinded, randomized crossover study. Acoustic stimuli were delivered phase-locked to the upstate of the endogenous sleep slow-waves. Participants completed a declarative recall task with 44 word-pairs before and after sleep.METHODSNine adults with aMCI (72 ± 8.7 years) completed one night of acoustic stimulation (stim) and one night of sham stimulation (sham) in a blinded, randomized crossover study. Acoustic stimuli were delivered phase-locked to the upstate of the endogenous sleep slow-waves. Participants completed a declarative recall task with 44 word-pairs before and after sleep.During intervals of acoustic stimulation, SWA increased by >10% over sham intervals (P < 0.01), but memory recall increased in only five of the nine patients. The increase in SWA with stimulation was associated with improved morning word recall (r = 0.78, P = 0.012).RESULTSDuring intervals of acoustic stimulation, SWA increased by >10% over sham intervals (P < 0.01), but memory recall increased in only five of the nine patients. The increase in SWA with stimulation was associated with improved morning word recall (r = 0.78, P = 0.012).Acoustic stimulation delivered during slow-wave sleep over one night was effective for enhancing SWA in individuals with aMCI. Given established relationships between SWA and memory, a larger or more prolonged enhancement may be needed to consistently improve memory in aMCI.INTERPRETATIONAcoustic stimulation delivered during slow-wave sleep over one night was effective for enhancing SWA in individuals with aMCI. Given established relationships between SWA and memory, a larger or more prolonged enhancement may be needed to consistently improve memory in aMCI.
Author Santostasi, Giovanni
Zee, Phyllis C.
Chen, Tammy
Paller, Ken A.
Papalambros, Nelly A.
Malkani, Roneil G.
Weintraub, Sandra
Grimaldi, Daniela
AuthorAffiliation 2 Center for Circadian and Sleep Medicine Northwestern University Feinberg School of Medicine Chicago Illinois
1 Department of Neurology Northwestern University Feinberg School of Medicine Chicago Illinois
3 Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine Chicago Illinois
4 Department of Psychiatry and Behavioral Sciences Northwestern University Feinberg School of Medicine Chicago Illinois
5 DeepWave Technologies Encinitas California
6 Department of Psychology Northwestern University Evanston Illinois
AuthorAffiliation_xml – name: 1 Department of Neurology Northwestern University Feinberg School of Medicine Chicago Illinois
– name: 5 DeepWave Technologies Encinitas California
– name: 6 Department of Psychology Northwestern University Evanston Illinois
– name: 3 Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine Chicago Illinois
– name: 4 Department of Psychiatry and Behavioral Sciences Northwestern University Feinberg School of Medicine Chicago Illinois
– name: 2 Center for Circadian and Sleep Medicine Northwestern University Feinberg School of Medicine Chicago Illinois
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  surname: Papalambros
  fullname: Papalambros, Nelly A.
  organization: Northwestern University Feinberg School of Medicine
– sequence: 2
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  surname: Weintraub
  fullname: Weintraub, Sandra
  organization: Northwestern University Feinberg School of Medicine
– sequence: 3
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  surname: Chen
  fullname: Chen, Tammy
  organization: Northwestern University Feinberg School of Medicine
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  surname: Grimaldi
  fullname: Grimaldi, Daniela
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  surname: Paller
  fullname: Paller, Ken A.
  organization: Northwestern University
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  surname: Zee
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  givenname: Roneil G.
  surname: Malkani
  fullname: Malkani, Roneil G.
  email: r-malkani@northwestern.edu
  organization: Northwestern University Feinberg School of Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31353857$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright 2019 The Authors. published by Wiley Periodicals, Inc on behalf of American Neurological Association.
2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
Copyright John Wiley & Sons, Inc. Jul 2019
Copyright_xml – notice: 2019 The Authors. published by Wiley Periodicals, Inc on behalf of American Neurological Association.
– notice: 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
– notice: Copyright John Wiley & Sons, Inc. Jul 2019
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2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
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Notes This work was funded by Alzheimer's Association (NIRG 15‐364483), Illinois Department of Public Health (63282002D), National Institute on Aging (P01AG11412 (PI: Zee) and P30AG013854 (PI: Mesulam)), National Institutes of Health (T32NS047987), National Science Foundation Graduate Research Fellowship Program (DGE‐1324585) and Northwestern University Center for Circadian and Sleep Medicine.
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Funding information
ORCID 0000-0002-6183-7635
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Snippet Objective Slow‐wave activity (SWA) during sleep is reduced in people with amnestic mild cognitive impairment (aMCI) and is related to sleep‐dependent memory...
Slow-wave activity (SWA) during sleep is reduced in people with amnestic mild cognitive impairment (aMCI) and is related to sleep-dependent memory...
ObjectiveSlow‐wave activity (SWA) during sleep is reduced in people with amnestic mild cognitive impairment (aMCI) and is related to sleep‐dependent memory...
Abstract Objective Slow‐wave activity (SWA) during sleep is reduced in people with amnestic mild cognitive impairment (aMCI) and is related to sleep‐dependent...
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StartPage 1191
SubjectTerms Acoustic Stimulation
Acoustics
Age
Aged
Aged, 80 and over
Aging
Alzheimer's disease
Atrophy
Cognitive ability
Cognitive Dysfunction - physiopathology
Cross-Over Studies
Dementia
Electroencephalography
Health care
Humans
Hypotheses
Memory
Memory Consolidation
Mental Recall - physiology
Middle Aged
Scholarships & fellowships
Sleep apnea
Sleep, Slow-Wave - physiology
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Title Acoustic enhancement of sleep slow oscillations in mild cognitive impairment
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Facn3.796
https://www.ncbi.nlm.nih.gov/pubmed/31353857
https://www.proquest.com/docview/2262102044
https://www.proquest.com/docview/2266333935
https://pubmed.ncbi.nlm.nih.gov/PMC6649400
https://doaj.org/article/dfafbae3ada34b63a7ae805f3f0520c8
Volume 6
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