Occupational exposure to phenoxy herbicides and chlorophenols and cancer mortality in The Netherlands
As part of the "IARC International Register of Persons Exposed to Phenoxy Herbicides and Contaminants," a cohort of workers who manufacture and prepare chlorophenoxy herbicides was recruited in The Netherlands. The cohort comprised 2,310 workers from two plants, operated by different compa...
Saved in:
Published in | American journal of industrial medicine Vol. 23; no. 2; p. 289 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.02.1993
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | As part of the "IARC International Register of Persons Exposed to Phenoxy Herbicides and Contaminants," a cohort of workers who manufacture and prepare chlorophenoxy herbicides was recruited in The Netherlands. The cohort comprised 2,310 workers from two plants, operated by different companies, who were followed during the periods 1955-1985 and 1965-1986, respectively. In 1963, there had been an industrial accident in one factory with concomitant release of dioxin into the environment. Loss to follow-up was 3%. Mortality data on 963 exposed and 1,111 nonexposed men were evaluated by external and internal comparison. Compared with national rates, total mortality (94 deaths, standardized mortality ratio [SMR] = 101; 95% confidence interval [CI], 82-124) and cancer mortality (31 deaths, SMR = 107; 95% CI, 73-152) for exposed workers were not significantly increased. A statistically insignificant increase was observed for non-Hodgkin's lymphoma (2 deaths, SMR = 299; 95% CI, 36-1,078). No cases of soft-tissue sarcoma were encountered. There was no increase in either total mortality (25 deaths, SMR = 111; 95% CI, 72-163) or cancer mortality (10 deaths, SMR = 137; 95% CI, 66-252) among the 139 workers probably exposed to dioxins during the 2,4,5-trichlorophenol production accident or the subsequent clean-up operations. Compared with nonexposed workers, exposed workers did not exhibit a higher total mortality (rate ratio [RR] = 1.28; 95% CI, 0.89-1.82). Mortality due to all cancers (RR = 1.7; 95% CI, 0.9-3.4) and respiratory cancer (RR = 1.7; 95% CI, 0.5-6.3) was insignificantly elevated. These findings suggest that the increases in cancer mortality among workers exposed to phenoxy herbicides and chlorophenols may be attributable to chance. Lack of power prevented evaluation with respect to specific cancers. |
---|---|
AbstractList | As part of the "IARC International Register of Persons Exposed to Phenoxy Herbicides and Contaminants," a cohort of workers who manufacture and prepare chlorophenoxy herbicides was recruited in The Netherlands. The cohort comprised 2,310 workers from two plants, operated by different companies, who were followed during the periods 1955-1985 and 1965-1986, respectively. In 1963, there had been an industrial accident in one factory with concomitant release of dioxin into the environment. Loss to follow-up was 3%. Mortality data on 963 exposed and 1,111 nonexposed men were evaluated by external and internal comparison. Compared with national rates, total mortality (94 deaths, standardized mortality ratio [SMR] = 101; 95% confidence interval [CI], 82-124) and cancer mortality (31 deaths, SMR = 107; 95% CI, 73-152) for exposed workers were not significantly increased. A statistically insignificant increase was observed for non-Hodgkin's lymphoma (2 deaths, SMR = 299; 95% CI, 36-1,078). No cases of soft-tissue sarcoma were encountered. There was no increase in either total mortality (25 deaths, SMR = 111; 95% CI, 72-163) or cancer mortality (10 deaths, SMR = 137; 95% CI, 66-252) among the 139 workers probably exposed to dioxins during the 2,4,5-trichlorophenol production accident or the subsequent clean-up operations. Compared with nonexposed workers, exposed workers did not exhibit a higher total mortality (rate ratio [RR] = 1.28; 95% CI, 0.89-1.82). Mortality due to all cancers (RR = 1.7; 95% CI, 0.9-3.4) and respiratory cancer (RR = 1.7; 95% CI, 0.5-6.3) was insignificantly elevated. These findings suggest that the increases in cancer mortality among workers exposed to phenoxy herbicides and chlorophenols may be attributable to chance. Lack of power prevented evaluation with respect to specific cancers. |
Author | Winkelmann, R Van der Kuip, D A Kogevinas, M Bueno de Mesquita, H B Doornbos, G |
Author_xml | – sequence: 1 givenname: H B surname: Bueno de Mesquita fullname: Bueno de Mesquita, H B organization: Department of Epidemiology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands – sequence: 2 givenname: G surname: Doornbos fullname: Doornbos, G – sequence: 3 givenname: D A surname: Van der Kuip fullname: Van der Kuip, D A – sequence: 4 givenname: M surname: Kogevinas fullname: Kogevinas, M – sequence: 5 givenname: R surname: Winkelmann fullname: Winkelmann, R |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8427257$$D View this record in MEDLINE/PubMed |
BookMark | eNotj81qwzAQhHVISZO0554KegGnkizJ8rGE_kFoLuk5SPIKK9iSkW2I376mNXvYZXZm4NuiVYgBEHqiZE8JYS_66ts9L-YzJ4zIFdoQVtAsF0reo23fXwmhlEu-RmvFWcFEsUFwsnbs9OBj0A2GWxf7MQEeIu5qCPE24RqS8dZX0GMdKmzrJqb492wWRQcLCbcxDbrxw4R9wOca8DcMc7aZLf0DunO66eFx2Tv08_52Pnxmx9PH1-H1mFlREJmV0nFu51GCGae1cTMGECNKV0DulOG6koS62S1FyRWzogIqiVTGWGFztkPP_73daFqoLl3yrU7TZcFlv4PuWak |
CitedBy_id | crossref_primary_10_1080_026520300283379 crossref_primary_10_1093_bmb_ldv008 crossref_primary_10_1002_em_21802 crossref_primary_10_1007_s10552_005_0443_y crossref_primary_10_1136_oem_2004_018622 crossref_primary_10_1136_oem_2010_058016 crossref_primary_10_1002__SICI_1097_0045_19981001_37_2_98__AID_PROS6_3_0_CO_2_H crossref_primary_10_1155_2013_371610 crossref_primary_10_1016_j_envres_2007_09_002 crossref_primary_10_1007_s10552_007_0122_2 crossref_primary_10_1016_j_ecoenv_2024_116345 crossref_primary_10_1007_s10654_014_9931_2 crossref_primary_10_1080_026520300283388 crossref_primary_10_1097_01_jom_0000111603_84316_0f crossref_primary_10_1136_oem_2010_060426 crossref_primary_10_3109_10408449609048302 crossref_primary_10_1093_aje_kwp153 crossref_primary_10_1016_j_watres_2013_11_043 crossref_primary_10_1097_CEJ_0b013e3280145b4c crossref_primary_10_1016_j_tox_2016_10_007 crossref_primary_10_1093_aje_kwn295 crossref_primary_10_1038_srep38012 crossref_primary_10_1111_j_1600_0463_2001_tb05771_x crossref_primary_10_2105_AJPH_87_1_71 crossref_primary_10_1016_j_ecoenv_2021_112327 crossref_primary_10_1158_1055_9965_EPI_13_0651 crossref_primary_10_1021_acs_est_3c07588 crossref_primary_10_20964_2022_05_26 crossref_primary_10_1016_S0045_6535_98_00239_2 crossref_primary_10_1016_j_toxlet_2012_02_007 crossref_primary_10_1038_sj_jea_7500208 crossref_primary_10_1093_annonc_11_suppl_1_S75 crossref_primary_10_1136_oem_2008_044222 crossref_primary_10_1136_oemed_2023_109167 crossref_primary_10_1016_j_abb_2015_10_007 |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1002/ajim.4700230206 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Medicine |
ExternalDocumentID | 8427257 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GeographicLocations | Netherlands |
GeographicLocations_xml | – name: Netherlands |
GroupedDBID | --- .3N .GA .GJ .Y3 05W 0R~ 10A 1L6 1OB 1OC 1ZS 23M 31~ 33P 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5VS 66C 6P2 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABEFU ABEML ABIJN ABJNI ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACGOF ACMXC ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFNX AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CGR CS3 CUY CVF D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DUUFO EBS ECM EIF EJD EMOBN F00 F01 F04 F3I F5P FEDTE FUBAC G-S G.N GNP GODZA H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IX1 J0M JPC KBYEO KD1 KQQ L7B LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M67 MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NNB NPM O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K RIWAO RJQFR ROL RWI RX1 RYL SAMSI SUPJJ TEORI UB1 V2E W8V W99 WBKPD WHWMO WIB WIH WIJ WIK WJL WOHZO WQJ WRC WUP WVDHM WWH WXI WXSBR XG1 XV2 ZGI ZXP ZZTAW ~02 ~IA ~WT |
ID | FETCH-LOGICAL-c5706-96f44c4c4852bfaabf206e0b59f7e3f8b4ad601fc57659482c5de16068bbc5c32 |
ISSN | 0271-3586 |
IngestDate | Sat Sep 28 08:33:57 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 2 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c5706-96f44c4c4852bfaabf206e0b59f7e3f8b4ad601fc57659482c5de16068bbc5c32 |
PMID | 8427257 |
ParticipantIDs | pubmed_primary_8427257 |
PublicationCentury | 1900 |
PublicationDate | February 1993 |
PublicationDateYYYYMMDD | 1993-02-01 |
PublicationDate_xml | – month: 02 year: 1993 text: February 1993 |
PublicationDecade | 1990 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | American journal of industrial medicine |
PublicationTitleAlternate | Am J Ind Med |
PublicationYear | 1993 |
SSID | ssj0011464 |
Score | 1.6365402 |
Snippet | As part of the "IARC International Register of Persons Exposed to Phenoxy Herbicides and Contaminants," a cohort of workers who manufacture and prepare... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 289 |
SubjectTerms | Adult Chemical Industry Chlorophenols - adverse effects Cohort Studies Herbicides - adverse effects Humans Male Middle Aged Neoplasms - chemically induced Neoplasms - mortality Netherlands - epidemiology Occupational Diseases - chemically induced Occupational Diseases - mortality Occupational Exposure - adverse effects Retrospective Studies |
Title | Occupational exposure to phenoxy herbicides and chlorophenols and cancer mortality in The Netherlands |
URI | https://www.ncbi.nlm.nih.gov/pubmed/8427257 |
Volume | 23 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLa6IdBeJm4TMEB-4K3KSB07cR7RBqqYuqdN2ttkOzYE0biUVtr2U_i1HF9yaQcIUKWosqu0yff15Bz7nO8g9CZTlaBlahJRpDShmZwkApiUFIyBdyS45r7ZxOwsn17Qj5fscjT6MchaWq_kkbr9ZV3J_6AKY4Crq5L9B2S7k8IAvAd84QgIw_GvMN6QCNbXC-uW-5w36RK37PUNuIFLWau60kGJWX2G6Nz6ya9xxIG-HM-9E-4c8rrxSRhbdcCdTm27v7MhONE1_7izUb-GbxpXYDn092_rOjiq077R84m1y0batm27aVt_jZ3Axem69r3zTvrl1lP7CZ7jTahBm_ULFiE9sEv-CHaNFJMkY1EBOxrhUHQcyUaGFjV0GLpj6YNyrPhSz49o4SMp4qULVgPcF3MPPKekIEEG-4-TW8LbcWYH7RTc2c4ztw4U96fg-eKFydpLaUWjUvJ26yftofvxRFuBi3dgzh-i_Rh54HeBRo_QSDeP0YNZhOwJ0kM24ZZNeGVxZBPu2YSBGHiDTWHEswl3bMJ1g4FNeMCmp-jiw_vz42kSm3AkihVpnpS5oVTBizMijRDSwEXpVLLSFDozXFJRQVBv4NO5k_4hilV6AmExl1IxlZEDtNvYRj9DuNKlNs6_zXhOU8VKInkG4W2mJsKkQj1HB-EGXS2C0spVvHMvfjdxiPZ6hr1E9wz8sfUr8BJX8rUH7CdhU2nn |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Occupational+exposure+to+phenoxy+herbicides+and+chlorophenols+and+cancer+mortality+in+The+Netherlands&rft.jtitle=American+journal+of+industrial+medicine&rft.au=Bueno+de+Mesquita%2C+H+B&rft.au=Doornbos%2C+G&rft.au=Van+der+Kuip%2C+D+A&rft.au=Kogevinas%2C+M&rft.date=1993-02-01&rft.issn=0271-3586&rft.volume=23&rft.issue=2&rft.spage=289&rft_id=info:doi/10.1002%2Fajim.4700230206&rft_id=info%3Apmid%2F8427257&rft_id=info%3Apmid%2F8427257&rft.externalDocID=8427257 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0271-3586&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0271-3586&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0271-3586&client=summon |