Neutrophils, eosinophils, and intraepithelial lymphocytes in the squamous esophagus in subjects with and without gastroesophageal reflux symptoms

• Published in: Human pathology Vol. 115; pp. 112 - 122
• Main Authors: Zand Irani, Mudar, Talley, Nicholas J., Ronkainen, Jukka, Aro, Pertti, Andreasson, Anna, Agreus, Lars, Vieth, Michael, Jones, Mike P., Walker, Marjorie M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2021; Elsevier Limited
• Subjects: Acids; Adult; Age; Aged; Biopsy; Dysphagia; Endoscopy; Eosinophils; Eosinophils - cytology; Eosinophils - pathology; Esophageal Mucosa - cytology; Esophageal Mucosa - pathology; Esophagitis; Esophagus; Female; Gastroesophageal reflux; Gastroesophageal Reflux - pathology; Gastroesophageal reflux disease; Gender; Histology; Histopathology; Humans; Hyperplasia; Intra-epithelial lympho-cytes; Intra-epithelial lymphocytes; Intraepithelial Lymphocytes - cytology; Intraepithelial Lymphocytes - pathology; Lymphocytes; Male; Middle Aged; Neutrophils; Neutrophils - cytology; Neutrophils - pathology; Reference Values; Statistical analysis; IEL; GERD; FH; Intra-epithelial lymphocytes; Gastroesophageal reflux disease; Neutrophils; Esophagitis; LE; NERD; GERS; Eosinophils; HPF

Whilst intraepithelial lymphocytes (IELs) are considered normal within the distal esophageal mucosa, they have an increasingly recognised role in the pathogenesis of reflux esophagitis, and IEL quantification establishes the diagnosis of lymphocytic esophagitis. Knowledge regarding the upper limit o...