MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis

• Published in: The EMBO journal Vol. 31; no. 2; pp. 481 - 493
• Main Authors: Hosono, Yasuyuki, Yamaguchi, Tomoya, Mizutani, Eri, Yanagisawa, Kiyoshi, Arima, Chinatsu, Tomida, Shuta, Shimada, Yukako, Hiraoka, Michiyo, Kato, Seiichi, Yokoi, Kohei, Suzuki, Motoshi, Takahashi, Takashi
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 18.01.2012; Nature Publishing Group UK; Blackwell Publishing Ltd; Nature Publishing Group
• Subjects: actomyosin; Actomyosin - metabolism; Adenocarcinoma - pathology; Animals; Cell adhesion & migration; Cell Line; Cell Line, Tumor; Cell Movement - physiology; Cell Shape; Cellular biology; CpG Islands - genetics; Cytoskeletal Proteins - physiology; Cytoskeleton; Deoxyribonucleic acid; DNA; DNA Methylation; DNA-Binding Proteins - antagonists & inhibitors; DNA-Binding Proteins - physiology; Dogs; EMBO05; Gene Expression Regulation, Neoplastic; Humans; Kidney; Lung cancer; Lung Neoplasms - pathology; Metastasis; Myosin Light Chains - metabolism; Neoplasm Invasiveness; Neoplasm Metastasis - physiopathology; Phosphorylation; Promoter Regions, Genetic - genetics; Protein Processing, Post-Translational; rho-Associated Kinases - antagonists & inhibitors; rho-Associated Kinases - physiology; ROCK1; Transcription Factors; Transcriptional Activation; lung cancer; ROCK1; cytoskeleton; actomyosin

Cell migration driven by actomyosin filament assembly is a critical step in tumour invasion and metastasis. Herein, we report identification of myosin binding protein H ( MYBPH ) as a transcriptional target of TTF‐1 (also known as NKX2‐1 and TITF1 ), a master regulator of lung development that also...