Viral Population Heterogeneity and Fluctuating Mutational Pattern during a Persistent SARS-CoV-2 Infection in an Immunocompromised Patient

• Published in: Viruses Vol. 15; no. 2; p. 291
• Main Authors: Brandolini, Martina, Zannoli, Silvia, Gatti, Giulia, Arfilli, Valentina, Cricca, Monica, Dirani, Giorgio, Denicolò, Agnese, Semprini, Simona, Grumiro, Laura, Imola, Manuela, Larne, Damiano, Marino, Maria Michela, Manera, Martina, Mancini, Andrea, Taddei, Francesca, Zagarrigo, Manuel, Biagetti, Carlo, Sambri, Vittorio
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.01.2023; MDPI
• Subjects: Case Report; chronic diseases; COVID-19; Cytomegalovirus; Evaluation; Evolution; genetic similarity; Hematology; Humans; Immunocompromised Host; Immunocompromised hosts; immunocompromised patients; Infections; intra-host evolution; Laboratories; Lymphoma; Monoclonal antibodies; Mutation; NGS whole-genome sequencing; patients; Persistent infection; Polymerase chain reaction; SARS-CoV-2; SARS-CoV-2 - genetics; Sequence analysis; Serology; Severe acute respiratory syndrome coronavirus 2; viruses; Whole genome sequencing; Italy; United States > US; Taiwan; COVID-19; NGS whole-genome sequencing; immunocompromised patients; intra-host evolution; SARS-CoV-2

Literature offers plenty of cases of immunocompromised patients, who develop chronic and severe SARS-CoV-2 infections. The aim of this study is to provide further insight into SARS-CoV-2 evolutionary dynamic taking into exam a subject suffering from follicular lymphoma, who developed a persistent in...