单源双能量CT平扫对肾上腺乏脂性腺瘤与转移瘤的鉴别价值

目的探讨单源双能量CT(ssDECT)平扫对肾上腺乏脂性腺瘤与转移瘤的鉴别价值。方法回顾性分析2011年8月至2014年10月间进行ssDECT平扫的肾上腺乏脂性腺瘤和转移瘤患者63例(共73个病灶),其中乏脂性腺瘤20个(CT值〉10 HU,均经病理证实),转移瘤53个(至少经5~6个月随诊证实)。在ADW4.5工作站上,分别测量平扫各病灶的常规混合能量CT值、不同单能量(40~140 keV)CT值、脂-水浓度和有效原子序数,并进行诊断效能的受试者工作特征曲线(ROC曲线)分析。分别测量并计算各病灶的能谱曲线斜率(K),并将能谱曲线分为上升型(K〉0.1)、平直型(-0.1≤K≤0.1)和...

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Published in中华肿瘤杂志 Vol. 38; no. 11; pp. 826 - 832
Main Author 鞠烨 刘爱连 汪禾青 刘义军 刘静红 陈安良 陈丽华 李烨 韩铮
Format Journal Article
LanguageChinese
Published 116011,大连医科大学附属第一医院放射科 2016
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ISSN0253-3766
DOI10.3760/cma.j.issn.0253-3766.2016.11.005

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Abstract 目的探讨单源双能量CT(ssDECT)平扫对肾上腺乏脂性腺瘤与转移瘤的鉴别价值。方法回顾性分析2011年8月至2014年10月间进行ssDECT平扫的肾上腺乏脂性腺瘤和转移瘤患者63例(共73个病灶),其中乏脂性腺瘤20个(CT值〉10 HU,均经病理证实),转移瘤53个(至少经5~6个月随诊证实)。在ADW4.5工作站上,分别测量平扫各病灶的常规混合能量CT值、不同单能量(40~140 keV)CT值、脂-水浓度和有效原子序数,并进行诊断效能的受试者工作特征曲线(ROC曲线)分析。分别测量并计算各病灶的能谱曲线斜率(K),并将能谱曲线分为上升型(K〉0.1)、平直型(-0.1≤K≤0.1)和下降型(K〈 -0.1),比较肾上腺乏脂性腺瘤和转移瘤的曲线类型。结果转移瘤组和乏脂性腺瘤组的常规混合能量CT值分别为(35.12±5.29 )HU和(32.48±6.94) HU,差异无统计学意义(P〉0.05)。在40~80 keV水平下,转移瘤组的单能量CT值在(53.00±15.12) HU~(33.38±5.67) HU间,乏脂性腺瘤组的单能量CT值在(26.90±26.94) HU~(28.77±10.66) HU间,差异有统计学意义(均P〈0.05)。在90~140 keV水平下,转移瘤组和乏脂性腺瘤组的单能量CT值差异无统计学意义(P〉0.05)。转移瘤组和乏脂性腺瘤组的中位脂-水浓度分别为-164.61 μg/cm3和114.32 μg/cm3,差异有统计学意义(P〈0.05)。转移瘤组和乏脂性腺瘤组的有效原子序数分别为7.76±0.15和7.50±0.25,差异有统计学意义(P〈0.05)。当脂-水浓度阈值为-143.89 μg/cm3,诊断转移瘤的敏感度为70.0%,特异度为66.0%,正确率为76.7%。当有效原子序数阈值为7.63,诊断转移瘤的敏感度为83.0%,特异度为65.0%,正确率为80.4%。在40~80 keV下,能量越低,诊断转移瘤的正确率越高,其中40 keV的诊断效能最高。20例乏脂性腺瘤组患者中,能谱曲线类型为上升型9例(45.0%),平直型4例(20.0%),下降型7例(35.0%)。53例转移瘤组患者中,能谱曲线类型为上升型2例(3.8%),平直型9例(17.0%),下降型42例(79.2%)。两组患者曲线类型构成比的差异有统计学意义(P〈0.05)。 结论ssDECT平扫为
AbstractList 目的:探讨单源双能量CT( ssDECT)平扫对肾上腺乏脂性腺瘤与转移瘤的鉴别价值。方法回顾性分析2011年8月至2014年10月间进行ssDECT平扫的肾上腺乏脂性腺瘤和转移瘤患者63例(共73个病灶),其中乏脂性腺瘤20个(CT 值>10 HU,均经病理证实),转移瘤53个(至少经5~6个月随诊证实)。在ADW4.5工作站上,分别测量平扫各病灶的常规混合能量CT值、不同单能量(40~140 keV)CT值、脂-水浓度和有效原子序数,并进行诊断效能的受试者工作特征曲线(ROC曲线)分析。分别测量并计算各病灶的能谱曲线斜率(K),并将能谱曲线分为上升型(K>0.1)、平直型(-0.1≤K≤0.1)和下降型(K<-0.1),比较肾上腺乏脂性腺瘤和转移瘤的曲线类型。结果转移瘤组和乏脂性腺瘤组的常规混合能量CT值分别为(35.12±5.29)HU和(32.48±6.94) HU,差异无统计学意义(P>0.05)。在40~80 keV水平下,转移瘤组的单能量CT值在(53.00±15.12) HU~(33.38±5.67)HU 间,乏脂性腺瘤组的单能量CT值在(26.90±26.94) HU~(28.77±10.66) HU间,差异有统计学意义(均P<0.05)。在90~140 keV水平下,转移瘤组和乏脂性腺瘤组的单能量CT值差异无统计学意义( P>0.05)。转移瘤组和乏脂性腺瘤组的中位脂-水浓度分别为-164.61μg/cm3和114.32μg/cm3,差异有统计学意义(P<0.05)。转移瘤组和乏脂性腺瘤组的有效原子序数分别为7.76±0.15和7.50±0.25,差异有统计学意义( P<0.05)。当脂-水浓度阈值为-143.89μgc/m 3,诊断转移瘤的敏感度为70.0%,特异度为66.0%,正确率为76.7%。当有效原子序数阈值为7.63,诊断转移瘤的敏感度为83.0%,特异度为65.0%,正确率为80.4%。在40~80 keV下,能量越低,诊断转移瘤的正确率越高,其中40 keV 的诊断效能最高。20例乏脂性腺瘤组患者中,能谱曲线类型为上升型9例(45.0%),平直型4例(20.0%),下降型7例(35.0%)。53例转移瘤组患者中,能谱曲线类型为上升型2例(3.8%),平直型9例(17.0%),下降型42例(79.2%)。两组患者曲线类型构成比的差异有统计学意义( P<0.05)。结论 ssDECT
目的探讨单源双能量CT(ssDECT)平扫对肾上腺乏脂性腺瘤与转移瘤的鉴别价值。方法回顾性分析2011年8月至2014年10月间进行ssDECT平扫的肾上腺乏脂性腺瘤和转移瘤患者63例(共73个病灶),其中乏脂性腺瘤20个(CT值〉10 HU,均经病理证实),转移瘤53个(至少经5~6个月随诊证实)。在ADW4.5工作站上,分别测量平扫各病灶的常规混合能量CT值、不同单能量(40~140 keV)CT值、脂-水浓度和有效原子序数,并进行诊断效能的受试者工作特征曲线(ROC曲线)分析。分别测量并计算各病灶的能谱曲线斜率(K),并将能谱曲线分为上升型(K〉0.1)、平直型(-0.1≤K≤0.1)和下降型(K〈 -0.1),比较肾上腺乏脂性腺瘤和转移瘤的曲线类型。结果转移瘤组和乏脂性腺瘤组的常规混合能量CT值分别为(35.12±5.29 )HU和(32.48±6.94) HU,差异无统计学意义(P〉0.05)。在40~80 keV水平下,转移瘤组的单能量CT值在(53.00±15.12) HU~(33.38±5.67) HU间,乏脂性腺瘤组的单能量CT值在(26.90±26.94) HU~(28.77±10.66) HU间,差异有统计学意义(均P〈0.05)。在90~140 keV水平下,转移瘤组和乏脂性腺瘤组的单能量CT值差异无统计学意义(P〉0.05)。转移瘤组和乏脂性腺瘤组的中位脂-水浓度分别为-164.61 μg/cm3和114.32 μg/cm3,差异有统计学意义(P〈0.05)。转移瘤组和乏脂性腺瘤组的有效原子序数分别为7.76±0.15和7.50±0.25,差异有统计学意义(P〈0.05)。当脂-水浓度阈值为-143.89 μg/cm3,诊断转移瘤的敏感度为70.0%,特异度为66.0%,正确率为76.7%。当有效原子序数阈值为7.63,诊断转移瘤的敏感度为83.0%,特异度为65.0%,正确率为80.4%。在40~80 keV下,能量越低,诊断转移瘤的正确率越高,其中40 keV的诊断效能最高。20例乏脂性腺瘤组患者中,能谱曲线类型为上升型9例(45.0%),平直型4例(20.0%),下降型7例(35.0%)。53例转移瘤组患者中,能谱曲线类型为上升型2例(3.8%),平直型9例(17.0%),下降型42例(79.2%)。两组患者曲线类型构成比的差异有统计学意义(P〈0.05)。 结论ssDECT平扫为
Abstract_FL Objective To evaluate the value of single-source dual-energy CT ( ssDECT ) in differentiating lipid-poor adenomas from metastases in adrenal glands .Methods From August 2011 to Oct 2014,63 patients with 73 adrenal nodules ( 53 metastases proven by 5-6 months follow-up, and 20 histopathologically proven adenomas , CT value >10 HU) underwent ssDECT scanning .The CT values of conventional polychromatic CT and virtual monochromatic images ( 40-140 keV) , fat-water density images and effective atomic number (eff-Z) were reconstructed on an ADW4.5 workstation and ROC curves were then constructed to evaluate the effectiveness of each parameter .The slope of spectral curve was measured and divided into 3 types:increment curve ( K>0.1) , straight curve (-0.1≤K≤0.1) and decrement curve ( K<-0.1) according to the slope ( the value of K ) of spectral curve , and the curve patterns in the two groups were compared statistically .Results There was no statistical difference between the mean CT values of metastases (35.12±5.29)HU and lipid-poor adenomas (32.48±6.94)HU by conventional polychromatic CT (P>0.05).The range of single-energy CT values of metastases [from (53.00±15.12) HU to (33.38± 5.67) HU] was significantly higher than that of lipid-poor adenomas [from (26.90±26.94) HU to (28.77± 10.66) HU] at energy levels ranging from 40 to 80 keV ( P<0.05).There was no significant difference between the single-energy CT value of metastases and lipid-poor adenomas at energy levels ranging from 90 to 140 keV (P>0.05).The median fat-water concentration of metastases was -164.61 μg/cm3, significantly lower than that of lipid-poor adenomas (114.32 μg/cm3, P<0.05).The eff-Z of metastases (7.76±0.15) was also significantly higher than that of lipid-poor adenomas (7.50±0.25, P<0.05).When the threshold of fat-water concentration was -143.89 μg/cm3 , the sensitivity, specificity and accuracy rate of metastasis diagnosis was 70.0%, 66.0%, and 76.7%, respectively.When the threshold of eff-Z was 7.63, the sensitivity , specificity and accuracy rate of metastasis diagnosis was 83.0%, 65.0%, and 80.4%, respectively .The lower the energy , the higher the diagnostic accuracy at energy levels ranging from 40 to 80 keV, and that of 40 keV was the highest .The spectral curves of metastases included 2 ( 3.8%) ascending curves, 9 (17.0%) straight curves and 42 (792.%) descending curves, while in the 20 lipid-poor adenomas, there were 9 ( 45.0%) ascending curves , 4 ( 20.0%) straight curves and 7 ( 35.0%) descending curves , showing significant differences between the two groups ( P<0.05) .Conclu sions Single-source dual-energy CT provides an effective multi-parameter approach for differentiating lipid-poor adrenal adenomas from metastases .
Author 鞠烨 刘爱连 汪禾青 刘义军 刘静红 陈安良 陈丽华 李烨 韩铮
AuthorAffiliation 大连医科大学附属第一医院放射科,116011
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Author_FL Chen Lihua
Li Ye
Liu Yijun
Chen Anliang
Ju Ye
Han Zheng
Wang Heqing
Liu Ailian
Liu Jinghong
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DocumentTitleAlternate Value of single-source dual-energy CT (ssDECT) in differentiating lipid-poor adrenal adenomas from metastatic lesions
DocumentTitle_FL Va lue fo single-source dual-energyC T (ssDECT) in differen tiatingl ipid-po or adr enal aden omas from metsa tatci l esions
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Issue 11
Keywords 双能量CT
诊断
Tomography,X-ray computer
肾上腺肿瘤
体层摄影术, X线计算机
Adrenal neoplasms
Dual-energy CT
肾上腺转移
Diagnosis
Adrenal metastases
Language Chinese
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Notes 11-2152/R
Adrenal neoplasms; Diagnosis; Adrenal metastases; Tomography, X-ray computer; Dual-energy CT
Ju Ye, Liu Ailian, Wang Heqing, Liu Yijun, Liu Jinghong, Chen Anliang, Chen Lihua, Li Ye, Han Zheng( Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China)
ObjectiveTo evaluate the value of single-source dual-energy CT (ssDECT) in differentiating lipid-poor adenomas from metastases in adrenal glands.MethodsFrom August 2011 to Oct 2014, 63 patients with 73 adrenal nodules (53 metastases proven by 5-6 months follow-up, and 20 histopathologically proven adenomas, CT value 〉 10 HU) underwent ssDECT scanning. The CT values of conventional polychromatic CT and virtual monochromatic images (40-140 keV) , fat-water density images and effective atomic number (eff-Z) were reconstructed on an ADW4.5 workstation and ROC curves were then constructed to evaluate the effectiveness of each parameter. The slope of spectral curve was measured and divided into 3 types: increment
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PublicationTitle 中华肿瘤杂志
PublicationTitleAlternate Chinese Journal of Oncology
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Snippet 目的探讨单源双能量CT(ssDECT)平扫对肾上腺乏脂性腺瘤与转移瘤的鉴别价值。方法回顾性分析2011年8月至2014年10月间进行ssDECT平扫的肾上腺乏脂性腺瘤和转移瘤患者63例(共73个病灶),其中乏脂性腺瘤20个(CT值〉10...
目的:探讨单源双能量CT( ssDECT)平扫对肾上腺乏脂性腺瘤与转移瘤的鉴别价值。方法回顾性分析2011年8月至2014年10月间进行ssDECT平扫的肾上腺乏脂性腺瘤和转移瘤患者63例(共73个病灶),其中乏脂性腺瘤20个(CT 值>10...
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StartPage 826
SubjectTerms X线计算机
体层摄影术
双能量CT
肾上腺肿瘤
肾上腺转移
诊断
Title 单源双能量CT平扫对肾上腺乏脂性腺瘤与转移瘤的鉴别价值
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