Osteomalacia: The Missing Link in the Pathogenesis of Bisphosphonate‐Related Osteonecrosis of the Jaws?

• Published in: The oncologist (Dayton, Ohio) Vol. 17; no. 8; pp. 1114 - 1119
• Main Authors: Bedogni, Alberto, Saia, Giorgia, Bettini, Giordana, Tronchet, Anita, Totola, Andrea, Bedogni, Giorgio, Tregnago, Paolo, Valenti, Maria Teresa, Bertoldo, Francesco, Ferronato, Giuseppe, Nocini, Pier Francesco, Blandamura, Stella, Dalle Carbonare, Luca
• Format: Journal Article
• Language: English
• Published: Durham, NC, USA AlphaMed Press 01.08.2012
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Bisphosphonate; Bisphosphonate-Associated Osteonecrosis of the Jaw - complications; Bisphosphonate-Associated Osteonecrosis of the Jaw - pathology; Bone Density Conservation Agents - therapeutic use; Bone Density Conservation Agents - toxicity; Calcification, Physiologic - drug effects; Diphosphonates - therapeutic use; Diphosphonates - toxicity; Female; Humans; Jaw; Male; Middle Aged; Osteomalacia; Osteomalacia - chemically induced; Osteomalacia - complications; Osteomalacia - pathology; Osteonecrosis; Risk factor; Risk Factors; Symptom Management and Supportive Care

Background. Bisphosphonate‐related osteonecrosis of the jaw (BRONJ) is a well‐documented adverse event from treatment with nitrogen‐containing bisphosphonates (NBPs). During a preliminary histomorphometric study aimed at assessing the rate of bone remodeling in the jaws of patients with surgically r...