Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity

• Published in: Inflammatory bowel diseases Vol. 16; no. 9; pp. 1557 - 1566
• Main Authors: Hong, Shih-Kuang S., Chaturvedi, Rupesh, Piazuelo, Blanca M., Coburn, Lori A., Williams, Christopher S., Delgado, Alberto G., Casero, Robert A., Schwartz, David A., Wilson, Keith T.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford University Press 01.09.2010; Wiley Subscription Services, Inc., A Wiley Company
• Subjects: Adult; Aged; Biopsy; Carcinogenesis; Case-Control Studies; Colitis, Ulcerative - diagnosis; Colitis, Ulcerative - enzymology; Colitis, Ulcerative - genetics; Colon; Colon - enzymology; Colon - pathology; Colonoscopy; Colorectal cancer; disease activity index; Endoscopy; Enzymes; Female; Gene expression; Homeostasis; Humans; Hydrogen peroxide; Immune response; Immunohistochemistry; Inflammation - diagnosis; Inflammation - enzymology; Inflammation - genetics; Inflammatory bowel disease; Inflammatory bowel diseases; Injuries; Intestine; Male; Metabolism; Middle Aged; Oxidative stress; Oxidoreductases Acting on CH-NH Group Donors - metabolism; Polyamine Oxidase; Polyamines; Polymerase chain reaction; Prognosis; Prospective Studies; Spermidine; Spermine; spermine oxidase; Ulcerative colitis; Up-Regulation; Wound healing; Young Adult; ulcerative colitis; immunohistochemistry; polyamines; gene expression; disease activity index; spermine oxidase

Polyamines are important in cell growth and wound repair, but have also been implicated in inflammation-induced carcinogenesis. Polyamine metabolism includes back-conversion of spermine to spermidine by the enzyme spermine oxidase (SMO), which produces hydrogen peroxide that causes oxidative stress....