Nanotechnology as a Promising Approach to Combat Multidrug Resistant Bacteria: A Comprehensive Review and Future Perspectives

The wide spread of antibiotic resistance has been alarming in recent years and poses a serious global hazard to public health as it leads to millions of deaths all over the world. The wide spread of resistance and sharing resistance genes between different types of bacteria led to emergence of multi...

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Published inBiomedicines Vol. 11; no. 2; p. 413
Main Authors Hetta, Helal F., Ramadan, Yasmin N., Al-Harbi, Alhanouf I., A. Ahmed, Esraa, Battah, Basem, Abd Ellah, Noura H., Zanetti, Stefania, Donadu, Matthew Gavino
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 31.01.2023
MDPI
Subjects
Antibacterial activity
Antibiotic resistance
Antibiotics
Antimicrobial agents
Bacteria
biofilm
Biofilms
Drug delivery systems
Drug development
Drug resistance
Enzymes
Fourier transforms
Health aspects
Infections
MDR bacteria
Metabolism
Microbial colonies
Microorganisms
Microscopy
Multidrug resistance
Multidrug resistant organisms
nanoantibiotics
Nanoparticles
Nanotechnology
Physical characteristics
Public health
Quantum dots
Review
Reviews
Severe acute respiratory syndrome coronavirus 2
Viral infections
XDR bacteria
Egypt
nanotechnology
XDR bacteria
nanoantibiotics
MDR bacteria
biofilm
Online AccessGet full text
ISSN2227-9059
2227-9059
DOI10.3390/biomedicines11020413

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Abstract The wide spread of antibiotic resistance has been alarming in recent years and poses a serious global hazard to public health as it leads to millions of deaths all over the world. The wide spread of resistance and sharing resistance genes between different types of bacteria led to emergence of multidrug resistant (MDR) microorganisms. This problem is exacerbated when microorganisms create biofilms, which can boost bacterial resistance by up to 1000-fold and increase the emergence of MDR infections. The absence of novel and potent antimicrobial compounds is linked to the rise of multidrug resistance. This has sparked international efforts to develop new and improved antimicrobial agents as well as innovative and efficient techniques for antibiotic administration and targeting. There is an evolution in nanotechnology in recent years in treatment and prevention of the biofilm formation and MDR infection. The development of nanomaterial-based therapeutics, which could overcome current pathways linked to acquired drug resistance, is a hopeful strategy for treating difficult-to-treat bacterial infections. Additionally, nanoparticles’ distinct size and physical characteristics enable them to target biofilms and treat resistant pathogens. This review highlights the current advances in nanotechnology to combat MDR and biofilm infection. In addition, it provides insight on development and mechanisms of antibiotic resistance, spread of MDR and XDR infection, and development of nanoparticles and mechanisms of their antibacterial activity. Moreover, this review considers the difference between free antibiotics and nanoantibiotics, and the synergistic effect of nanoantibiotics to combat planktonic bacteria, intracellular bacteria and biofilm. Finally, we will discuss the strength and limitations of the application of nanotechnology against bacterial infection and future perspectives.
AbstractList The wide spread of antibiotic resistance has been alarming in recent years and poses a serious global hazard to public health as it leads to millions of deaths all over the world. The wide spread of resistance and sharing resistance genes between different types of bacteria led to emergence of multidrug resistant (MDR) microorganisms. This problem is exacerbated when microorganisms create biofilms, which can boost bacterial resistance by up to 1000-fold and increase the emergence of MDR infections. The absence of novel and potent antimicrobial compounds is linked to the rise of multidrug resistance. This has sparked international efforts to develop new and improved antimicrobial agents as well as innovative and efficient techniques for antibiotic administration and targeting. There is an evolution in nanotechnology in recent years in treatment and prevention of the biofilm formation and MDR infection. The development of nanomaterial-based therapeutics, which could overcome current pathways linked to acquired drug resistance, is a hopeful strategy for treating difficult-to-treat bacterial infections. Additionally, nanoparticles’ distinct size and physical characteristics enable them to target biofilms and treat resistant pathogens. This review highlights the current advances in nanotechnology to combat MDR and biofilm infection. In addition, it provides insight on development and mechanisms of antibiotic resistance, spread of MDR and XDR infection, and development of nanoparticles and mechanisms of their antibacterial activity. Moreover, this review considers the difference between free antibiotics and nanoantibiotics, and the synergistic effect of nanoantibiotics to combat planktonic bacteria, intracellular bacteria and biofilm. Finally, we will discuss the strength and limitations of the application of nanotechnology against bacterial infection and future perspectives.
The wide spread of antibiotic resistance has been alarming in recent years and poses a serious global hazard to public health as it leads to millions of deaths all over the world. The wide spread of resistance and sharing resistance genes between different types of bacteria led to emergence of multidrug resistant (MDR) microorganisms. This problem is exacerbated when microorganisms create biofilms, which can boost bacterial resistance by up to 1000-fold and increase the emergence of MDR infections. The absence of novel and potent antimicrobial compounds is linked to the rise of multidrug resistance. This has sparked international efforts to develop new and improved antimicrobial agents as well as innovative and efficient techniques for antibiotic administration and targeting. There is an evolution in nanotechnology in recent years in treatment and prevention of the biofilm formation and MDR infection. The development of nanomaterial-based therapeutics, which could overcome current pathways linked to acquired drug resistance, is a hopeful strategy for treating difficult-to-treat bacterial infections. Additionally, nanoparticles' distinct size and physical characteristics enable them to target biofilms and treat resistant pathogens. This review highlights the current advances in nanotechnology to combat MDR and biofilm infection. In addition, it provides insight on development and mechanisms of antibiotic resistance, spread of MDR and XDR infection, and development of nanoparticles and mechanisms of their antibacterial activity. Moreover, this review considers the difference between free antibiotics and nanoantibiotics, and the synergistic effect of nanoantibiotics to combat planktonic bacteria, intracellular bacteria and biofilm. Finally, we will discuss the strength and limitations of the application of nanotechnology against bacterial infection and future perspectives.The wide spread of antibiotic resistance has been alarming in recent years and poses a serious global hazard to public health as it leads to millions of deaths all over the world. The wide spread of resistance and sharing resistance genes between different types of bacteria led to emergence of multidrug resistant (MDR) microorganisms. This problem is exacerbated when microorganisms create biofilms, which can boost bacterial resistance by up to 1000-fold and increase the emergence of MDR infections. The absence of novel and potent antimicrobial compounds is linked to the rise of multidrug resistance. This has sparked international efforts to develop new and improved antimicrobial agents as well as innovative and efficient techniques for antibiotic administration and targeting. There is an evolution in nanotechnology in recent years in treatment and prevention of the biofilm formation and MDR infection. The development of nanomaterial-based therapeutics, which could overcome current pathways linked to acquired drug resistance, is a hopeful strategy for treating difficult-to-treat bacterial infections. Additionally, nanoparticles' distinct size and physical characteristics enable them to target biofilms and treat resistant pathogens. This review highlights the current advances in nanotechnology to combat MDR and biofilm infection. In addition, it provides insight on development and mechanisms of antibiotic resistance, spread of MDR and XDR infection, and development of nanoparticles and mechanisms of their antibacterial activity. Moreover, this review considers the difference between free antibiotics and nanoantibiotics, and the synergistic effect of nanoantibiotics to combat planktonic bacteria, intracellular bacteria and biofilm. Finally, we will discuss the strength and limitations of the application of nanotechnology against bacterial infection and future perspectives.
Audience Academic
Author A. Ahmed, Esraa
Zanetti, Stefania
Hetta, Helal F.
Al-Harbi, Alhanouf I.
Donadu, Matthew Gavino
Ramadan, Yasmin N.
Battah, Basem
Abd Ellah, Noura H.
AuthorAffiliation 1 Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
5 Department of Biochemistry and Microbiology, Faculty of Pharmacy, Syrian Private University (SPU), Daraa International Highway, 36822 Damascus, Syria
4 Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
3 Department of Medical Laboratory, College of Applied Medical Sciences, Taibah University, Yanbu 46411, Saudi Arabia
9 Hospital Pharmacy, Azienda Ospedaliero Universitaria di Sassari, 07100 Sassari, Italy
6 Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt
7 Department of Pharmaceutics, Faculty of Pharmacy, Badr University in Assiut, Naser City, Assiut 2014101, Egypt
2 Department of Microbiology and Immunology, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt
8 Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
AuthorAffiliation_xml – name: 7 Department of Pharmaceutics, Faculty of Pharmacy, Badr University in Assiut, Naser City, Assiut 2014101, Egypt
– name: 5 Department of Biochemistry and Microbiology, Faculty of Pharmacy, Syrian Private University (SPU), Daraa International Highway, 36822 Damascus, Syria
– name: 2 Department of Microbiology and Immunology, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt
– name: 6 Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt
– name: 1 Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
– name: 4 Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
– name: 9 Hospital Pharmacy, Azienda Ospedaliero Universitaria di Sassari, 07100 Sassari, Italy
– name: 3 Department of Medical Laboratory, College of Applied Medical Sciences, Taibah University, Yanbu 46411, Saudi Arabia
– name: 8 Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
Author_xml – sequence: 1
  givenname: Helal F.
  orcidid: 0000-0001-8541-7304
  surname: Hetta
  fullname: Hetta, Helal F.
– sequence: 2
  givenname: Yasmin N.
  surname: Ramadan
  fullname: Ramadan, Yasmin N.
– sequence: 3
  givenname: Alhanouf I.
  orcidid: 0000-0003-0889-2886
  surname: Al-Harbi
  fullname: Al-Harbi, Alhanouf I.
– sequence: 4
  givenname: Esraa
  surname: A. Ahmed
  fullname: A. Ahmed, Esraa
– sequence: 5
  givenname: Basem
  surname: Battah
  fullname: Battah, Basem
– sequence: 6
  givenname: Noura H.
  surname: Abd Ellah
  fullname: Abd Ellah, Noura H.
– sequence: 7
  givenname: Stefania
  surname: Zanetti
  fullname: Zanetti, Stefania
– sequence: 8
  givenname: Matthew Gavino
  orcidid: 0000-0001-7681-6194
  surname: Donadu
  fullname: Donadu, Matthew Gavino
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36830949$$D View this record in MEDLINE/PubMed
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Snippet The wide spread of antibiotic resistance has been alarming in recent years and poses a serious global hazard to public health as it leads to millions of deaths...
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StartPage 413
SubjectTerms Antibacterial activity
Antibiotic resistance
Antibiotics
Antimicrobial agents
Bacteria
biofilm
Biofilms
Drug delivery systems
Drug development
Drug resistance
Enzymes
Fourier transforms
Health aspects
Infections
MDR bacteria
Metabolism
Microbial colonies
Microorganisms
Microscopy
Multidrug resistance
Multidrug resistant organisms
nanoantibiotics
Nanoparticles
Nanotechnology
Physical characteristics
Public health
Quantum dots
Review
Reviews
Severe acute respiratory syndrome coronavirus 2
Viral infections
XDR bacteria
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Title Nanotechnology as a Promising Approach to Combat Multidrug Resistant Bacteria: A Comprehensive Review and Future Perspectives
URI https://www.ncbi.nlm.nih.gov/pubmed/36830949
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Volume 11
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