Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformation

• Published in: Oncogene Vol. 26; no. 20; pp. 2950 - 2954
• Main Authors: CHIKAMORI, M, FUJIMOTO, J, TOKAI-NISHIZUMI, N, YAMAMOTO, T
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 03.05.2007; Nature Publishing Group
• Subjects: 1-Phosphatidylinositol 3-kinase; Adaptor proteins; Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Anaplastic large-cell lymphoma; Animals; Binding Sites; Binding sites (Biochemistry); Biological and medical sciences; Cancer; Cell physiology; Cell transformation; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Cell Transformation, Neoplastic - metabolism; Cells, Cultured; Cellular signal transduction; Chromosome translocations; Fundamental and applied biological sciences. Psychology; Genetic aspects; Genetic transformation; Genetics; Health aspects; Hematologic and hematopoietic diseases; Humans; Immunoprecipitation; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphocytes T; Lymphoma; Medical sciences; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Molecular and cellular biology; Mutants; Neurotrophic factors; NIH 3T3 Cells; Oncology; Oncoproteins; Phospholipase C; Phosphorylation; Physiological aspects; Protein Interaction Mapping; Protein-tyrosine kinase; Protein-Tyrosine Kinases - genetics; Protein-Tyrosine Kinases - metabolism; Proteins; Transfection; Tumorigenesis; Two-Hybrid System Techniques; United States; Tyrosine; Phosphorylation; NPM-ALK; Malignant hemopathy; Identification; Large cell lymphoma; Binding site; Malignant tumor; Non Hodgkin lymphoma; Cell transformation; Carcinogenesis; anaplastic large-cell lymphoma; Lymphoproliferative syndrome; C-Onc gene; SNT; tyrosine phosphorylation; Onc gene; oncoprotein

The t(2;5) chromosomal translocation occurs in anaplastic large-cell lymphoma arising from activated T lymphocytes. This genomic rearrangement generates the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) oncoprotein that is a chimeric protein consisting of parts of the nuclear protein NPM and...